Clinical Translation in Tissue Engineering—The Surgeon’s View

Dlaska, Constantin Edmond; Andersson, Gunnar; Brittberg, Mats; Suedkamp, Norbert P.; Raschke, Michael J.; Schuetz, Michael

doi:10.1007/s40610-015-0013-3

Cited by 19 publications

(20 citation statements)

References 111 publications

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“…The main objective of tissue engineering is to restore and improve the function of the tissues by preparing porous three-dimensional scaffolds, and seeding them with cells and growth factors [ 2 ]. These three things (scaffolds, cells, growth factors) are known as “the tissue-engineering triad”, and this system is set up in an appropriate environment in a bioreactor [ 3 , 4 ]. The term “tissue engineering”, where engineering and the life sciences are interconnected, was introduced in 1988 in the National Science Foundation workshop as “the application of principles and methods of engineering and life sciences towards the fundamental understanding of structure–function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve tissue function.” Langer and Vacanti used this term in a review article published in Science in 1993 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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“…"Engineered" Therapies Tissue engineering refers to the manipulation of cells and tissues. Historically, this research has focused on regaining tissue functionality, such as limb restoration in cases of traumatic amputation [150]. However, the expansion of "engineered therapy" use into medical sub-specialties such as oncology has introduced the possibility of wider application in all fields, including modulation of the immune system following trauma.…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lowry

Herzig

Christy

et al. 2021

Stem Cell Rev and Rep

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“…This may be a major reason why there has been so much difficulty in obtaining clinical success with these processes (Dlaska, 2015).…”

Section: Standard Tests For Biological Safetymentioning

confidence: 99%

Assessing the triad of biocompatibility, medical device functionality and biological safety

Williams

2020

Med Devices & Sens

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Biomaterials, defined as 'materials designed to take a form that can direct, through interactions with living systems, the course of any therapeutic or diagnostic procedure' (Zhang & Williams, 2019), are used in an increasing number of medical applications (Williams, 2014a). From both engineering and regulatory perspectives, the 'form' that the biomaterials take is usually referred to as a 'device'; the interaction with living systems may occur in vivo or ex vivo. The devices have functions that range from mechanical (joint replacements, heart valves), optical (intra-ocular lenses) and electrical (cardiac pacemakers, deep brain stimulators) to those of complex systems that may incorporate the delivery of molecules to the body (prolonged release of drugs) or involve diagnostic character (imaging contrast agents, continuous glucose measurement).Of all the required properties of the biomaterials and devices, two are of profound importance. These are biocompatibility and functionality. Biocompatibility, defined as 'the ability of a material to perform with an appropriate host response in a specific application', (Zhang & Williams, 2019) encompasses all types of interaction that can occur between the material / device and the host. These interactions can be considered negatively in the sense that they may inhibit the appropriate host response, for example being responsible for blood clots forming within intravascular devices, or positively if they promote superior host responses, for example enhanced bonding with bone in orthopaedic devices. The full spectrum of potential mechanisms of biocompatibility has not yet been identified, but much progress has been made in recent years (Williams 2008;Williams 2017a;Villanueva-Flores et al. 2020). It is difficult to itemize the required functionality characteristics of medical devices since they vary from one applications to another,

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Clinical Translation in Tissue Engineering—The Surgeon’s View

Cited by 19 publications

References 111 publications

Fabrication of Scaffolds for Bone-Tissue Regeneration

Fabrication of Scaffolds for Bone-Tissue Regeneration

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Assessing the triad of biocompatibility, medical device functionality and biological safety

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