Clinical significance of urinary plasminogen and fibrinogen gamma chain as novel potential diagnostic markers for non-small-cell lung cancer

Zhang, Wencheng; Gao, Zhouyong; Zeng, Guang; Xie, Hui; Wang, Zhibin; Liu, Ning; Wang, Guangshun

doi:10.1016/j.cca.2019.11.022

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…Three studies investigated miRNA and lncRNA, showing that both analytes could be useful in NSCLC detection and monitoring 155‐157 . The diagnostic potential of proteins 158‐163 and metabolites 164‐166 for lung cancer was evidenced in multiple studies. Urinary midkine, 163 N1, N12‐diacetylspermine 167 and collagen XXII 168 were shown to separately have diagnostic and prognostic potential.…”

Section: Resultsmentioning

confidence: 99%

Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods

Jordaens

Zwaenepoel

Tjalma

et al. 2023

Intl Journal of Cancer

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The aim of this review was to explore the status of urine sampling as a liquid biopsy for noninvasive cancer research by reviewing used preanalytical parameters and protocols.We searched two main health sciences databases, PubMed and Web of Science. From all eligible publications (2010-2022), information was extracted regarding: (a) study population characteristics, (b) cancer type, (c) urine preanalytics, (d) analyte class, (e) isolation method, (f ) detection method, (g) comparator used, (h) biomarker type, (i) conclusion and (j) sensitivity and specificity. The search query identified 7835 records, of which 924 unique publications remained after screening the title, abstract and full text. Our analysis demonstrated that many publications did not report information about the preanalytical parameters of their urine samples, even though several other studies have shown the importance of standardization of sample handling. Interestingly, it was noted that urine is used for many cancer types and not just cancers originating from the urogenital tract. Many different types of relevant analytes have been shown to be found in urine. Additionally, future considerations and recommendations are discussed: (a) the heterogeneous nature of urine, (b) the need for standardized practice protocols and (c) the road toward the clinic. Urine is an emerging liquid biopsy with broad applicability in different analytes and several cancer types. However, standard

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Section: Resultsmentioning

confidence: 99%

Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods

Jordaens

Zwaenepoel

Tjalma

et al. 2023

Intl Journal of Cancer

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“…FGG is a subunit of fibrinogen with a pivotal role in coagulation, inflammation [ 71 , 72 ], and cancerogenesis [ 73 , 74 ]. It has been proposed as diagnostic markers in several diseases (e.g., non-small-cell lung cancer [ 75 ], bladder cancer [ 76 ]). TTR is a carrier of thyroid hormone and retinol in plasma, and cerebrospinal fluid [ 77 ] is an important nutrition indicator, a predictive marker for liver function [ 78 ], and a biomarker of several oxidative stress-related human diseases [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

et al. 2021

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Exosomes and other small extracellular vesicles (EVs) are potential sources of cancer biomarkers. Plasma-derived EVs have not yet been studied in pediatric Hodgkin lymphoma (HL), for which predictive biomarkers of relapse are greatly needed. In this two-part proteomic study, we used two-dimensional difference gel electrophoresis (2D-DIGE) followed by liquid chromatography–tandem mass spectrometry (LC–MS/MS) to analyze EV proteins of plasma collected at diagnosis from children with nodular sclerosis HL, relapsed or not. EVs isolated using membrane affinity had radii ranging from 20 to 130 nm and contained the programmed cell death 6-interacting (ALIX) and the tumor susceptibility gene 101 (TSG101) proteins, whereas calnexin (CANX) was not detected. 2D-DIGE identified 16 spots as differentially abundant between non-relapsed and relapsed HL (|fold change| ≥ 1.5, p < 0.05). LC–MS/MS identified these spots as 11 unique proteins, including five more abundant in non-relapsed HL (e.g., complement C4b, C4B; fibrinogen γ chain, FGG) and six more abundant in relapsed HL (e.g., transthyretin, TTR). Shotgun LC–MS/MS on pooled EV proteins from non-relapsed HL identified 161 proteins, including 127 already identified in human exosomes (ExoCarta data). This EV cargo included 89 proteins not yet identified in exosomes from healthy plasma. Functional interrogation by the Database for Annotation, Visualization and Integrated Discovery (DAVID) revealed that the EV proteins participate in platelet degranulation and serine-type endopeptidase activity as the most significant Gene Ontology (GO) biological process and molecular function (p < 0.01).

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“…A similar trend was observed in urine of NSCLC patients vs healthy individuals (P = 0.000). PLG and FGG proteins are therefore potential markers for NSCLC diagnosis 16 . Particular, PLG expression is associated with favorable prognostic in patients with advanced grade III/IV FIGO) (advanced ovarian cancer) 17 .…”

Section: Discussionmentioning

confidence: 99%

Identification of potential core genes in colorectal carcinoma and key genes in colorectal cancer liver metastasis using bioinformatics analysis

Niu

Gao

2021

Sci Rep

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Colorectal carcinoma (CRC) is one of the most prevalent malignant tumors worldwide. Meanwhile, the majority of CRC related deaths results from liver metastasis. Gene expression profile of CRC patients with liver Metastasis was identified using 4 datasets. The data was analyzed using GEO2R tool. GO and KEGG pathway analysis were performed. PPI network of the DEGs between 1 and 2 gene sets was also constructed. The set 1 is named between primary CRC tissues and metastatic CRC tissues. The set 2 is named between primary CRC tissues and normal tissues. Finally, the prognostic value of hub genes was also analyzed. 35 DEGs (set 1) and 142 DEGs (set 2) were identified between CRC liver metastatic cancer patients. The PPI network was constructed using the top 10 set 1 hub genes which included AHSG, SERPINC1, FGA, F2, CP, ITIH2, APOA2, HPX, PLG, HRG and set 2 hub genes which included TIMP1, CXCL1, COL1A2, MMP1, AURKA, UBE2C, CXCL12, TOP2A, ALDH1A1 and PRKACB. Therefore, ITIH2 might represent the potential core gene for colon cancer liver metastasis. COL1A2 behaves as a key gene in colorectal carcinoma.

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Clinical significance of urinary plasminogen and fibrinogen gamma chain as novel potential diagnostic markers for non-small-cell lung cancer

Cited by 11 publications

References 38 publications

Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods

Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Identification of potential core genes in colorectal carcinoma and key genes in colorectal cancer liver metastasis using bioinformatics analysis

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