Cluster analysis of uric acid exchange parameters in female rats

Abstract

Background. Uric acid is traditionally considered as the final product of human and primate DNA/RNA degradation, devoid of useful physiological activity. However, there is an opinion that the uric acid molecule, by analogy with methylxanthines (caffeine, theophylin, theobromine) has physiological activity. The acquired experience allows us to offer a topic for future research: "Neurotropic and immunotropic activity of endogenous uric acid". Working hypothesis. Uric acid, interacting with A1 and A2a adenosine receptors as well as phosphodiesterase and Na,K-ATPase of neurons, modulates the activity of nerve centers, which in turn modulate immunocytes. Perhaps the direct effect of uric acid on immunocytes, since the existence of theophylline-resistant and theophylline-sensitive subpopulations of Tlymphocytes has long been known. The proposed article is the first swallow of the announced project. Material and Methods. Experiment was performed on 58 healthy female Wistar rats 220-300 g. Among them 10 animals remained intact, using tap water from drinking ad libitum.The rats of others groups for 6 days administered through the tube various fluids at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course the plasma

Features of immune status in different states of uric acid metabolism in female rats

“…Because analysis of variance revealed that the η 2 criterion for uricemia was significantly greater than that for uricosuria (0,95 versus 0,25) [11], uricemia was chosen as a main parameter in determining the characteristics of immune status in various uric acid metabolism states.…”

“…Previously, we found a wide range of uric acid metabolism parameters grouped into four clusters [11] and functional relationships of uricemia and uricosuria with the parameters of immunity in female rats analyzed [12]. It was found by canonical correlation analysis that the causal root receives a factor load from uricosuria twice that from uricemia.…”

Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction

“…Previously, continuing experimental studies [6][7][8]10], by screening correlation links between uricemia and uricosuria, on the one hand, and immunity and microbiota parameters, on the other, registered in each of 44 patients with chronic pyelonephritis and cholecystitis in remission twice (before and after ten days of balneotherapy), we found that raw uricemia determines by 28% nine parameters of immunity as well as bacteriuria and content in E. coli feces. Uricemia, normalized by sex and age, determines by 25% another constellation of immunity parameters as well as content in E. coli feces with impaired enzymatic activity and Klebsiela&Proteus.…”

Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction

“…In line with the concept we have previously adopted [7] that Uric acid is structural homolog of Caffeine, which in turn is a structural homolog of Adenosine [17,28], of particular interest are the data that peripheral T-cell depletion due to inhibition of T-cell expansion by extracellular Adenosine mediated signaling through A2A receptors [11]. It is shown that Caffeine increases cell death and migration in Cytotoxic but not Helper T-Lymphocytes as well as B-Lymphocytes in familiar but not naїve individuals following moderate intensity exercise [18].…”

“…Previously, we found a wide range of uric acid exchange parameters grouped into four clusters [7] and functional relationships of uricemia and uricosuria with the parameters of immunity in healthy rats analyzed [8][9][10].…”