Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

Kong, Xianglei; Ma, Xiaojing; Zhang, Chengyin; Xu, Dongmei

doi:10.1016/j.cdtm.2018.02.005

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Consequently, total risk of CVD is the sum of respective risks arising from the incidence of major CRFs. [10][11][12][13][14] The estimated risk of a CVD increases with the emergence of an additional CRF. 15 Age is also frequently allocated into the same category.…”

Section: Introductionmentioning

confidence: 99%

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

Macek¹,

Žák²,

Terek-Derszniak³

et al. 2020

CIA

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Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide; with age acknowledged as an independent cardiovascular risk factor (CRF) in adults. Appreciating the association between age and classic CRFs is believed to boost all potential benefits of prevention. Purpose: Assessment of the prevalence of single and clustered CRFs and their association with age. Patients and Methods: The survey involved 4735 people (33.6% men) who were PONS project attendees aged 45-64. The study protocol comprised the Health Status Questionnaire, general medical examination, anthropometric measurements, and blood and urine sampling. The prevalence of single and clustered CRFs (hypertension, dyslipidemia, diabetes mellitus, and obesity) in the incrementally split age groups was calculated. The incidence rate of CRFs, against their absence, was determined by Poisson regression models with robust standard errors. Results: The prevalence of CRFs was established in 90% of the respondents. Except dyslipidemia and ≥1 CRFs, prevalence of risk factors increased with age, although this trend was the weakest in men. In the total group, and in women, prevalence of dyslipidemia and ≥1 CRFs was unrelated to age, whereas in men, it was on the rise in the younger age groups. The incidence rate of CRFs was strongly related to age, and, with the exception of dyslipidemia, was higher in the older age groups. Conclusion: Cardiovascular risk factors are common in the adult population, while their prevalence and clustering are more prevalent in seniors. Apart from dyslipidemia, the risk of CRFs is appreciably age-related, and higher in seniors.

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Section: Introductionmentioning

confidence: 99%

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

Macek¹,

Žák²,

Terek-Derszniak³

et al. 2020

CIA

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show abstract

“…Several studies have reported prevalence of clusters of CVD risk factors in the general population. [19][20][21] Few studies have identified cluster types based on sleep pattern 22 , behavioural characteristics 23 , and cardiometabolic health 24 in CMVDs, yet little is known about clusters of CVDs risk factors among CMVDs; though the prevalence of these risk factors have been well described in this group. 25,26 Evidence-based practices have shown that chronic diseases such as hypertension, diabetes, and hyperlipidemia are better treated together since they often occur in clusters.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clusters of modifiable cardiovascular disease risk factors among intra- city commercial motor vehicle drivers in a Nigerian metropolitan city

Showande

Odukoya

2020

gmj

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Background: Commercial motor vehicle drivers (CMVDs) have worst health profiles among different occupations, yet the presence of clusters of cardiovascular disease (CVD) risk factors in this group have not been described in a resource-limited setting.Objectives: The prevalence of CVD risk factors and the clusters among CMVDs was evaluated.Design: A cross-sectional descriptive study.Setting: Four motor parks in three local government areas of Ibadan city, Nigeria.Participants: Consented and conveniently sampled 152 intra-city CMVDs aged ≥ 18 years. Main outcome measures: Prevalence of CVD risk factors (hypertension, diabetes, high triglyceride, low HDLc, high waist-hip ratio, central obesity, physical inactivity, smoking, alcohol, and overweight/obesity) and their clusters were determined.Results: All participants were male from 20 – 77 years old. Most of the CMVDs were physically inactive (80, 52.6%), take alcohol (78, 51.3%), and few smokes (35, 12.4%). The prevalence of hypertension, diabetes, hypertriglyceridemia,obesity, and central obesity were 36.2%, 5.9%, 23.7%, 4.6%, and 5.3%, respectively. Four clusters of CVD risk factors in the CMVDs with the prevalence of 36.2%. 33.5%, 17.1% and 13.2% were identified with significant differences (p<0.05) in the risk factors.Conclusion: The prevalence of diabetes, obesity, central obesity, and smoking was low while the prevalence of hypertension and hypertriglyceridemia was moderate among the CMVDs, but the prevalence of alcohol intake and physical inactivity were high. Four distinct clusters of CVD risk factors were observed among the drivers.Keywords: Cardiovascular diseases, Risk factors, Motor vehicles, Commercial vehicle drivers, Nigeria.Funding: The study was self-funded.

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“… 39 , 40 The clustering of CVD risk factors has been significantly correlated with arterial stiffness. 41 Jeanclos et al 42 also suggested that telomere shortening was associated with hypertension, endothelial dysfunction, atherosclerosis, and cardiovascular mortality. In patients with CKD, due to oxidative stress and inflammation, vascular calcification can be aggravated, which increases the risk of CVD, a phenomenon that can also be reflected by the shortened telomere length.…”

Section: Discussionmentioning

confidence: 99%

Telomere shortening in patients on long‐term hemodialysis

Wang

Chen

Feng

et al. 2021

Chronic Diseases and Translational Medicine

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Background Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification. Methods A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis. Results The leukocyte telomere length was negatively associated with age (rho = −0.306, P ＜0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52–74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01). Conclusion This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.

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Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

Cited by 4 publications

References 28 publications

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

Prevalence and clusters of modifiable cardiovascular disease risk factors among intra- city commercial motor vehicle drivers in a Nigerian metropolitan city

Telomere shortening in patients on long‐term hemodialysis

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