Clinical validation of the “7 × 7” questionnaire for patients with functional gastrointestinal disorders

Abstract

Background and Aim Physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the “7 × 7” questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of functional gastrointestinal disorders, using the Clinical Global Impressions scale as the reference standard. Methods Fifty inpatients aged from 18 to 64 with a confirmed diagnosis of irritable bowel syndrome (26 patients, 52%), functional dyspepsia (15 patients, 30%), or both (9 patients, 18%) were prospectively enrolled in the study. We used both the 7 × 7 questionnaire and the Clinical Global Impressions scale before and after 28 days of stable treatment. Results Our study revealed a significant correlation between the 7 × 7 questionnaire and the Clinical Global Impressions scale results in assessment of severity of the clinical symptoms and their dynamics during treatment. The 7 × 7 questionnaire showed sensitivity of 74.5% and specificity of 54.1% for evaluating patients with mild to severe disease and 66.6% and 76%, respectively, for evaluating patients with moderate to severe disease. The Cronbach's alpha coefficient was 0.719. The intraclass correlation coefficient among participants in whom the condition remained the same was 0.973 (12 participants [24.5%]). Conclusions The 7 × 7 questionnaire is a convenient, sensitive, and reliable tool for assessing the severity of symptoms and treatment efficacy in people with functional gastrointestinal disorders.

Pathogenetic approach to the treatment of functional disorders of the gastrointestinal tract and their intersection: Results of the Russian Observation Retrospective Program COMFORT

“…23 Used as a tool for assessing the severity of symptoms of FD, the "7*7" questionnaire is convenient for the doctors and does not take much time from the patients. 24 According to the experience of practicing physicians, a detailed interview of a patient with FGID cannot take less than 45-60 minutes. 32 The "7*7" questionnaire used in this observational program is able to significantly minimize the time spent by a doctor when there is insufficient time allotted for the examination of the patient.…”

“…The "7*7" questionnaire was developed by the Russian Gastroenterological Association based on clinical symptoms described in the Rome III criteria and recommended for use by gastroenterologists in routine practice to assess the presence and severity of the seven main symptoms of FGID observed over the past seven days. 24 The first four domains in the "7*7" questionnaire are considered as symptoms of FD; domains 5 through 7 characterize IBS symptoms.…”

Morphological substantiation of the use of laser and led irradiation in emergent treatment of ulcer complications

“…Marked trend in decrease of the number of patients with peptic ulcer disease requiring surgical treatment, due to the development of the "gold standard" of drug therapy of this disease, based on the discovering etiological and pathogenetic role of Helicobacter pylori. [1][2][3][4] Despite this, peptic ulcer disease -PUD continues to be one of the most urgent problems of surgery. Prevalence of PUD among adult population comprises 6-10%.…”

“…This is especially true of its complicated forms. [2,3,[5][6][7][8][9][10][11][12] Various types of photo-influencing such as local irradiation of ulcers, using low-intensive lasers -LIL, and more recently, LED (Light Emitting Diode) light and intravascular laser irradiation of blood -ILIB widely used in gastroenterology, including complex treatments of urgent complications of ulcers. [1,7,[13][14][15][16][17][18] However, morphological grounds of expediency of using particular types of photo-influencing and methods for their use in the treatment of urgent complications of ulcers are not clear enough.…”

Prednisolone plus S-adenosil-l-methionine in severe alcoholic hepatitis

“…This situation is accompanied by severe mitochondrial depletion of glutathione, the primary antioxidant in cells. Furthermore, hepatocytes are much more sensitive to TNF-a when their antioxidant reserves are low [3]. Combination therapy with an antioxidant and glucocorticoids would have the advantage of both acting on the inflammatory process and reconstituting cellular glutathione reserves [4].…”