Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China

Qiu, Miao Zhen; Wang, Zhi Qiang; Zhang, Dong Sheng; Luo, Hui; Zhou, Zhi Wei; Wang, Feng Hua; Li, Yu Hong; Jiang, Wen Qi; Xu, Rui‐Hua

doi:10.1007/s13277-010-0145-2

Cited by 35 publications

(37 citation statements)

References 23 publications

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“…In our previous study, we showed that as the age increased there was a steady increasing in the proportion of male and steady decreasing of female [24]. Similarly, we presently also found a steady increasing in the ratio between male and female as the age increased.…”

Section: Discussionsupporting

confidence: 71%

Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China

et al. 2013

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BackgroundAccording to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown.MethodsWe examined the archive of 1000 patients with gastric adenocarcinomas who received radical gastrectomy in our center and assessed the effect of the Lauren classification on survival in a multivariate approach. Moreover we compared the variation of clinical features between the diffuse-type and intestinal-type and explored the contributing factors for the prognostic difference.ResultsThere were 805 resectable patients for the final analysis. Diffuse-type comprised of 48.7% in the gastric carcinoma in our group and showed poorer prognosis than intestinal-type (P=0.013). Multivariate analysis revealed that independent prognostic factors for gastric carcinoma patients were T stage (P<0.001), N stage (P<0.001) tumor size (P<0.001) and Lauren classification (P=0.003). For the clinical features, diffuse-type was significantly associated with younger age (p<0.001), female preponderance (p <0.001), distal location (P<0.001), advanced pT (p < 0.001), advanced pN (p < 0.001) and advanced TNM stage (p = 0.027).ConclusionsDiffuse type adenocarcinoma carries a worse prognosis that may be partially explained by the tendency of this subtype to present at more advanced T and N stage. However, Lauren classification has prognostic significance that is independent of T and N stage as well as other prognostic variables based on the multivariate cox analysis.

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Section: Discussionsupporting

confidence: 71%

Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China

et al. 2013

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“…Other authors have obtained different results, so that gastric cancer in younger patients has been commonly considered more aggressive and as having a poorer prognosis [5–7, 22]. Conversely, other researchers have reported better long-term survival outcomes in younger age groups [7, 16, 17, 23]. A recent investigation conducted on 2,757 patients younger than 45 showed that younger age was associated with improved survival after stratification by cancer stage at presentation, suggesting that a stage-dependent rather than age-dependent approach should be taken in younger patients with gastric cancer [5].…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer in the Young: Is It a Different Clinical Entity? A Retrospective Cohort Study

Pisanu

Podda

Cois

et al. 2014

Gastroenterology Research and Practice

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Background. The rate of gastric cancer in young patients has increased over the past few decades. The aim of this study was to search for independent risk factors related to patients of younger age. Methods. From January 1996 to December 2012, a series of 179 consecutive patients were admitted to our surgical department because of a gastric cancer. We carried out a retrospective cohort study in 20 patients younger than 50 and in 112 patients aged 50 and older treated by curative gastrectomy. The comparison involved the evaluation of patient and tumor characteristics. Results. Younger patients had significantly less comorbidities and a more favorable American Society of Anesthesiology score; they had significantly less preoperative weight loss and a significantly longer duration of symptoms; Helicobacter pylori infection and diffuse histological type were significantly associated with younger age. There was no statistically significant difference regarding overall and cancer-related 5-year survival; advanced cancer stage and diffuse histological type were the independent negative prognostic factors influencing cancer-related survival. Conclusions. We do not have sufficient evidence to consider gastric cancer in younger patients as a different clinical entity. Further studies are needed to understand carcinogenesis in younger patients and to improve gastric cancer classification.

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“…Qiu et al . [6] reported that the MFSR increased with an increase in age. The total MFSR was 2.15:1.…”

Section: Introductionmentioning

confidence: 99%

Age trend of the male to female sex ratio in surgical gastric cancer patients at a single institution

He²,

Guo

2014

World J Surg Onc

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BackgroundIn previous reports concerning the association between sex disparity and age, gastric cancer (GC) patients were simply divided into younger and older groups by age. We analyzed the age trend of the male to female sex ratio (MFSR) in GC based on patient sequential age in order to observe the changing process of MFSR with age.MethodsOne thousand seven hundred fifty-one surgical gastric adenocarcinoma patients aged 26 to 85 years were investigated between January 1996 and December 2010. The patients were grouped by age intervals of 5 years. The Cochran-Armitage trend test was used to determine how the MFSR changed with age.ResultsThe median age of the 1,751 patients with GC was 60 years (26 to 85 years). There were 1,334 male and 417 female patients (MFSR was 3.20). Cochran-Armitage trend test analysis showed that total MFSR increased significantly with age (Z = 5.964, P < 0.0001). Further studies on age groups of 26 to 60 years and 61 to 85 years were conducted. The trend test showed that MFSR increased significantly with age from 26 to 60 years (Z = 7.433, P < 0.0001). However, MFSR did not increase in ages 61 to 85 years (Z = -0.607, P = 0.544).ConclusionsMFSR in GC presented an increasing trend until 60 years of age. The male GC patients showed an increasing tendency, and female GC patients showed a decreasing tendency with age. This trend reached a plateau phase after 60 years of age.

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Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China

Cited by 35 publications

References 23 publications

Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China

Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China

Gastric Cancer in the Young: Is It a Different Clinical Entity? A Retrospective Cohort Study

Age trend of the male to female sex ratio in surgical gastric cancer patients at a single institution

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