Clinico-laboratory profile of pediatric HIV in Karnataka

Pol, Ramesh; Shepur, T. A.; Ratageri, Vinod H.

doi:10.1007/s12098-007-0199-3

Cited by 31 publications

(44 citation statements)

References 8 publications

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“…(Table 3) This study is comparable with Diack et al , who found vertical transmission in 99% cases, Pol R et al, reported it in 94.37% cases. 14,18 But in our study vertical transmission was seen in 98.15% cases which is slightly higher than that reported by Merchant RH et al, as 86.6%. 19 Verghese VP et al, found vertical transmission in 87% cases.…”

Section: Fromcontrasting

confidence: 63%

“…This ratio is comparable to study by Madhivanan P et al, who found it to be 2.05:1, Shahab T et al, who found it to be 2.3:1 and Pol R et al, in Karnataka found the ratio as 1.73:1. 14,16,17 This male preponderance might be due to the social structure of our society especially in rural areas where males are given better care than females, from where this study is done.…”

Section: Frommentioning

confidence: 99%

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Clinical profile of human immunodeficiency virus infection in children: an interesting prospective study

Deshmukh¹,

Mogre²,

et al. 2016

Int J Contemp Pediatr

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Background: HIV infection has become a pandemic affecting both industrialized & developing countries. The increase in pediatric HIV infection has had a substantial impact on childhood mortality both in industrialized countries and developing countries. It is believed that this study will motivate research worker to work for further improvement of the disease, clinical presentation, diagnostic measures and management in already existing health care delivery system in a tertiary care centre in the tribal area and which may lead to even better survival and quality of life for these children. With the above background, the study is taken up to find the clinical profile of HIV infection in pediatric population in the study area. Methods: The current hospital based prospective study was carried out in the department of pediatrics, Shri V. N. Government Medical College, Yavatmal (Maharashtra), India from 1st January 2011 to 30th June 2012. 108 cases of HIV attending the pediatric OPD and IPD were included in the study. Importance of test was explained to the parents. HIV was diagnosed by using Standard Protocol. All those who were positive by ELISA, confirmed it by repeat test after 3 months. Western blot was not possible due to non availability of kits. Confirmations of all infections were done as per strategies suggested by WHO. Due to non-availability of specific but expensive test like PCR, p24 antigen assay or HIV Culture, children of PPTCT positive mother were tested on follow up after 18 month age to determine whether the transmission was vertical. Results: Majority (60.18%) cases in this study are below 5 years of age. Maximum cases 33(30.55%) were between 5-10yrs of age and 5 cases (4.62%) were below 18 months. Males 69(63.88%) outnumbered females 39(36.11%) with M: F ratio of 1.76:1. In the present study predominant route of transmission of HIV to the child was by perinatal (vertical) transmission (98.15%). Maximum 64(59.25%) were home delivered cases followed by 29(26.85%) normal hospital delivered and 6(5.55%) LSCS/instrumental delivered cases. In present study 60(55.55%) severe malnutrition (Group III and IV) was the most common examination finding. Of the total 108 cases enrolled in the study, 75 cases had regular follow up for 250 times and 33 cases did not follow up. Majority of follow ups were for respiratory complaints (23.20%) and fever (17.60%). Only 7.20% patients came for follow up were asymptomatic. Most of the follow up were for OI's. In this study, 108 cases of the study group visited 250 times in our hospital. Out of these 90 cases had 212 episodes of OI's and 18 cases had no evidence of OI's. Conclusions: HIV infection is an unpredictable disease in infants, children and adolescent which involves multiple organ system and is characterized by progressive clinical deterioration and ultimate development of severe immune dysfunction with opportunistic infections and secondary cancers resulting in a chronic and very complex illness. HIV infected infant and children now survive to adolescen...

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Section: Fromcontrasting

confidence: 63%

Section: Frommentioning

confidence: 99%

Clinical profile of human immunodeficiency virus infection in children: an interesting prospective study

Deshmukh¹,

Mogre²,

et al. 2016

Int J Contemp Pediatr

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“…These results supported the findings obtained by Pol et al [15] in HIV-infected children in the state of Karnataka who reported tuberculosis as the most common opportunistic infection. While, Shahapur and Bairy [16] reported oral candidiasis and recurrent respiratory tract infection as the commonest opportunistic infections in children infected with HIV in Southern India.…”

Section: Introductionsupporting

confidence: 92%

Speech, language and swallowing difficulties in a child with aids

Narayanan

Kalappa

2017

Acta Oto-Laryngologica Case Reports

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AIDS has a great impact on the modern society as a source of illness and discrimination. It can cause a wide spectrum of disorders which can affect the health and life style of individuals. Globally, the number of individuals with AIDS is increasing and the count of such children is also rising drastically. AIDS caused by HIV is known to invade different systems of the body including the central nervous system thus causing neurological abnormalities/complications in children. Children infected with HIV may present with various types of communication disorders. Speech-language pathologists have investigated and reported the assessment and treatment of HIV-infected individuals in the past. However, studies are limited in the line of profiling the nature of communication and swallowing deficits seen in them. The present case study reports a detailed speech, language and swallowing profile of a child infected with HIV. Effective combination of medical and non-medical treatment for the HIV infection witnessed a great deal of improvement in this child. The importance of care and precautions to be considered while treating such children is highlighted. ARTICLE HISTORY

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“…Pol et al observed 56.3% seropositive children who had weight loss >10%. 16 Difference in weight loss can be explained as study by Pol et al conducted in children >18 months of age. 16 Shah et al observed weight loss >10% in 50% of seropositive cases.…”

Section: Discussionmentioning

confidence: 99%

“…16 Difference in weight loss can be explained as study by Pol et al conducted in children >18 months of age. 16 Shah et al observed weight loss >10% in 50% of seropositive cases. 17 This incidence of more weight loss as compared to our study can be explained as Shah et al conducted their study in children >1 month of age.…”

Section: Discussionmentioning

confidence: 99%

Incidence of HIV, its predictors and risk factors in children

Goyal

Agrawal

Thapar

et al. 2017

Int J Contemp Pediatr

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Background: Children mostly acquire HIV (Human immunodeficiency syndrome) infection from their parents. There is need to know the HIV status of their parents, associated risk factors and predictors so as to make effective strategies to prevent this disease and save the coming/future generation from this deadly disease. The objective of the study was to know incidence of HIV, its predictors and risk factors in children. Study Setting: This is a Hospital based observation study conducted in Department of Pediatrics, Govt. Medical College, Amritsar.Methods: In this study, all patients admitted to Pediatrics department, irrespective of presenting complaints were evaluated for presence of any of risk factors/predictors as mentioned in Proforma and those children having any of risk factors/predictors were selected, consent was taken and undergone detailed clinical evaluation and investigations for HIV.Results: Incidence of HIV in all patients admitted to children ward was 1.21% (27/2227) and children who had one or more risk factor or predictor was 6.58% (27/410). Weight loss, Failure to thrive (44.44%), Diarrhoea (37.03%), Fever (70.37%), Oral Candidiasis (22.2%), Pulmonary Tuberculosis (11.11%) and Generalized Lymphadenopathy (18.51%) were significant predictors in present study. High risk behaviour of parents (37.30%) and mother's HIV positivity (62.92%) were significant high risk factors, however needle prick (18.5%) was also equally significant in present study.Conclusions: Children brought with various signs and symptoms of HIV or born to high risk behaviour practicing parents and/or HIV positive mother, physician must get their patients tested for HIV (as per NACO Guidelines) so that infected children diagnosed early and referred to a specialized centre for treatment and follow up.

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Clinico-laboratory profile of pediatric HIV in Karnataka

Abstract: Vertical transmission was the major route of HIV infection. Persistent fever, cough, loss of appetite and loss of weight were common presenting clinical features. Tuberculosis was the commonest opportunistic infection.

Cited by 31 publications

References 8 publications

Clinical profile of human immunodeficiency virus infection in children: an interesting prospective study

Clinical profile of human immunodeficiency virus infection in children: an interesting prospective study

Speech, language and swallowing difficulties in a child with aids

Incidence of HIV, its predictors and risk factors in children

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