CNS effects of peptides: A cross-listing of peptides and their central actions published in the journal Peptides, 1986–1993

Ahmed, Bilal; Kastin, Abba J.; Banks, William A.; Zadina, James E.

doi:10.1016/0196-9781(94)90078-7

Cited by 10 publications

(2 citation statements)

References 404 publications

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“…Over the last decades, numerous reviews have appeared on the behavioral and physiological aspects of β-END [ 35 – 63 ]. From these, it becomes clear that β-END is involved in a wide variety of functions ranging from the cellular to the behavioral level.…”

Section: Introductionmentioning

confidence: 99%

The effects of Beta-Endorphin: state change modification

Veening

Barendregt

2015

Fluids Barriers CNS

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Beta-endorphin (β-END) is an opioid neuropeptide which has an important role in the development of hypotheses concerning the non-synaptic or paracrine communication of brain messages. This kind of communication between neurons has been designated volume transmission (VT) to differentiate it clearly from synaptic communication. VT occurs over short as well as long distances via the extracellular space in the brain, as well as via the cerebrospinal fluid (CSF) flowing through the ventricular spaces inside the brain and the arachnoid space surrounding the central nervous system (CNS). To understand how β-END can have specific behavioral effects, we use the notion behavioral state, inspired by the concept of machine state, coming from Turing (Proc London Math Soc, Series 2,42:230-265, 1937). In section 1.4 the sequential organization of male rat behavior is explained showing that an animal is not free to switch into another state at any given moment. Funneling-constraints restrict the number of possible behavioral transitions in specific phases while at other moments in the sequence the transition to other behavioral states is almost completely open. The effects of β-END on behaviors like food intake and sexual behavior, and the mechanisms involved in reward, meditation and pain control are discussed in detail. The effects on the sequential organization of behavior and on state transitions dominate the description of these effects.

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Section: Introductionmentioning

confidence: 99%

The effects of Beta-Endorphin: state change modification

Veening

Barendregt

2015

Fluids Barriers CNS

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“…The biological function of this group of substances has been examined in detail and described in a number of reviews and monographs (e.g. [1–3]). At the same time, there are many biologically active peptides that do not correspond to the above mentioned features of `classical' peptide bioregulators.…”

Section: Introductionmentioning

confidence: 99%

A novel system of peptidergic regulation

1998

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Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). According to that concept, the proteolytic degradation of tissue proteins carried out by a specific and regulated system of tissue-specific enzymes and protein substrates gives rise to a large group of peptides, which we define as tissue-specific peptide pool. As a result, functional proteins provide their proteolytically derived fragments for maintaining tissue homeostasis.z 1998 Federation of European Biochemical Societies.

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Biology of Peptides

Sewald

Jakubke

2009

Peptides: Chemistry and Biology

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CNS effects of peptides: A cross-listing of peptides and their central actions published in the journal Peptides, 1986–1993

Cited by 10 publications

References 404 publications

The effects of Beta-Endorphin: state change modification

The effects of Beta-Endorphin: state change modification

A novel system of peptidergic regulation

Biology of Peptides

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