Clinical pharmacokinetic and pharmacodynamic evaluation of transdermal drug delivery systems of salbutamol sulfate

Murthy, S. N. B.; Hiremath, Shobharani R.

doi:10.1016/j.ijpharm.2004.08.018

Cited by 18 publications

(7 citation statements)

References 19 publications

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“…The advantage of prolonged‐release tablets containing SS was reported in clinical studies 6. New prolonged‐release oral dosage forms containing SS include hard capsules, Ventmax ™ (Chiesi Ltd., Cheadle, UK), and tablet forms: Volmax CR ™ (GlaxoSmithKline plc, London, UK) and Vospire ER ™ (Teva Pharmaceuticals, North Wales, Pennsylvania, USA) 7. Both prolonged‐release capsules and tablets containing SS have monographs in the British Pharmacopeia 8.…”

Section: Introductionmentioning

confidence: 99%

Solid‐state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt

Paluch

Tajber

Elcoate

et al. 2011

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Solid‐state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt

Paluch

Tajber

Elcoate

et al. 2011

Journal of Pharmaceutical Sciences

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“…19 Achieving controlled transdermal delivery of SS is challenging, as it is a hydrophilic drug with a pK a of 9.2 and a log P value of 0.11. 20 Therefore, this study was focused on optimizing the factors influencing the preparation of an efficient ethosomal system that could be incorporated into a suitable gel to be easily applied by patients. We wanted to create a system that could control the rate of drug release for 24 hours, with an input rate of~100 μg/h.…”

Section: Introductionmentioning

confidence: 99%

“…We wanted to create a system that could control the rate of drug release for 24 hours, with an input rate of~100 μg/h. 20…”

Section: Introductionmentioning

confidence: 99%

Enhanced transdermal delivery of salbutamol sulfate via ethosomes

2007

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The main objective of the present work was to compare the transdermal delivery of salbutamol sulfate (SS), a hydrophilic drug used as a bronchodilator, from ethosomes and classic liposomes containing different cholesterol and dicetylphosphate concentrations. All the systems were characterized for shape, particle size, and entrapment efficiency percentage, by image analysis optical microscopy or transmission electron microscopy, laser diffraction, and ultracentrifugation, respectively. In vitro drug permeation via a synthetic semipermeable membrane or skin from newborn mice was studied in Franz diffusion cells. The selected systems were incorporated into Pluronic F 127 gels and evaluated for both drug permeation and mice skin deposition. In all systems, the presence of spherical-shaped vesicles was predominant. The vesicle size was significantly decreased (P < .05) by decreasing cholesterol concentration and increasing dicetylphosphate and ethanol concentrations. The entrapment efficiency percentage was significantly increased (P < .05) by increasing cholesterol, dicetylphosphate, and ethanol concentrations. In vitro permeation studies of the prepared gels containing the selected vesicles showed that ethosomal systems were much more efficient at delivering SS into mice skin (in terms of quantity and depth) than were liposomes or aqueous or hydroalcoholic solutions.

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“…Several analytical methods have been reported for the quantification of salbutamol in plasma. HPLC with fluorescence detection (Fowler and Lipworth, 2001;Du et al, 2002;Schmekel et al, 1999;Narasimha Murthy and Hiremath, 2004;Kavita et al, 1999;Loss et al, 2000) has mostly been adopted with a lowest detection limit of 0.1 ng/mL. Ouyang et al (2005) reported an ion chromatography with a direct conductivity detection method for the determination of salbutamol in human plasma, in which the LLOQ was 1 ng/mL.…”

Section: Introductionmentioning

confidence: 99%

Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study

Zhang

Teng

Chen

et al. 2011

Biomedical Chromatography

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A sensitive and selective liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of salbutamol in human plasma and urine, and successfully applied to the pharmacokinetic study of salbutamol in Chinese healthy volunteers after inhalation of salbutamol sulfate aerosol. Salbutamol and the internal standard (IS) acetaminophen in plasma and urine were extracted with ethyl acetate, separated on a C(18) reversed-phase column, eluted with mobile phase of acetonitrile-ammonium acetate (5 m m; 30:70, v/v), ionized by positive ion pneumatically assisted electrospray and detected in the multi-reaction monitoring mode using precursor → product ions of m/z 240.2 → 148.1 for salbutamol and 152 → 110 for the IS. The lower limits of quantitation of salbutamol in human plasma and urine by this method were 0.02 and 1 ng/mL, respectively. The specificity, matrix effect, recovery, sensitivity, linearity, accuracy, precision and several stabilities were validated for salbutamol in human plasma and urine. In conclusion, the validation results showed that this method is robust, specific and sensitive, and can successfully fulfill the requirement of clinical pharmacokinetic study of salbutamol in healthy Chinese volunteers.

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Clinical pharmacokinetic and pharmacodynamic evaluation of transdermal drug delivery systems of salbutamol sulfate

Cited by 18 publications

References 19 publications

Solid‐state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt

Solid‐state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt

Enhanced transdermal delivery of salbutamol sulfate via ethosomes

Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study

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