Clinical relevance of rhinovirus infections among adult hospitalized patients

Fíca, Alberto; Dabanch, Jeannette; Andrade, Winston; Bustos, Patricia; Carvajal, Ita; Ceroni, Carolina; Triantafilo, Vjera; Castro, M.; Fasce, Rodrigo

doi:10.1016/j.bjid.2014.10.003

Cited by 20 publications

(28 citation statements)

References 38 publications

(74 reference statements)

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“…Previous studies have reported that the HRV infection rate in hospitals varies from 21% to 41%. 8,11,12 However, this variation is probably accounted for by the differences in age and clinical characteristics of patients analyzed in each study. Although this study included all age groups, a predominance of pediatric patients infected with HRV was observed, mostly younger than 1 year old.…”

Section: Discussionmentioning

confidence: 99%

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Leotte

Trombetta

Faggion

et al. 2017

Jornal de Pediatria (Versão em Português)

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Objectives: To report epidemiological features, clinical characteristics, and outcomes of human rhinovirus (HRV) infections in comparison with other community acquired respiratory virus (CRV) infections in patients hospitalized for two consecutive years. Methods: This was a cross-sectional study. Clinical, epidemiological, and laboratory data of patients hospitalized with acute respiratory syndrome in a tertiary care hospital from 2012 to 2013 were reviewed. Results: HRV was the most common CRV observed (36%, 162/444) and was present in the majority of viral co-detections (69%, 88/128), mainly in association with human enterovirus (45%). Most HRV-infected patients were younger than 2 years (57%). Overall, patients infected with HRV had a lower frequency of severe acute respiratory infection than those infected with other CRVs (60% and 84%, respectively, p = 0.006), but had more comorbidities (40% and 27%, respectively; p = 0.043). However, in the adjusted analysis this association was not significant. The mortality rate within the HRV group was 3%. Detection of HRV was more prevalent during autumn and winter, with a moderately negative correlation between viral infection frequency and temperature (r = −0.636, p < 0.001) but no correlation with rainfall (r = −0.036, p = 0.866). ଝ Please cite this article as: Leotte J, Trombetta H, Faggion HZ, Almeida BM, Nogueira MB, Vidal LR, et al. Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years. J Pediatr (Rio J). 2017;93:294---300.295Conclusion: HRV is usually detected in hospitalized children with respiratory infections and is often present in viral co-detections. Comorbidities are closely associated with HRV infections. These infections show seasonal variation, with predominance during colder seasons. Rinovírus humano; Infecções respiratórias agudas; Vírus respiratório Impacto e sazonalidade da infecção por rinovírus humano em pacientes internados por dois anos consecutivos ResumoObjetivos: Relatar as características epidemiológicas, as características clínicas e os resultados das infecções por rinovírus humano (RVH) em comparação a outras infecções por vírus respiratórios adquiridos na comunidade (VRCs) em pacientes internados por dois anos consecutivos. Métodos: Este foi um estudo transversal. Foram revisados os dados clínicos, epidemiológicos e laboratoriais de pacientes internados com síndrome respiratória aguda em um hospital terciário de 2012 a 2013. Resultados: O RVH foi o VRC mais comum observado (36%, 162/444) e esteve presente na maior parte das codetecções virais (69%, 88/128), principalmente em associação ao enterovírus humano (45%). A maioria dos pacientes infectados por RVH possuía menos de 2 anos (57%). De modo geral, os pacientes com RVH apresentaram uma menor frequência de infecção respiratória aguda grave que os pacientes infectados por outros VRCs (60% e 84%, respectivamente, p = 0,006), porém mais comorbidades (40% e 27%, respectivamente; p = 0,043). Contudo, em uma análise ajustada, essa associação ...

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Section: Discussionmentioning

confidence: 99%

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Leotte

Trombetta

Faggion

et al. 2017

Jornal de Pediatria (Versão em Português)

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“…Estudos anteriores relataram que a taxa de infecção por RVH em hospitais varia de 21%-41%. 8,11,12 Contudo, essa variação é provavelmente explicada pelas diferenças na idade e nas características clínicas dos pacientes analisados em cada estudo. Apesar de este estudo ter incluído todas as faixas etárias, observamos uma predominância de pacientes pediátricos infectados por RVH, em grande parte pacientes com menos de um ano.…”

Section: Discussionunclassified

“…19,20 Os achados de raios X de tórax foram normais em 17%, mostraram infiltrado intersticial em 33% e consolidação pulmonar em 28% dos casos, sem diferença significativa entre os grupos RVH e outros VRCs. Esses padrões são semelhantes aos relatados por Fica et al 11 em adultos internados no Chile. Houve um número significativamente menor de casos de SARI diagnosticado nos pacientes infectados por RVH do que outros VRCs.…”

Section: Discussionunclassified

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Leotte

Trombetta

Faggion

et al. 2017

Jornal de Pediatria

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“…Thus, the proportion of RV may be different in the general population seeking medical care. A few other studies have reported the proportion of adults with RVassociated ARI to be from 4% to 23%; however, these examined specimens that had tested negative for other viruses, 51 had small sample sizes, 52 or selected for subjects presenting with fever, 34,53 thus likely underestimating the prevalence of RV. The rates of RVassociated hospitalization we detected were generally lower than those reported in a similarly designed study of young children in this same geographic region (5 per 1000/y overall for children aged 0-5 years).…”

Section: Discussionmentioning

confidence: 99%

“…14,16,17,20,[26][27][28][29][30][31] The recently described RV-C has been associated with wheezing and more severe respiratory symptoms in children, 32,33 but these findings have been inconsistent and data are limited in adults. 34,35 The impact of the novel RV-C on US adults has not been established, and the association of RV-C with asthma and COPD is unclear.…”

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confidence: 99%

Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults

Miller

Linder

Kraft

et al. 2016

Journal of Allergy and Clinical Immunology

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Background Rhinovirus is linked to asthma exacerbations and chronic obstructive pulmonary disease exacerbations in adults. The severity and rates of rhinovirus acute respiratory illnesses (ARI) in adults are uncertain. Objectives We determined rhinovirus-associated ARI rates in adults presenting for care in multiple settings and identified factors associated with rhinovirus detection. Methods This prospective, population-based cohort enrolled Tennessee residents ≥18 years old in the emergency department (ED), outpatient clinics, or hospitalized for ARI December 2008-May 2010. Nasal/throat swabs were collected and tested for rhinovirus and other viruses by RT-PCR. Rates of ED visits and hospitalizations were calculated and rhinovirus-positive and -negative patients were compared. Results Among 2351 enrollees, rhinovirus was detected in 247 (11%). There were 7 rhinovirus-associated ED visits and 3 hospitalizations per 1000 adults annually. Patients with rhinovirus, compared to virus-negative ARI, were more likely to present with wheezing (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.23-2.35, p<0.001), to be a current smoker (OR 2.31, CI 1.68-3.19) or live with a smoker (OR 1.72, CI 1.10-2.67), have a history of chronic respiratory disease (OR 1.61, CI 1.17-2.22), and were less likely to be hospitalized versus seen in the outpatient setting (OR 0.58, CI 0.41-0.83). Conclusion Rhinovirus is associated with a substantial number of ED visits and hospitalizations for ARI in adults. There may be modifiable factors that can reduce the likelihood of presenting with rhinovirus-associated ARI.

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Clinical relevance of rhinovirus infections among adult hospitalized patients

Abstract: Human rhinovirus infections in elderly patients with co-morbid conditions are associated with hospitalizations, requiring critical or semi-critical antibiotics use. A high CURB-65 score was associated to in-hospital mortality.

Cited by 20 publications

References 38 publications

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults

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