Cloning, characterization and tissue expression of disk abalone (Haliotis discus discus) catalase

A catalase from the freshwater mussel Cristaria plicata with cloning, identification and protein characterization

“…For instance, the Asp62 (D) residue of catalytic site motif in vertebrate was replaced by Asn62(N) residue in cpCAT, this case were also found in H. discus and C. farreri [3,15]. Two glycosylation sites (N145 and N436) were found in cpCAT just the same as C. farreri [15], but only one was found in D. rerio and M.musculus [17,18].…”

“…However, excessive production or accumulation of ROS in the cells creates a state called "oxidative stress", which can cause cellular damage by peroxidizing cellular proteins, nucleic acids and lipids; deactivation of enzymes; deregulation of redoxesensitive reactions and signaling pathways [3]. In order to protect against oxidative stress, aerobic cells regulate excessive ROS by a group of antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (Gpx), peroxiredoxins (Prx), and non-enzymatic antioxidant molecules.…”

Expression of heat shock protein 90 genes during early development and infection in Megalobrama amblycephala and evidence for adaptive evolution in teleost

“…The results suggested that both Hsp90 genes act as positive acute phase proteins during bacterial infection in M. amblycephala. Although the exact mechanisms underlying Hsp90 induction and the role of Hsp90 during bacterial infection have not been fully elucidated, it is generally assumed that the up-regulated expression of Hsp genes were protective against bacterial infection (Ekanayake et al, 2008;Essig and Nosek, 1997;Gao et al, 2008;Ramaglia et al, 2004). Therefore, the rapid and strong response of M. amblycephala Hsp90 genes after A. hydrophila infection might be associated with their participation in immune processes.…”

Cloning and expression of a heat shock protein (HSP) 90 gene in the haemocytes of Crassostrea hongkongensis under osmotic stress and bacterial challenge

“…In invertebrates, when an organism is infected with bacteria, phagocytosis is usually activated in the host. The generation of reactive oxygen species (ROS), always associated with phagocytosis, is an effective strategy for a host cell to fight a pathogen such as bacterial invasion [31]. However, ROS could also lead to protein denaturation or proteotoxicity in the host cell itself.…”