Cloning, distribution and effects of season and nutritional status on the expression of neuropeptide Y (NPY), cocaine and amphetamine regulated transcript (CART) and cholecystokinin (CCK) in winter flounder (Pseudopleuronectes americanus)

MacDonald, Erin; Volkoff, Hélène

doi:10.1016/j.yhbeh.2009.03.002

Cited by 79 publications

(53 citation statements)

References 68 publications

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“…In the present study, CART mRNA expression levels did not change in response to food intake in Atlantic halibut larvae. This aligns with studies in other pleuronectiformes species, such as adult winter flounder (MacDonald and Volkoff, 2009a). CART may therefore play a minor role in the control of appetite and feeding for these species, and it may have other physiological functions.…”

Section: Discussionsupporting

confidence: 87%

“…NPY, PYY and POMC-C mRNA levels was not significantly Kurokawa and Suzuki (2002). c MacDonald and Volkoff (2009a). different between the developmental stages analysed.…”

Section: Ontogenymentioning

confidence: 89%

“…The role of these neuropeptides in appetite control in larval fish is largely unexplored. The NPY gene is wellconserved in vertebrates, and in mammals the peptide provides one of the strongest orexigenic signals (Cerda-Reverter et al, 2003;Larhammar, 1996;Volkoff et al, 2009), while in teleosts the importance for appetite control seems to be species-specific (Aldegunde and Mancebo, 2006;Kehoe and Volkoff, 2007;López-Patiño et al, 1999;MacDonald and Volkoff, 2009a;Narnaware and Peter, 2001;Narnaware et al, 2000;Silverstein et al, 1998;Silverstein and Plisetskaya, 2000;Valen et al, 2011). In Atlantic cod (Gadus morhua), it has been shown that mRNA expression of NPY is modulated throughout development and by diet (Kortner et al, 2011a;Kortner et al, 2011b).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroendocrine control of appetite in Atlantic halibut (Hippoglossus hippoglossus): Changes during metamorphosis and effects of feeding

Gomes

Jordal

Olsen

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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Section: Discussionsupporting

confidence: 87%

“…NPY, PYY and POMC-C mRNA levels was not significantly Kurokawa and Suzuki (2002). c MacDonald and Volkoff (2009a). different between the developmental stages analysed.…”

Section: Ontogenymentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroendocrine control of appetite in Atlantic halibut (Hippoglossus hippoglossus): Changes during metamorphosis and effects of feeding

Gomes

Jordal

Olsen

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Indeed, exogenous factors such as temperature may result in a reduction in food intake and modify the digestive physiology in several fi sh species. In the winter fl ounder, hypothalamic NPY expression is not affected by fasting of two or even four weeks in the winter months, but these same starvation periods increase NPY levels in the summer (MacDonald and Volkoff 2009a). Here, we demonstrate that in Brazilian fl ounder, NPY mRNA levels increased after two weeks of fasting in the summer, as demonstrated in the winter skate (MacDonald and Volkoff 2009b).…”

Section: Discussionsupporting

confidence: 66%

“…NPY expression was detected in several peripheral tissues as described by MacDonald and Volkoff (2009a). Possible differences in NPY expression level among the peripheral tissues of Brazilian fl ounder might be the result of a differential regulation of NPY expression.…”

Section: Discussionmentioning

confidence: 90%

Identification, tissue distribution and evaluation of brain neuropeptide Y gene expression in the Brazilian flounder Paralichthys orbignyanus

et al. 2010

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Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in vertebrates, mammals and fish. However, the present knowledge about feeding behaviour in fish is still limited and based on studies in a few species. The Brazilian flounder Paralichthys orbignyanus is being considered for aquaculture, and it is important to understand the mechanisms regulating feeding in order to improve its performance in captivity. The objectives of this study were to clone NPY cDNA, evaluate the mRNA levels in different tissues of flounder, and also evaluate brain NPY expression to associate food intake with NPY expression levels. A 597 bp NPY cDNA was cloned from Brazilian flounder brain. NPY expression was detected in all the peripheral tissues analysed. No significant differences were observed in brain NPY gene expression over 24 h after food intake at a temperature of 15 +or- 3 degrees C. No correlation was observed among plasma glucose, total protein, cholesterol, triglycerides and NPY expression levels during this 24 h period. On the other hand, mRNA levels were increased after two weeks of fasting at elevated temperatures. Our results suggest that NPY mRNA levels in Brazilian flounder are affected by temperature.

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Immunohistochemical mapping of neuropeptide Y in the tree shrew brain

Shu

Luo

et al. 2014

J of Comparative Neurology

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Day-active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY-immunoreactive (-ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon of tree shrews. Most NPY-ir cells were multipolar or bipolar in shape with triangular, fusiform, and/or globular perikarya. The densest cluster of NPY-ir cells were found in the mitral cell layer of the main olfactory bulb (MOB), arcuate nucleus of the hypothalamus, and pretectal nucleus of the thalamus. The MOB presented a unique pattern of NPY immunoreactivity. Laminar distribution of NPY-ir cells was observed in the MOB, neocortex, and hippocampus. Compared to rats, the tree shrews exhibited a particularly robust and widespread distribution of NPY-ir cells in the MOB, bed nucleus of the stria terminalis, and amygdala as well as the ventral lateral geniculate nucleus and pretectal nucleus of the thalamus. By contrast, a low density of neurons were scattered in the striatum, neocortex, polymorph cell layer of the dentate gyrus, superior colliculus, inferior colliculus, and dorsal tegmental nucleus. These findings provide the first detailed mapping of NPY immunoreactivity in the tree shrew brain and demonstrate species differences in the distribution of this neuropeptide, providing an anatomical basis for the participation of the NPY system in the regulation of numerous physiological and behavioral processes.

show abstract

Cloning, distribution and effects of season and nutritional status on the expression of neuropeptide Y (NPY), cocaine and amphetamine regulated transcript (CART) and cholecystokinin (CCK) in winter flounder (Pseudopleuronectes americanus)

Cited by 79 publications

References 68 publications

Neuroendocrine control of appetite in Atlantic halibut (Hippoglossus hippoglossus): Changes during metamorphosis and effects of feeding

Neuroendocrine control of appetite in Atlantic halibut (Hippoglossus hippoglossus): Changes during metamorphosis and effects of feeding

Identification, tissue distribution and evaluation of brain neuropeptide Y gene expression in the Brazilian flounder Paralichthys orbignyanus

Immunohistochemical mapping of neuropeptide Y in the tree shrew brain

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