Clinical utility of FDG PET/CT in acute complicated pyelonephritis—results from an observational study

Wan, Chih-Hsing; Tseng, Jing-Ren; Lee, Ming-Hsun; Yang, Lan-Yan; Yen, Tzu-Chen

doi:10.1007/s00259-017-3835-9

Cited by 14 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-6 and other neutrophilic activation markers to differentiate UTI and asymptomatic bacteriuria have been evaluated in elderly patients, but have yet to be tested in FN (18,19). Positron Emission Tomography, Computed Tomography and MRI, have proven to be useful tools in UTI diagnosis (20,21). Although it might be di cult to propose additional imaging to hematological patients with FN, who are frequently exposed to ionizing rays, these techniques might be interesting in differentiating asymptomatic bacteriuria and UTI.…”

Section: Discussionmentioning

confidence: 99%

Outcome of febrile neutropenic patients treated for bacteriuria in hematology

Delaye

Diaz

Vallée

et al. 2023

Support Care Cancer

View full text Add to dashboard Cite

IntroductionPositive urine sample is a frequent nding in post-chemotherapy febrile neutropenia (FN) and can lead to prolonged antibiotic therapy. The aim of this study was to assess the outcome of bacteriuria episodes in FN patients receiving targeted antibiotic therapy. Materials and methodsA multicentric retrospective study was conducted over a four-year period (2014)(2015)(2016)(2017)(2018)(2019). All consecutive rst bacteriuria episodes (≤2 bacteria with at least ≥10 3 CFU/mL) during FN in hospitalized adult patients for hematological malignancies were included. Relapse and recurrence were de ned by fever or urinary tract symptoms (UTS) with the same bacterial subspecies in urine occurring ≤ 7 days and ≤30 days, respectively, after antibiotic discontinuation. Mortality rate was determined at 30 days. Targeted antibiotic therapy ≤10 days for women and ≤14 for men was considered as short course. ResultsAmong 97 patients, 105 episodes were analyzed; 67.6% occurred in women, 41.9% in AML patients, 17.1% were bacteremic, 14.2% presented with UTS, and 61.9% were treated with short-course antibiotic treatment. One death was reported. In men, no relapse/recurrence was noted, even in the short-course antibiotic group. In women, 2.8% of episodes treated with short-course antibiotic led to relapse or recurrence. ConclusionsRelapse, recurrence, and mortality were uncommon events in FN patients experiencing bacteriuria episode, whatever the antibiotic duration. To distinguish asymptomatic bacteriuria from infection remained challenging in women. In men, the withdrawal of systematic urinalysis at onset of FN could lead to insu cient bacteriuria diagnosis and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcome of febrile neutropenic patients treated for bacteriuria in hematology

Delaye

Diaz

Vallée

et al. 2023

Support Care Cancer

View full text Add to dashboard Cite

show abstract

“…The use of 18 F-FDG PET/CT has been explored in infective endocarditis [2,3], febrile neutropenia [4], Staphylococcus aureus bacteremia [5], vascular graft infections [6], and invasive fungal infections [7] among several other applications [8,9]. The diagnostic yield and clinical impact of 18 F-FDG PET/CT varies based on context and has ranged widely [4,5,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection

et al. 2022

View full text Add to dashboard Cite

Few studies have aimed to capture the full spectrum of 18fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) use for evaluation of infections in a real-world context. We performed a retrospective chart review of hospitalized patients who underwent 18F-FDG PET/CT for the workup of infection between April, 2013 and September, 2019. The clinical indications for and impact of 18F-FDG PET/CT on diagnostic and antimicrobial management were evaluated across different infectious indications. Sixty-one patients met the inclusion criteria. The most common indication was identifying a source of a known infection (46%), followed by fever of unknown etiology (FUE)/fever of unknown origin (FUO) (38%), and other (16%). 18F-FDG PET/CT was determined to have had a diagnostic or management clinical impact for a total of 22 patients (36%) including 12/28 (43%) of patients with known infection, 7/23 (30%) of patients with FUE/FUO, and 3/10 (30%) of patients with other indications. 18F-FDG PET/CT confirmed suspected prosthetic endovascular infection for 6/16 (38%) patients. In this study,18F-FDG PET/CT led to a clinical impact on diagnostic and treatment management of hospitalized patients across a variety of syndromes and particularly for source identification in the setting of known infection.

show abstract