Clinicopathologic Implications of Eukaryotic Initiation Factor 3f and Her‐2/neu Expression in Gastric Cancer

Abstract

Background : To detect the expression of eIF3f and human epidermal growth factor receptor 2 (Her-2)/neu in gastric cancer (GC), correlation with their clinicopathological parameters and the relationship of eIF3f and Her-2/neu in the occurrence and development of GC. Methods : A total of 195 gastrectomy specimens with stage I to III were examined for eIF3f expression by immunohistochemistry and for Her-2/neu expression by fl uorescence in situ hybridization (FISH) with the median follow-up period of 38 months. Results : The positive expression rate of eIF3f in GC and adjacent noncancerous tissue were 33.8% and 59.5%, respectively. eIF3f levels were linked to more advanced tumor stages and likelihood of recurrence (all p < 0.05). The Kaplan-Meier survival curves indicated that decreased expression of eIF3f could serve as a prognosis marker for poor outcome of GC patients (p = 0.04). 15.9% of GC specimens were positive for Her-2/neu, but whose expression was of no correlation with patients' survival. Patients who were positive for Her-2/neu also had high eIF3f expression levels (p = 0.0295). Conclusion : Results suggest that eIF3f may play an important role in recurrence, thus representing a promising predictive marker for the prognosis of GC. But Her-2/neu has no relationship with the prognosis of GC. The clinical signifi cance of eIF3f and Her-2/neu remains to be further investigated. Clin Trans Sci 2015; Volume 8: 320-325

High expression of eIF3d is associated with poor prognosis in patients with gastric cancer

“…Previous studies have demonstrated that eIF3d was overexpressed in several human cancers, such as prostate cancer, 15 colon cancer, 16 and melanoma, 17 while also resistant to chemotherapy. 20 There have been recent studies on expression of other subunits of eIF3 in GC 9 , 25 ; however, the role of eIF3d in GC remains unclear.…”

Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer

“…The high expression of eIF3d is associated with a poor prognosis for patients with gastric cancer 14 . eIF3f expression is significantly decreased in many human cancers, and the decreased expression of eIF3f is a significant factor for a poor prognosis for gastric cancer patients 15–17 .…”

eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer

“…However, there is a discrepancy regarding eIF3f's role in cancer. Studies showed that high expression of eIF3f correlated with advanced gastric tumor stages and likelihood of recurrence [ 31 ] just like CRC, while eIF3f expression is significantly decreased in human pancreatic adenocarcinoma and melanoma, [ 32 ] and eIF3f inhibits tumor growth in cervical cancer model. [ 33 ] Yet, it is not clear how this discrepancy occurs.…”