Clinical pharmacology of recombinant human luteinizing hormone: Part II. Bioavailability of recombinant human luteinizing hormone assessed with an immunoassay and an in vitro bioassay

Cotonnec, Jean-Yves le; Porchet, HervéClaude; Beltrami, Vanya; Munafo, Alain

doi:10.1016/s0015-0282(97)00502-5

Cited by 45 publications

(19 citation statements)

References 6 publications

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“…Thus, for the r-hFSH study, 300 IU of r-hFSH was sufficient for pharmacokinetic analysis; however for the r-hLH study, 900 IU of r-hFSH was required to provide 450 IU of r-hLH that could be profiled adequately. As linear pharmacokinetics up to 40 000 IU have previously been established for r-hLH 10,11 , the present bioequivalence results can be extrapolated to the lower doses of r-hLH used in clinical practice.…”

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

Bioequivalence of recombinant human FSH and recombinant human LH in a fixed 2 : 1 combination: two phase I, randomised, crossover studies

Picard

Rossier

Papasouliotis

et al. 2008

Current Medical Research and Opinion

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Section: Discussionmentioning

confidence: 76%

“…Previous work has established the pharmacokinetic profiles of follitropin alfa [7][8][9] and lutropin alfa 10,11 . Furthermore, no pharmacokinetic or pharmacodynamic interaction between the two gonadotrophins was detected when follitropin alfa and lutropin alfa were injected in a 1 : 1 ratio once daily over a 7-day period 12 .…”

Section: Introductionmentioning

confidence: 99%

Bioequivalence of recombinant human FSH and recombinant human LH in a fixed 2 : 1 combination: two phase I, randomised, crossover studies

Picard

Rossier

Papasouliotis

et al. 2008

Current Medical Research and Opinion

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“…Although these investigators found that the goodness-of-fit of this alternative model was lower than their original model, other authors have found it useful to fit the i.m. absorption kinetics of several other aqueous drug products such as trovafloxacin [30], pralidoxime [31], or recombinant human luteinizing hormone [32]. Another possible modification is to use two asynchronous inverse-gaussian absorption processes, a strategy that successfully quantified the effect of adrenaline on the uptake of ropivacaine in a thoracic paravertebral or a femoral nerve block [25,26].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Lidocaine Hydrochloride Administered with or without Adrenaline for the Paravertebral Brachial Plexus Block in Dogs

et al. 2017

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Adrenaline is known to prolong the duration of local anesthesia but its effects on the pharmacokinetic processes of local anesthetic drugs are not fully understood. Our objective was to develop a compartmental model for quantification of adrenaline’s impact on the pharmacokinetics of perineurally-injected lidocaine in the dog. Dogs were subjected to paravertebral brachial plexus block using lidocaine alone or adrenalinated lidocaine. Data was collected through a prospective, randomised, blinded crossover protocol performed over three periods. Blood samples were collected during 180 minutes following block execution. Compartmental pharmacokinetic models were developed and their goodness-of-fit were compared. The lowering effects of adrenaline on the absorption of lidocaine were statistically determined with one-sided tests. A one-compartment disposition model with two successive zero-order absorption processes best fitted our experimental data. Adrenaline decreased the peak plasma lidocaine concentration by approximately 60% (P < 0.001), decreased this local anesthetic’s fast and slow zero-order absorption rates respectively by 50% and 90% (P = 0.046, and P < 0.001), which respective durations were prolonged by 90% and 1300% (P < 0.020 and P < 0.001). Lidocaine demonstrated a previously unreported atypical absorption profile following its paravertebral injection in dogs. Adrenaline decreased the absorption rate of lidocaine and prolonged the duration of its absorption.

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“…hCG is characterized by structural similarities with LH, while they share the same receptor, LH/CGR. The factor that distinguishes hCG is the longer half-life of 36 h [11] while the elimination half-life of recombinant LH is estimated to be about 10–12 h [12]. The slower plasma metabolic clearance of hCG consists of a rapid phase in the first 5–9 h following intramuscular (IM) administration and a slower phase in the first 1–1.3 days after administration.…”

Section: Hcg and Assisted Reproductionmentioning

confidence: 99%

Human Chorionic Gonadotropin: The Pregnancy Hormone and More

Theofanakis

Drakakis

Besharat

et al. 2017

IJMS

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To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.

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Clinical pharmacology of recombinant human luteinizing hormone: Part II. Bioavailability of recombinant human luteinizing hormone assessed with an immunoassay and an in vitro bioassay

Cited by 45 publications

References 6 publications

Bioequivalence of recombinant human FSH and recombinant human LH in a fixed 2 : 1 combination: two phase I, randomised, crossover studies

Bioequivalence of recombinant human FSH and recombinant human LH in a fixed 2 : 1 combination: two phase I, randomised, crossover studies

Pharmacokinetics of Lidocaine Hydrochloride Administered with or without Adrenaline for the Paravertebral Brachial Plexus Block in Dogs

Human Chorionic Gonadotropin: The Pregnancy Hormone and More

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