Clinical Significance of Serum Cytokine Measurements in Untreated Colorectal Cancer Patients: Soluble Tumor Necrosis Factor Receptor Type I &amp;ndash; An Independent Prognostic Factor

Kamińska, Janina; Nowacki, Marek P.; Kowalska, M; Rysińska, A; Chwaliński, Maciej; Fuksiewicz, Małgorzata; Michalski, Wojciech; Chechlińska, Magdalena

doi:10.1159/000086951

Cited by 92 publications

(82 citation statements)

References 26 publications

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“…Our findings are supported by previous studies [32] , exploiting the potential clinical significance of serum IL-8 measurements in untreated CRC patients in comparison to healthy volunteers. Circulating IL-8 serum concentrations revealed a significant correlation with the clinical stage of CRC, bowel wall invasion and liver metastasis [32,33] .…”

Section: Discussionsupporting

confidence: 91%

“…Circulating IL-8 serum concentrations revealed a significant correlation with the clinical stage of CRC, bowel wall invasion and liver metastasis [32,33] . Our results are also well in line with the outcome of recent surveys which compared the expression of a number of different chemokines and growth factors in a panel of arbitrarily chosen CRC specimens with normal mucosa by use of ELISA.…”

Section: Discussionmentioning

confidence: 97%

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Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

107

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AIM:To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM).METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16).RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION:Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

107

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“…High levels are associated with systemic inflammatory response syndrome, which can result in multiple organ failure in the worst case scenario (20,22). All patients had elevated cytokine levels prior to treatment, which is in line with previous reports on patients with advanced cancer (41)(42)(43). Taking into account the detected side effects and cytokine data, it seems reasonable to propose that ICOVIR-7 treatment was well tolerated at the dose range used.…”

Section: Discussionsupporting

confidence: 85%

Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Nokisalmi

Pesonen

Escutenaire

et al. 2010

Clinical Cancer Research

102

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Purpose: Twenty-one patients with cancer were treated with a single round of oncolytic adenovirus ICOVIR-7. Experimental Design: ICOVIR-7 features an RGD-4C modification of the fiber HI-loop of serotype 5 adenovirus for enhanced entry into tumor cells. Tumor selectivity is mediated by an insulator, a modified E2F promoter, and a Rb-binding site deletion of E1A, whereas replication is optimized with E2F binding hairpins and a Kozak sequence. ICOVIR-7 doses ranged from 2 × 1010 to 1 × 1012 viral particles. All patients had advanced and metastatic solid tumors refractory to standard therapies. Results: ICOVIR-7 treatment was well tolerated with mild to moderate fever, fatigue, elevated liver transaminases, chills, and hyponatremia. One patient had grade 3 anemia but no other serious side effects were seen. At baseline, 9 of 21 of patients had neutralizing antibody titers against the ICOVIR-7 capsid. Treatment resulted in neutralizing antibody titer induction within 4 weeks in 16 of 18 patients. No elevations of serum proinflammatory cytokine levels were detected. Viral genomes were detected in the circulation in 18 of 21 of patients after injection and 7 of 15 of the samples were positive 2 to 4 weeks later suggesting viral replication. Conclusions: Overall, objective evidence of antitumor activity was seen in 9 of 17 evaluable patients. In radiological analyses, 5 of 12 evaluable patients had stabilization or reduction in tumor size. These consisted of one partial response, two minor responses and two cases of stable disease, all occurring in patients who had progressive disease before treatment. In summary, ICOVIR-7 treatment is apparently safe, resulting in anticancer activity, and is therefore promising for further clinical testing. Clin Cancer Res; 16(11); 3035–43. ©2010 AACR.

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“…We and others have previously shown elevated concentrations of several circulating cytokines and soluble cytokine receptors in patients with colorectal carcinoma, sarcoma and other malignancies [5, 6, 10, 11,18,19,20]. Similar arrays of elevated circulating pro-inflammatory and pro-angiogenic cytokines as well as those initially identified as hematopoietic cytokines were found during surgical wound healing [21, 22], after extensive injuries [23, 24] and in chronic inflammations [25,26,27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of cytokines and soluble cytokine receptors have been found to correlate with the clinicopathological features of various lymphoid and non-lymphoid neoplasms, as well as with the response to treatment and survival of patients [3,4,5,6,7,8,9,10,11,12]. Despite recent advances in diagnostic and therapeutic measures, the prognosis of patients with non-small cell lung carcinoma (NSCLC) remains poor.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Serum Levels of Cytokines and Cytokine Receptors in Patients with Non-Small Cell Lung Cancer, and Correlations with Clinicopathological Features and Prognosis

Kamińska¹,

Kowalska²,

Kotowicz³

et al. 2006

Oncology

113

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Objectives: Cytokines are potential new serum markers, especially desirable for malignancies with poor prognosis like non-small cell lung cancer (NSCLC). Methods: Cytokines, tumor necrosis factor α (TNFα), interleukin (IL)-6 and IL-8, soluble TNF (sTNF) RI, sTNF RII, soluble IL-2 receptor-α, IL-1 receptor antagonist (IL-1ra), IL-10, vascular endothelial growth factor, basic fibroblast growth factor, and macrophage (M-CSF) and granulocyte colony-stimulating factor, as well as tumor markers – carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and CYFRA 21.1 – were assessed in the sera of 103 untreated NSCLC patients, and these cytokines and tumor markers were refered to clinical parameters of the disease and to the overall survival of patients evaluated during a 6-year follow-up. Results: Most of the factors analyzed were found to be elevated in the sera of NSCLC patients, and increases in IL-6, IL-8 and sTNF RI were noted in the greatest proportion of stage I patients. Most cytokine/cytokine receptor levels revealed higher sensitivity than the standard tumor markers; IL-6 and IL-1ra levels were significantly different in patients with squamous cell versus adenocarcinoma; IL-6 and IL-10 were related to the tumor size, while IL-6 and M-CSF levels significantly increased with disease progression. A significant prognostic value of pretreatment serum M-CSF and CEA levels in NSCLC patients has been shown, but only M-CSF proved to be an independent prognostic factor. Conclusions: Increased pretreatment serum M-CSF level is a significant independent predictor of poor survival in patients with NSCLC.

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Clinical Significance of Serum Cytokine Measurements in Untreated Colorectal Cancer Patients: Soluble Tumor Necrosis Factor Receptor Type I – An Independent Prognostic Factor

Cited by 92 publications

References 26 publications

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Pretreatment Serum Levels of Cytokines and Cytokine Receptors in Patients with Non-Small Cell Lung Cancer, and Correlations with Clinicopathological Features and Prognosis

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