Clinical Studies on KW-1062

Abstract

KW-1062 120 mg was intramuscularly administered to five healthy adult volunteers. After 30 minutes, they presented 7.28 ig/m1 of peak blood concentration. Mean recovery rate in urine was 84.5% for 24 hours.When administered to three healthy adult volunteers every 12 hours for 5 days, no accumulation of the drug in blood was observed.Overall clinical efficacy rate of KW-1062 was 71.6% in the treatment of 95 cases with respiratory tract infections. 72.2% of 36 patients with chronic bronchitis or panbronchitis and 69.0% of 42 patients with pneumonia or bronchopneumonia responded well to the drug.Side effects were encountered with 11 cases (9.8%). The results obtained suggest that the drug is useful in the treatment of respiratory tract infections due to gram-negative bacilli.

Multiple-Dose Pharmacokinetics in Serum and Sputum of Sagamicin Administered Intramuscularly to Patients

“…Clini cal trials confirmed these data [6]. Phar macokinetic data available in the litera ture are mainly on mice, rats and dogs [7][8][9][10] and only some investigations have been made on healthy human subjects or patients, and only with single-dose admin istration [11][12]. The purpose of this study was therefore to investigate the pharmaco kinetic properties of this compound after single-and multiple-dose administration during a period of 7 days of therapy in a group of hospitalized patients.…”