Clinicopathologic Studies Associated With Xenon Anesthesia

Safety and Efficacy of Xenon in Routine Use as an Inhalational Anaesthetic

“…Xenon offers many advantages over routinely used gases.7 It is non-explosive; probably does not undergo biotransformation; is non-toxic; and offers rapid induction of and recovery from anaesthesia. [8][9][10][11] In experimental studies we have measured tooth-pulp evoked potentials to evaluate pain12,13 and confirmed that the analgesic efficacy of xenon is superior to that of nitrous oxide at the same concentration (70%);14 xenon had no effect on systemic haemodynamics or local organ perfusion15 as measured by means of radionuclidelabelled microspheres. 16,17 The …”

On the Pulmonary Toxicity of Oxygen II.

“…At present,no evidence is available to relate these possibilities to either survival or the extent of lung injury. Speculatively, effects on nerve tissue [8,21,33] would have direct conse quences on ventilation through the neuromuscular apparatus [46]. Once again, the behavior of the mixtures with SF6 pose special problems in this regard ( fig.…”

“…This gas has a molecular weight of 131.3, close enough to that of sulfur hexafluo ride (146) to aid in a rough comparison made necessary by the scanty lit erature on SF6. Xenon seems to have definite effects, including anesthet ic properties at less than 1 atmosphere absolute [7,8,15,24,33,34]. If SF6…”

Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury*

“…The noble gas xenon has been used as a general anesthetic since the 1950s [18,19] but its molecular targets were unknown [20]. Following the discovery that xenon is an NMDA receptor antagonist [21][22][23][24], xenon was shown to be neuroprotective in a number of in vitro and in vivo models of ischemic injury [25][26][27][28][29][30][31][32][33][34] and xenon is currently undergoing clinical trials as a treatment for ischemic brain injury [35,36] and post-operative delirum [37].…”