CMP-aminoéthylphosphonate: intermédiaire de la biosynthèse des phosphonolipides dans le foie de rat

Transcriptomic-Guided Phosphonate Utilization Analysis Unveils Evidence of Clathrin-Mediated Endocytosis and Phospholipid Synthesis in the Model Diatom, Phaeodactylum tricornutum

“…It was reported that 2-AEP first reacts with CTP to form CMP-2-AEP, which is then transferred to diglyceride to form the glycerophospholipid ( 8 ). The process of DAG-2-AEP synthesis has been described in animal tissues ( 62 , 63 ). Though there is no report on the presence of DAG-2-AEP in algae cells, the biosynthesis pathway can be depicted based on the transcriptomic data obtained in this study.…”

Phosphonates as analogues of natural phosphates

“…Both approaches are in common use and the reader would be well advised to be familiar with both.] The use of this approach is also claimed83 for the preparation of the corresponding isosteric phosphonic acids related to D-xylose 5-phosphate (16), o-lyxose 5-phosphate (17), D-arabinose 5-phosphate (18), 2-deoxy-D-ribose 5-phosphate (19), D-glucose 6-phosphate (20), and o-mannose 6-phosphate (21), although complete experimental details for each are not provided in the patent. More recently this same approach has been described by Adams et al87 for the preparation of 20.…”

“…Still later work demonstrated that 2-aminoethylphosphonic acid could be incorporated into lipids in rat liver involving initial generation of CMP-aminoethylphosphonate. 16•17 Phosphonatase activity at a low level may be present in numerous organisms. The topic of natural phosphonic acids has been treated in detail in other places and will not be a major consideration here.…”

Comparative transcriptomics unveil distinctive metabolic pathway of phosphonate utilization by diatom Phaeodactylum tricornutum

“…Study shows that 2-AEP firstly reacts with CTP to form CMP-2-AEP, which then is transferred to diglyceride to form the glycerophospholipid [5]. The process of DAG-2-AEP synthesis has been described in animal tissues [65, 66]. Though there is no report about the presence of DAG-2-AEP in algae cells, we are able to depict the biosynthesis pathway based on the transcriptomic data obtained in this study.…”