We examine a silicon-germanium heterojunction bipolar transistor (HBT) for cryogenic pre-amplification of a single electron transistor (SET). The SET current modulates the base current of the HBT directly. The HBT-SET circuit is immersed in liquid helium, and its frequency response from low frequency to several MHz is measured. The current gain and the noise spectrum with the HBT result in a signal-to-noise-ratio (SNR) that is a factor of 10−100 larger than without the HBT at lower frequencies. The transition frequency defined by SNR = 1 has been extended by as much as a factor of 10 compared to without the HBT amplification. The power dissipated by the HBT cryogenic pre-amplifier is approximately 5 nW to 5 μW for the investigated range of operation. The circuit is also operated in a single electron charge read-out configuration in the time-domain as a proof-of-principle demonstration of the amplification approach for single spin read-out. Donor spin qubits have recently received increased interest because of the demonstration of high fidelity coherent control of phosphorus donors using a local electron spin resonance technique. 1,2 This approach is of interest both for quantum information 3-5 as well as representing a new experimental platform to investigate the behavior of single impurities in semiconductors using electron and nuclear magnetic resonance. Single-shot readout 6-8 of the spin polarization is an important component of the measurement. It may be accomplished using a wide-band measurement of the single electron transistor 9 (SET) conductance, which is sensitive to the ionization condition of any nearby donors. 10,11 The technique relies on alignment of the neighboring SET chemical potential between discrete Zeeman energy levels. The donor spinup electron ionizes into the SET, leading to a detectable transient change in the local electrostatic potential, while a SET electron waits to reload into the donor as a spindown. The temporary ionization of the donor changes the conductance of the SET, which is measured as a current pulse corresponding to a spin-up electron or no pulse if the electron was spin-down.Read-out fidelity can be no better than what the signal-to-noise-ratio (SNR) provides for a particular bandwidth, although other factors can introduce errors that degrade the fidelity, such as rapid tunneling events that are faster than the bandwidth of the read-out. The donor read-out technique is performed at cryogenic temperatures less than 4 K, which is typically necessary to observe the spin read-out of the donor state at reasonably low magnetic fields. The SET current is subsequently amplified at room-temperature (RT) using one or several amplification stages, typically including a transconductance amplifier. The line capacitance between the transconductance amplifier and the SET typically sets the limits of performance of the circuit. Increased readout bandwidth can improve fidelity, for example, by detecting faster tunnel events, however, the increased bandwidth reduces SNR. The SNR can be i...