Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study

Bijjaragi, Seema; Kulkarni, Vardendra; Belagatti, Satish L; Kadam, Sunil S

doi:10.5958/j.0976-5506.4.2.050

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“…The commonest cause of pancytopenia in our study was megaloblastic anemia. We found that megaloblastic anemia was also the commonest cause in many other Indian studies like Tilak et al [2], Khodke et al [3], Seema B et al [6], B N Gayathri et al [7], Doshi et al [8] Bhaskar B et al [9] as mentioned in table 07 below. In one study by Khanduri U, et al [10] out of 175 patients with megaloblastic anemia 62% of patients had pancytopenia.…”

Section: Discussionmentioning

confidence: 69%

Clinical Study of Pancytopenia

2016

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Introduction: Pancytopenia is a common and alarming condition encountered by clinicians. We had studied the clinical presentation, laboratory investigations and various etiologies of Pancytopenia. Material and Methods: Study was carried out in a tertiary care centre in western India. A total of 102 patients fulfilling the criteria of pancytopenia were enrolled and studied. Results and conclusion: Megaloblastic anemia was commonest cause of pancytopenia. Easy fatigability and pallor were commonest symptoms and signs respectively. Maximum bleeding manifestations were seen in aplastic anemia and Myelodysplastic syndrome. Available online at: www.ijmrr.in 1557 | P a g e Common over the counter drugs like ibuprofen can also cause pancytopenia. Organophosphorus exposure, cytotoxic drugs, chloramphenicol, methotrexate, phenytoin are commonly implicated [21].Pancytopenia in Indian setting is mostly due to benign because mainly megaloblastic anemia secondary to B12 deficiency caused either by dietary deficiency or treatable condition for example tuberculosis. Emphasis on dietary awareness and supplements wherever required may thus reduce the incidence of pancytopenia and related problems.

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