Clinical, Functional, and Radiographic Differences Among Juvenile-onset, Adult-onset, and Late-onset Ankylosing Spondylitis

Abstract

Sex and HLA-B27 are significantly associated with age at onset of AS. Both JoAS and LoAS have their distinctive symptoms/signs at onset and different disease outcomes.

Rheumatic disease in elderly population, how different from the conventional presentations?

“…From Asia, the only published data from Taiwan showed an incidence of 3.5% of LOSpA in a cohort of 546 SpA patients. 32 PsA is more common in the elderly than believed. In 2009, Wilson et al published time trends in a group of 147 incident PsA patients over 30 years (90 men and 57 women) meeting the CASPAR criteria.…”

Juvenile Versus Adult-Onset Ankylosing Spondylitis: Are We Comparing Apples and Oranges?

“…It is important therefore to evaluate the differences between juvenile and adult-onset AS in different ethnic groups. In this issue of The Journal, Chen, et al present the findings of a study assessing this in an ethnic Chinese population 17 . The estimated prevalence of AS in China is 0.24% 18 , which, based on an estimated Chinese population of 1.3 billion, makes Han Chinese the most common ethnicity in terms of total numbers of patients with AS.…”

Endothelial Dysfunction and Cardiovascular Risk in Patients With Ankylosing Spondylitis

“…and detection of HLA B-27. Clinical activity of the disease was determined using the disease activity index BASDAI, BASFI functional index and BASMI metrology index, ASQoL quality of life [2,4]. Endothelium vasodilatation was evaluated in response to reactive hyperaemia in 57 patients by the method, which was first described by D. Celermajer [9], using Acuson 128 XP/10 ultrasonic complex equipped with a 7 MHz linear transducer.…”