Clinical outcome comparison of polymethylmethacrylate bone cement with and without mineralized collagen modification for osteoporotic vertebral compression fractures

Wang, Xi; Kou, Jian-Ming; Yang, Yue; Weng, Xisheng; Qiu, Zhiye; Zhang, Xifeng

doi:10.1097/md.0000000000012204

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…Within the biomimetic MC, HA is a poorly crystallized nanoparticle, which is arranged periodically and orderly among the collagen molecules. The biomimetic MC possesses the same chemical composition and microstructure as the natural bone matrix of human body, which can provide a good microenvironment for the activity of bone cells and help guide the regeneration of bone tissue [ 11–14 ]. In this study, although the MSTS score of the MC group was initially better than that of the autogenous bone group, the Lane–Sandhu X-ray score of the MC group was significantly lower in imaging with statistically significant difference at 1 month after the operation.…”

Section: Discussionmentioning

confidence: 99%

“…Relevant animal experiments have shown that the biomimetic MC can effectively guide bone tissue regeneration and repair bone defect. After using in traumatic bone defect and bone fusion after spinal surgery, it has a good performance in guiding bone regeneration [ 11–14 ]. However, for the bone defect induced by curettage of benign bone tumors with high risk of recurrence and pathological fracture, clinical observation of the treatment of such bone defect by using biomimetic MC was not reported.…”

Section: Introductionmentioning

confidence: 99%

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Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Gao

Qiu

Hou

et al. 2020

Regenerative Biomaterials

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Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this work, a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC, in comparison to another group treated with the same surgical method and autogenous bone. Lane–Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation, but the two groups had no statistical difference at 6 and 12 months. The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation, and the two groups had no statistical difference at 12 month. Therefore, the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups. Moreover, the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Gao

Qiu

Hou

et al. 2020

Regenerative Biomaterials

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“…Certainly, bone cement is the part of operation as well. Mineralized collagen polymethyl methacrylate (MC-PMMA) bone cement has better bioabsorbability and improved biocompatibility [46][47][48]. At present, MC-PMMA have been used and reported in three researches, but the results were mixed.…”

Section: Reform Surgical Operationmentioning

confidence: 99%

“…At present, MC-PMMA have been used and reported in three researches, but the results were mixed. Three studies [46][47][48] were all retrospective including 245 cases. Among of them, 133 cases in MC-PMMA group and 112 case in PMMA group.…”

Section: Reform Surgical Operationmentioning

confidence: 99%

Factors and Strategies for Post-Vertebroplasty Residual Pain from Thoracolumbar Osteoporotic Vertebral Compression Fractures (OVCF): a systematic review.

Tang

Liu

et al. 2021

Preprint

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Purpose Insignificant pain relief (IPR) in short period after vertebroplasty is common, which often disturb doctors and affect patients Therefore, we reviewed systematically relative articles and attempted to get meaningful evidence on factors and strategies for IPR.Methods PubMed, Web of Science, Embase, CNKI, WanFang, and VIP were searched for literatures treating the osteoporotic vertebral compression fractures (OVCFs) with vertebroplasty and assessing the clinical efficacy.Results 817 references were electronically retrieved, 81 full-text papers were screened and 41 studies were included. Twenty-two trials presented factors on IPR, mainly including bone cement related, operation related and patient-related factors. Nineteen studies showed strategies on residual pain, including improving osteoporosis, reforming surgical operation and add other therapies. 16 prospective, 20 retrospective and 5 meta-analyses consisted the systematic review. The date from included studies point to different results, with less risk of bias, were needed to clarify the factors and strategies for residual pain.Conclusions Bone cement distribution and operation error are highly related to the post-vertebroplasty residual pain. Many therapeutic methods could improve pain and rehabilitate function but lacking more high-level evidence due to the insufficient trails.

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“…[28][29][30] Via the modification, bone formation at the interface between the bone cement and host bone could be observed, and secondary fracture was significantly decreased as shown by longterm follow-ups. [31][32][33] Although MC-modified PMMA bone cement has many advantages compared with traditional bone cement, it has not been used for interbody fusion. Moreover, an appropriate biomaterial and applicable operative method need to be developed.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive injectable lumbar interbody fusion with mineralized collagen-modified PMMA bone cement: A new animal model

Kong¹,

Ma²,

Wu³

et al. 2020

Journal of Applied Biomaterials & Functional Materials

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This study was to develop a feasible and safe animal model for minimally invasive injectable lumbar interbody fusion using a novel biomaterial, mineralized collagen-polymethylmethacrylate bone cement (MC-PMMA), with unilateral pedicle screw fixation in an in vivo goat model. Eight goats ( Capra aegagrus hircus) were divided into three groups: MC-PMMA, unmodified commercial-polymethylmethacrylate bone cement (UC-PMMA), and a control group (titanium cage filled with autogenous bone, TC-AB). Each group of goats was treated with minimally invasive lumbar interbody fusion at the L3/L4 and L5/L6 disc spaces (injected for MC-PMMA and UC-PMMA, implanted for TC-AB). The pedicle screws were inserted at the L3, L4, L5, and L6 vertebrae, respectively, and fixed on the left side. The characteristics of osteogenesis and bone growth were assessed at the third and the sixth month, respectively. The methods of evaluation included the survival of each animal, X-ray imaging, and 256-layer spiral computed tomography (256-CT) scanning, imaged with three-dimensional microfocus computed tomography (micro-CT), and histological analysis. The results showed that PMMA bone cement can be extruded smoothly after doping MC, the MC-PMMA integrates better with bone than the UC-PMMA, and all goats recovered after surgery without nerve damage. After 3 and 6 months, the implants were stable. New trabecular bone was observed in the TC-AB group. In the UC-PMMA group a thick fibrous capsule had formed around the implants. The MC-PMMA was observed to have perfect osteogenesis and bone ingrowth to adjacent bone surface. Minimally invasive injectable lumbar interbody fusion using MC-PMMA bone cement was shown to have profound clinical value, and the MC-PMMA showed potential application prospects.

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Clinical outcome comparison of polymethylmethacrylate bone cement with and without mineralized collagen modification for osteoporotic vertebral compression fractures

Cited by 16 publications

References 29 publications

Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Factors and Strategies for Post-Vertebroplasty Residual Pain from Thoracolumbar Osteoporotic Vertebral Compression Fractures (OVCF): a systematic review.

Minimally invasive injectable lumbar interbody fusion with mineralized collagen-modified PMMA bone cement: A new animal model

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