Clinical Pharmacokinetics of Albendazole in Children With Neurocysticercosis

Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected withGiardia intestinalis

“…The pharmacokinetics of albendazole and albendazole sulphoxide observed in the present study, with or without concomitant praziquantel, were generally in accordance with those previously reported and again demonstrate the rapid-elimination characteristics of the parent drug (Marriner et al, 1986;Okelo et al, 1993;Homeida et al, 1994;Jung et al, 1997). The low systemic bio-availability of albendazole may be explained, in part, by its poor gastrointestinal absorption and by its extensive metabolism, by hepatic and mucosal enzymes, to albendazole sulphoxide and, to a lesser extent, other metabolites.…”

“…The maximum plasma levels of albendazole sulphoxide observed in the present study, in the children who each received 400 mg (i.e. approximately 9-24 mg/kg) albendazole alone, are generally higher than those recorded in children with brain cysticercosis given albendazole at 15 mg/kg (Jung et al, 1997). Moreover, the albendazole-sulphoxide C max and AUC 0-∞ values recorded in the present study (in the children not given praziquantel) are 2-to 3-fold higher than those seen in the five paediatric patients with cystic echinococcosis who were each given 200 or 300 mg albendazole by Okelo et al (1993).…”

“…The main aim of the present study was to investigate the pharmacokinetic parameters of a single dose of albendazole, when given alone and in combination with a single dose of praziquantel, to Thai children with Giardia infection. There appear to have been only two previous pharmacokinetic studies of albendazole in children, one among echinococcosis cases (Okelo et al, 1993) and one among neurocysticercosis cases (Jung et al, 1997).…”

Simultaneous determination of albendazole and its major active metabolite in human plasma using a sensitive and specific liquid chromatographic–tandem mass spectrometric method

“…Due to extensive metabolism, plasma concentration of ABZ was very low after oral administration. Therefore, pharmacokinetics of ABZ and the bioavailability of ABZ formulations have been studied with regard to plasma concentrations of ABZ-SO and ABZ-SO 2 [4][5][6][7][8].…”

High-Performance Liquid Chromatography Determination of Praziquantel in Rat Plasma; Application to Pharmacokinetic Studies

“…From the very beginning different analytical methods were developed by different researchers and reported its level in animals and humans from a biological fluids (plasma, serum), tissue organ extracts. Some of the analytical methods, which include radiometric assay [2] , fluorometric assay [3] , enzyme-linked immunosorbent assay (ELISA) [4] , thinlayer chromatography (TLC), gas chromatography (GC) [5,6] , high-pressure liquid chromatography (HPLC) [7,[8][9][10][11][12][13][14] .…”