Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor

Park, Cheol Keun; Kim, Hyun Soo

doi:10.21873/anticanres.12879

Cited by 27 publications

(32 citation statements)

References 29 publications

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“…Overin metastatik tümörleri overyan malignensilerin %5-30'unu oluşturmaktadır (3). Metastatik müsinöz karsi- (1,2,(4)(5)(6)(7)(8)(9)(10)(11)(12). Ancak bu belirteçlerden CK7 ve CK20'nin temel olarak olguların çoğunda tanıya yardımcı olduğu bildirilmektedir.…”

Section: Discussionunclassified

“…İmmünohistokimyasal olarak olgulara uygulanan CK7 ve CK20 ile değerlendirme yapıldığında; primer tümörlerin tamamında CK7 (+) / CK20 (-) idi. CK7 (+) / CK20 (-) olan olgulardan iki tanesi daha önce tanı almış meme karsinomu, bir tanesi de endometrial mikst karsinom GIRIŞ Pankreas, apendiks, meme, kolon, mide ve jinekolojik organlar başta olmak üzere pek çok organın overe metastaz yaptığı bilinmektedir (1,2). Çoğu zaman primer tümör önceden bilinse de bazen hasta ilk bulgu olarak pelvik kitle ile başvurabilmektedir.…”

Section: Bulgularunclassified

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Algorithmic Approach to Primary and Metastatic Mucinous Ovarian Tumors

Bağır¹,

Acikalin²,

Güleç³

et al. 2019

Akd Med J

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Bu çalışmanın amacı overin primer ve metastatik müsinöz tümörlerinde ayırıcı tanıda histopatolojik özelliklere ek olarak immünohistokimyasal bulgular, tümör boyutu ve lateralitenin primer-metastaz ayırımındaki tanısal değerini araştırmaktır. Gereç ve Yöntemler: Hastanemizde 2001-2012 yılları arasında tanı alan 222 müsinöz over tümörü olguları patoloji arşivinden retrospektif olarak tarandı. Olgular yaş, lateralizasyon, tümör boyutu ve immünohistokimyasal olarak değerlendirildi. Bulgular: Çalışmaya dahil edilen 222 olgunun 195'i primer müsinöz over tümörü, 27'si metastatik müsinöz tümör tanısı almış idi. Primer olguların kendi içinde dağılımları sırası ile kistadenomlar 135/195, müsinöz karsinomlar 31/195 ve borderline tümörler 29/195 idi. Olguların yaş ortalaması 48,7 (14y-72y) idi. Lateraliteye bakıldığında borderline tümörlerin (29/29) ve müsinöz karsinomların (27/31) tek overde görülme oranları daha yüksek iken metastatik tümörlerde bu oran daha düşük idi (11/27). Tümör boyutları değerlendirildiğinde primer tümörlerde boyutun daha yüksek olduğu metastatik lezyonlarda tümör boyutunun daha düşük olduğu tespit edildi. Sonuç: Müsinöz tümörler, over tümörleri içerisinde metastaz ve primer ayırımının yapılması gereken önemli bir gruptur. Metastatik tümörlerin büyük bir kısmı primer over tümörünü taklit ederler ancak metastaz-primer ayırımında tümör boyutu ve lateralitenin önemli bir veri olduğunu bunun yanında immünohistokimyanın da tanısal doğruluğu artırmada yararlı olacağını düşünmekteyiz.

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Section: Discussionunclassified

Section: Bulgularunclassified

Algorithmic Approach to Primary and Metastatic Mucinous Ovarian Tumors

Bağır¹,

Acikalin²,

Güleç³

et al. 2019

Akd Med J

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“…The 4 µm-thick, FFPE slices were de-paraffinized and rehydrated using a xylene and alcohol solution. Immunostaining was performed using automated instruments (Ventana Benchmark XT (Ventana Medical Systems) and or Dako Omnis (Dako, Carpinteria, CA, USA)) [1,[18][19][20][21][22][23][24][25][26]. After antigen retrieval, the slices were incubated with primary antibodies including pan-cytokeratin (pan-CK; 1:600, clone AE1/AE3, Dako), CK7 (Dako, 1:100, clone OV-TL 12/30, Dako), CK20 (1:100, clone Ks20.8, Dako), caudal type homeobox 2 (CDX2; 1:400, clone EPR2764Y, Cell Marque, Rocklin, CA, USA), paired box 8 (PAX8; 1:50, polyclonal, Cell Marque), estrogen receptor (ER; 1:150, clone 6F11, Novocastra, Leica Biosystems, Newcastle Upon Tyne, UK), progesterone receptor (PR; 1:100, clone 16, Novocastra), p53 (1:300, clone DO-7, Novocastra), p16 (prediluted, clone E6H4, Ventana Medical Systems), p63 (1:50, clone 4A4, Dako), and GATA-binding protein 3 (GATA3; 1:150, clone L50-823, Cell Marque).…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Metastases to female reproductive organs often pose diagnostic challenges for both pathologists and clinicians, and tend to be overlooked in the differential diagnoses of other gynecological malignancies. In the rare event of metastases to the female genital tract, the ovaries are most often affected [1]. Malignancies that secondarily involve the uterus usually extend directly from adjacent pelvic organs including the rectum, urinary bladder, and peritoneum; alternatively, they may develop consequent to widespread peritoneal dissemination.…”

Section: Introductionmentioning

confidence: 99%

Endometrium-Limited Metastasis of Extragenital Malignancies: A Challenge in the Diagnosis of Endometrial Curettage Specimens

Choi

Joo

et al. 2020

Diagnostics

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Malignancies of extragenital origin very rarely metastasize to the uterine body. Endometrium-limited metastases may pose diagnostic challenges in endometrial curettage specimens as they may be misdiagnosed as primary endometrial tumors. We investigated the clinicopathological characteristics of seven cases with endometrial-limited metastases from carcinomas of the nasopharynx (n = 1), breast (n = 2), colon (n = 2), stomach (n = 1), and appendix (n = 1). The patients’ ages ranged from 36 to 71 (mean: 55.4) years. None of the patients had a remarkable gynecological history, and the presenting sign in all cases was abnormal uterine bleeding. Although myometrial involvement was absent, multiple metastases were already present in extrauterine locations such as the lung, liver, bone, abdominopelvic peritoneum, and omentum. All patients underwent ultrasonographic examination prior to endometrial curettage. The histologies of the endometrial metastases identified from the curettage specimens were identical to those of the corresponding primary tumors. Ancillary tests including immunostaining and Epstein–Barr virus-encoded RNA in situ hybridization confirmed the extragenital origin. Endometrium-limited metastases from extragenital malignancies are extremely rare. They present with abnormal vaginal bleeding and mimic endometrial carcinomas of endometrioid or poorly differentiated types. Since their clinical presentations and histological features are similar to those of primary endometrial tumors, pathologists should consider the possibility of metastases while evaluating endometrial curettage specimens obtained from patients with a history of extragenital malignancies.

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“…Systems)] according to the manufacturer's recommendations (9,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Antigen retrieval was performed using Cell Conditioning Solution (CC1, Ventana Medical Systems).…”

Section: Immunohistochemical Staining Immunostaining Was Performed Umentioning

confidence: 99%

Targeted Sequencing of Tubo-ovarian and Peritoneal High-grade Serous Carcinoma With Wild-type p53 Immunostaining Pattern

Kim

Woo

et al. 2019

In Vivo

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Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor

Cited by 27 publications

References 29 publications

Algorithmic Approach to Primary and Metastatic Mucinous Ovarian Tumors

Algorithmic Approach to Primary and Metastatic Mucinous Ovarian Tumors

Endometrium-Limited Metastasis of Extragenital Malignancies: A Challenge in the Diagnosis of Endometrial Curettage Specimens

Targeted Sequencing of Tubo-ovarian and Peritoneal High-grade Serous Carcinoma With Wild-type p53 Immunostaining Pattern

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