Clinical significance of soluble interleukin 2 receptor for monitoring the diseases associated with activated lymphocytes and viral infections

Soluble Interleukin-2 Receptor as an Indicator of Immunological Disturbance Found in Silicosis Patients

“…Additionally, recent studies have indicated that a rise in serum sIL-2R levels in apparently healthy individuals could be an important early signal of neoplastic, autoimmune or inflammatory disease (19)(20)(21)(22)(23). Furthermore, a positive correlation between disease activity and serum sIL-2R levels has been reported since early 1990. sIL-2R is produced by proteolytic cleavage on activated T cell membranes.…”

“…Markedly elevated serum sIL-2R levels have been reported as being characteristic of certain hematologic malignancies, such as adult T-cell leukemia and hairy cell leukemia, reflecting tumor burden and response to therapy (19)(20)(21)(22)(23). Additionally, recent studies have indicated that a rise in serum sIL-2R levels in apparently healthy individuals could be an important early signal of neoplastic, autoimmune or inflammatory disease (19)(20)(21)(22)(23). Furthermore, a positive correlation between disease activity and serum sIL-2R levels has been reported since early 1990. sIL-2R is produced by proteolytic cleavage on activated T cell membranes.…”

“…IL-2Ra is also present as a naturally occurring soluble molecule (sIL-2R) (19)(20)(21)(22)(23). Markedly elevated serum sIL-2R levels have been reported as a characteristic feature of certain hematologic malignancies such as human T lymphotropic retrovirus type I-associated adult T-cell leukemia and hairy cell leukemia, reflecting tumor burden and response to therapy.…”

“…The high-affinity interleukin-2 receptor (IL-2R) is a multichain receptor which possesses at least three IL-2 binding chains: IL-2Ra (55 kDa), which binds the monoclonal antibody anti-Tac, IL-2R~(75 kDa) and 11-2Ry (64 kDa). IL-2Ra is also present as a naturally occurring soluble molecule (sIL-2R) (19)(20)(21)(22)(23). Markedly elevated serum sIL-2R levels have been reported as a characteristic feature of certain hematologic malignancies such as human T lymphotropic retrovirus type I-associated adult T-cell leukemia and hairy cell leukemia, reflecting tumor burden and response to therapy.…”

“…Markedly elevated serum sIL-2R levels have been reported as a characteristic feature of certain hematologic malignancies such as human T lymphotropic retrovirus type I-associated adult T-cell leukemia and hairy cell leukemia, reflecting tumor burden and response to therapy. Furthermore, recent studies have indicated that a rise in serum sIL-2R levels in apparently healthy individuals could be an important early signal of neoplastic, autoimmune or inflammatory disease (19)(20)(21)(22)(23).…”