Clinical-morphological and electron-microscopic studies of the growth plate in solitary bone cysts

Abstract

The occasional humeral growth retardation or premature closure of the growth plate medially, documented among more than 120 solitary bone cysts reviewed, was reason to undertake a thorough study of the growth plate in the area of the cyst. The findings in the hyaline zone disclose a considerable number of vessels and slits of the cartilage that are broadened toward the proliferative and hypertrophic zones. In some places they communicate with the vessels or are lined with endothelium. Ultrastructurally, changes of a destructive nature are disclosed, involving the growth plate zone and corresponding to the most active metabolic processes. In the altered chondrocytes substantial increases in glycogen granules and lipid droplets are observed, as well as reduction of the cellular organelles. In rather severely affected cells changes in the nuclei, lysosomal structures, and myelin-like lamellar bodies are established. The disappearance of cellular organelles and the fragmentation of cytoplasm are interpreted as a final phase of the above-listed changes. In conclusion, the cyst is considered a probable primary cause of the changes described.

Treatment of unicameral bone cyst: Systematic review and meta analysis

“…Sixty-two articles were eligible for the quantitative systematic review [3, 6, 8–67]. The rest of the articles were excluded, including: 97 articles that were not in English or French [68–164], one randomized clinical trial [165], one prospective study [166], seven case series [167–173], 174 case reports [2, 174–346], 10 basic science articles [5, 347–355], 26 articles that did not discuss UBC treatment [1, 356–380], 17 articles that did not represent clear data on healing [381–397], 18 review articles [4, 398–414], one article that was a reprint [415], three commentary articles [416–418], 36 articles with a sample size smaller than 15 [419–454], and ten articles with possibility of shared cohort [455–464] (Fig. 1).…”

“…Sixty-two articles were eligible for the quantitative systematic review [3,6,. The rest of the articles were excluded, including: 97 articles that were not in English or French [68-164], one randomized clinical trial [165], one prospective study [166], seven case series [167-173], 174 case reports [2, 174-346], 10 basic science articles [5, [347][348][349][350][351][352][353][354][355], 26 articles that did not discuss UBC treatment [1, , 17 articles that did not represent clear data on healing [381][382][383][384][385][386][387][388][389][390][391][392][393][394][395][396][397], 18 review articles [4, [398][399][400][401][402][403][404][405][406][407][408][409][410][411][412][413][414], one article that ...…”

A brief review on hydroxyapatite production and use in biomedicine

“…The knowledge about the structure and chemical composition of bones was gradually acquired over time. It dates back the ancient civilizations that used bones as tools and extended until present time with the understanding of the basic unit that constitutes them [1,2]. Bone is a hierarchically ordered structure having a uniform arrangement of calcium phosphate (CaP) nanocrystals (with calcium deficiency) in collagen fibrils, which may be settled in a lamellar or layer by layer fashion, depending on the nature of the bone [3].…”

Synthesis, Characterization, Functionalization and Bio-Applications of Hydroxyapatite Nanomaterials: An Overview

“…Microscopic methods noticeably enhanced bone research, particularly with collagen fibrils, the building blocks of bone. 2,3 The crystals of bones are the smallest crystals manufactured naturally with 2-4 nm width and a few nm long. 4 The composition of bone can be ordered in a pyramid fashion, like muscles, with hydroxyapatite (HA) crystals at the pyramid base.…”