Clinical oral and salivary parameters of children with juvenile idiopathic arthritis

Compromised salivary parameters of children with juvenile idiopathic arthritis

“…28,34 Sialic acid-rich glycoproteins as mucin promote lubrication of the oral pH. 13 It was demonstrated here that JIA patients also shows a reduction in the concentration of salivary calcium and phosphate. Besides the tendency to demineralization because of salivary buffering conditions, these patients may have a favorable osmotic gradient for loss of minerals from the tooth structure.…”

“…12 One study reported increased dental biofilm in patients with JIA, measured by the oral hygiene index. 13 Saliva plays an important role in maintaining oral health and has been used for diagnosis and monitoring of systemic diseases, including autoimmune diseases. [14][15][16] The organic and inorganic composition of whole saliva performs many functions such as dental remineralization, antimicrobial action, mucosa protection through lubrication and regeneration, buffering capacity, food digestion.…”

“…17 Previous studies described major salivary changes in JIA patients, such as changed profile of salivary buffer capacity, reduced inorganic components (calcium, phosphorus, potassium, sodium, chloride), immune and antimicrobial factors (immunoglobulin A and lysozyme). 13,18,19 Considering that JIA patients present high risk for the development of oral diseases, it is important to evaluate the salivary defense components in the oral cavity of these individuals. Salivary changes were reported previously in the saliva of JIA patients.…”

“…Salivary changes were reported previously in the saliva of JIA patients. 13 Thus, the purpose of this study was to evaluate the digestive (α-amylase activity), antimicrobial (lactoperoxidase activity) and lubricant (sialic acid concentration) parameters in stimulated whole saliva of JIA patients. Some components that participate in the dental remineralization process such as calcium and phosphate concentration were also evaluated.…”

“…The social demographics characteristics of the participants of this study were previously reported and confirmed the homogeneity of the groups. 13 Additionally, children with JIA presented 50.18 ± 39.8 months of disease length. …”