Clinically comparable impedimetric immunosensor for serum alkaline phosphatase detection based on electrochemically engineered Au-nano-Dendroids and graphene oxide nanocomposite

Mahato, Kuldeep; Purohit, Buddhadev; Chandra, Pranjal

doi:10.1016/j.bios.2019.111815

Cited by 84 publications

(34 citation statements)

References 24 publications

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“…Along with biosensors, usage of novel nanomaterials bring a new dimension for the disease-detection techniques, and these techniques are being used widely for its more rapid and high-throughput screening at lower expenses (Roy et al 2019). Many molecular reactions are being applied in the field of biosensors for quick diagnosis process (Mahato et al 2018b;Kumar et al 2019b, c;Purohit et al 2019;Mahato et al 2020). Among them, the microarraybased methodology is broadly used for disease-diagnosing process (Shi et al 2003;Zhu et al 2006).…”

Section: Microarray-based Methodologymentioning

confidence: 99%

Diverse Molecular Techniques for Early Diagnosis of COVID-19 and Other Coronaviruses

Roy

Baranwal

2020

Medical Virology: From Pathogenesis to Disease Control

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Novel coronavirus (SARS-CoV-2) pandemic has impacted the world severely causing millions of positive cases and thousands of fatality cases. Admission of a large number of infected patients in the hospitals is creating daily challenges for medical experts and researchers, such as limited numbers of isolation rooms, less amount of personal protective equipment (PPE), maintaining the hygiene in the hospitals, handling of many clinical samples for tests at the laborites, etc. This disease is mild in most people, but in pre-medical conditions and some elderly people, this virus is affecting majorly and causing fatality. Symptoms of this viral infection include pneumonia, acute respiratory diseases, and multi-organ dysfunction. Considering the situation, early diagnosis of the disease is extremely crucial to control the ongoing epidemic. In this chapter, we have summarized current molecular assays that are in use at many laboratories and hospitals for coronavirus detections. We also discussed molecular diagnosis cases of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) viruses. Many improved and new approaches of molecular tools are involved for the detection of these viruses that are listed down in the table form. We have also reviewed the current challenges/issues arising currently for the effective diagnostics and treatment of the pandemic situation. Further, we put heads together about the future directions

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Section: Microarray-based Methodologymentioning

confidence: 99%

Diverse Molecular Techniques for Early Diagnosis of COVID-19 and Other Coronaviruses

Roy

Baranwal

2020

Medical Virology: From Pathogenesis to Disease Control

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“…In the last few years, our laboratory has developed various POC-immunosensors based on electrochemically engineered nanocomposites modified sensor surface [ [25] , [26] , [27] ]. In a recent work, we have demonstrated a miniaturized label-free electrochemical impedance spectroscopy-based detection of biomarkers using metallic nanoparticles (NPs), electrochemically engineered nano-dendroids, and graphene oxide (GO) nanocomposites.…”

Section: Development Of Impedimetric Immunosensor For Diagnosing Covimentioning

confidence: 99%

“…In a recent work, we have demonstrated a miniaturized label-free electrochemical impedance spectroscopy-based detection of biomarkers using metallic nanoparticles (NPs), electrochemically engineered nano-dendroids, and graphene oxide (GO) nanocomposites. These materials were sequentially deposited over the screen-printed carbon electrode (SPCE) and antibodies against the specific biomarker were immobilized using a bioconjugation process [ 27 ]. GO, a wonder material with exceptional electrical property can be used for the development of high performance COVID-19 biosensing system utilizing such analytical platform.…”

Section: Development Of Impedimetric Immunosensor For Diagnosing Covimentioning

confidence: 99%

“…In a recent study, an RNA-dependent RNA polymerase (RdRp)/helicase (H) genes of SARS-CoV-2, an important marker that does not show any cross-reactivity with other human coronaviruses or respiratory viruses has been utilized for diagnostic purpose [ 31 ]. Thus, if anti-RdRp helicase is successfully immobilized on our recently designed highly conducting surface [ 27 ] it may pave a new way to detect the infection inevitably, due to its robustness and high analytical performance ( Fig. 1 ).…”

Section: Development Of Impedimetric Immunosensor For Diagnosing Covimentioning

confidence: 99%

“…1 Conceptualised schematic representation of the SPCE/NPs/nano-Dendroids/GO/Ab probe fabrication for POC diagnosis of COVID-19 infection (Modified with permission from Ref. [ 27 ]). …”

Section: Development Of Impedimetric Immunosensor For Diagnosing Covimentioning

confidence: 99%

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Miniaturized label-free smartphone assisted electrochemical sensing approach for personalized COVID-19 diagnosis

Chandra

2020

Sensors International

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The COVID-19, coronavirus disease is an infectious disease caused by a novel virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). By March 2020 the novel coronavirus known to cause a pandemic has infected nearly about 119 thousand people and killed more than 4,300 around 114 countries. Apart from the current controversial opinions about the origin, spreading, and sociological impact, it is much more imperative to put a halt to this current situation. Understanding, testing, and early to rapid diagnosis may be now the only key that can contain COVID-19 by “flattening the curve”. Biosensing is the platform that allows rapid, highly sensitive, and selective detection of analytes which in turn can serve the purpose for fast and precise detection of COVID-19. In this article, based on recently reported miniaturized sensing strategies, we hereby propose a promising personalized smartphone assisted electrochemical sensing platform for diagnosis of COVID-19.

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Environmental and Industrial Applications Using Internet of Things (IoT)

Fawzy¹,

Mahmoud²,

Abdelfatah³

2022

A Roadmap for Enabling Industry 4.0 by Artificial Intelligence

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Clinically comparable impedimetric immunosensor for serum alkaline phosphatase detection based on electrochemically engineered Au-nano-Dendroids and graphene oxide nanocomposite

Cited by 84 publications

References 24 publications

Diverse Molecular Techniques for Early Diagnosis of COVID-19 and Other Coronaviruses

Diverse Molecular Techniques for Early Diagnosis of COVID-19 and Other Coronaviruses

Miniaturized label-free smartphone assisted electrochemical sensing approach for personalized COVID-19 diagnosis

Environmental and Industrial Applications Using Internet of Things (IoT)

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