Environmental pollution has become the major challenge not only for developing countries but also for developed ones Worldwide. In addition to the pharmaceutical, leather, chemicals, food and paper industries teaching, research and healthcare institutions are also the significant sources of different types of Non-hazardous as well as hazardous wastes. Therefore, a simple and implementable guideline for cleaning and waste disposal services in such institutions require strict adherence to applicable policies and procedures. Research and healthcare waste (RHCW) management is a joint effort among Research Laboratory Personnel, Healthcare Facilitator, Building Services Personnel and Local Environmental Health and Safety Personnel. As Pakistan is among the developing countries situated in South Asia therefor most of the institutes including teaching, research and healthcare try to follow the WHO guidance or try to manage hazardous as well as non-hazardous wastes at self-planned strategies. The major goal of this comprehensive review is to compile the reference data regarding the different types of waste generated in teaching, research and healthcare institutes, and specific strategy to manage such wastes. Although, most of the local Government bodies and Institutional bodies are trying to handle the wastes at their own levels by following different protocols but introducing a protocol at National level is the need of current era to fight against environmental pollutants.