CMOS microelectrode array for extracellular stimulation and recording of electrogenic cells

Heer, F. J. de; Franks, Wendy; McKay, I.; Taschini, S.; Hierlemann, Andreas; Baltes, H.

doi:10.1109/iscas.2004.1328938

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…2D potential distribution was generated with the use of capacitively coupled active electric pixels, to control the positions of cultured cells by dielectrophoresis [ 80 – 82 ]. On the other hand, intelligent multielectrode array devices can be realized by exposing the sensing electrode to detect the extracellular potentials of neural cells [ 83 – 85 ].…”

Section: Cell Detectionmentioning

confidence: 99%

CMOS Cell Sensors for Point-of-Care Diagnostics

Adıgüzel

Külah

2012

Sensors

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The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

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Section: Cell Detectionmentioning

confidence: 99%

CMOS Cell Sensors for Point-of-Care Diagnostics

Adıgüzel

Külah

2012

Sensors

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“…However, we cannot apply a voltage or inject current using the passive configuration. A sensing electrode connected via switching circuitry is required to realize “active” measurement schemes; that is, to apply voltage or inject current from or to the sensing electrode [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. In the active sensing approach, we can achieve both capacitive coupling (in which the sensing electrode is covered with a dielectric insulation layer) and conductive coupling (with exposed sensing electrodes).…”

Section: Application Targets For Multifunctional On-chip Image Senmentioning

confidence: 99%

“…Alternatively, an intelligent multielectrode array (MEA) device can be realized by exposing the sensing electrode to detect the extracellular potentials of neural cells [ 61 , 62 , 63 , 64 , 65 ]. Conventional high-density electrochemical measurements are possible.…”

Section: Application Targets For Multifunctional On-chip Image Senmentioning

confidence: 99%

“…As another possible application, the sensor can be used as an in vitro neural observation device. As reported by many groups [ 61 , 62 , 63 , 64 , 65 ], on-chip electric imaging is a promising technology for in vitro neural imaging technology. Using the present sensor, we can capture real-time optical and electric images of neural activity.…”

Section: Optical + Passive Electric Sensing Cmos Image Sensormentioning

confidence: 99%

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Optical and Electric Multifunctional CMOS Image Sensors for On-Chip Biosensing Applications

et al. 2010

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In this review, the concept, design, performance, and a functional demonstration of multifunctional complementary metal-oxide-semiconductor (CMOS) image sensors dedicated to on-chip biosensing applications are described. We developed a sensor architecture that allows flexible configuration of a sensing pixel array consisting of optical and electric sensing pixels, and designed multifunctional CMOS image sensors that can sense light intensity and electric potential or apply a voltage to an on-chip measurement target. We describe the sensors’ architecture on the basis of the type of electric measurement or imaging functionalities.

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