Clinical uses of starch gel electrophoresis with special reference to leukaemia

Latner, A. L.; Zaki, Angel Habib

doi:10.1016/0009-8981(60)90084-x

Cited by 26 publications

(8 citation statements)

References 5 publications

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“…Previous studies [Latner and Zaki, 1960;Peacock, 1966;Naik et al, 1979] have shown increased frequencies of the Hp' gene and the Hpl-1 type among leu kemia patients. In the present study the patients had a higher Hp1 frequency (0.418) than the controls (0.373).…”

Section: Resultsmentioning

confidence: 99%

Haptoglobin Groups and Leukemia

Fröhlander

1984

Hum Hered

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Section: Resultsmentioning

confidence: 99%

Haptoglobin Groups and Leukemia

Fröhlander

1984

Hum Hered

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“…Earlier studies on the possible associa tion between serum HP and leukaemia [Latner and Zaki, I960;Galatius-Jensen, 1962;Peacock, 1966;Papiha et a!., 1974;Naik et al, 1979 andFrohlander, 1984] had reported an increased frequency of HP1 in patients compared with controls, but in only two [Latner and Zaki, 1960;Peacock, 1966] did it reach the level of sig nificance.…”

Section: Introductionmentioning

confidence: 99%

Associations between the Two Serum Proteins Haptoglobin and Transferrin and Leukaemia

Mitchell

Carzino

Janardhana³

1988

Hum Hered

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Haptoglobin and transferrin (TF) types were determined for 134 patients with leukaemia of the four most common types: acute lymphocytic (ALL), chronic lymphocytic (CLL), acute myelocytic (AML) and chronic myelocytic leukaemia (CML). The phenotype HPl was found to have an increased incidence in the total patient group due to an increased incidence in those with AML, ALL and CML compared with controls, but not in those with CLL. Although tests of association applied to each of the samples of the four common types of leukaemia produced no significant χ2 values, they did indicate that the relative incidence (RI) was just under 2 for the groupings of the acute forms ALL and AML, the myelocytic forms AML and CML and for the combination of ALL, AML and CML, respectively. All these associations were statistically significant (p < 0.05). Analysis of TF subtypes and leukaemia indicated a significantly increased frequency of TF C1C1 among leukaemia patients compared with controls (p < 0.005). Analysis of the samples of each of the four common types suggested that while the RI was raised in all but ALL patients, the association was significant only in AML patients (p < 0.05). However, when the two myelocytic types were combined the RI was 2.3 and the association was highly significant (p < 0.005). No such association could be detected in the lymphocytic forms.

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“…Since Latner and Zaki [1] re ported an association between the HP1-1 type and leukemia, many diseases have been found to be associated with certain HP phenotypes. In 1978 Blenk and Junge [2] reported a signif icant increase of H PI-1 in patients with cirrho sis of the liver compared to a control group.…”

Section: Introductionmentioning

confidence: 99%