Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration

Ding, Yifan; Wang, Huan; Wang, Yunyun; Li, Long; Ding, Jiahui; Yuan, Caiyan; Xu, Tao; Xu, Haoran; Xie, Hui; Zhu, Ning; Hu, Xin; Huang, Fang; Tan, Songwei

doi:10.1007/s12274-022-4285-7

Cited by 15 publications

(12 citation statements)

References 47 publications

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Section: Nanoparticlesmentioning

confidence: 99%

“…The co-delivery system could restore the balance of metabolism and inhibit inflammation in NPCs by inhibiting NFkB/ p65 and activating TGF/SMAD3 in vitro, ultimately inhibiting IDD in vivo (Figure 11n,o). [130] The use of these nanoplatforms may be an effective treatment for IDD. It is of great significance for follow-up research to determine the clinical efficacy of nano-sized delivery platforms.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…The co‐delivery system could restore the balance of metabolism and inhibit inflammation in NPCs by inhibiting NFkB/p65 and activating TGF/SMAD3 in vitro, ultimately inhibiting IDD in vivo (Figure 11n,o). [ 130 ]…”

Section: Therapy and Regaining Of Functionmentioning

confidence: 99%

mentioning

confidence: 99%

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Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

Zhou

et al. 2022

Adv Funct Materials

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Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging-associated disorder with a large socio-economic burden and a great decline in the quality of life, contributing to the pressing need for IVD treatments. Thus, finding effective disease-modifying approaches for postponing the progression of IVD degeneration and repairing degenerated intervertebral discs is of great importance, even facing various challengeable obstacles. Bioactive functional materials exhibit excellent advances in modulating cell activity and remodeling tissue homeostasis, which acts as a promising and accessible therapeutic approach to tissue repair and organ reconstruction. Recently, these have been notably explored to investigate bioactive functional materials-based repair strategies for intervertebral disc recovery and regeneration, including cell-based tissue engineering, the development of implants for disc recovery, and therapeutic methods for remodeling the functional integrity of the IVD. This review summarizes the advanced progress of bioactive functional materials in IVD repair and regeneration, and discusses their regulatory mechanisms, limitations, challenges as well as their clinical translational prospects in the future.

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Section: Nanoparticlesmentioning

confidence: 99%

Section: Nanoparticlesmentioning

confidence: 99%

Section: Therapy and Regaining Of Functionmentioning

confidence: 99%

mentioning

confidence: 99%

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Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

Zhou

et al. 2022

Adv Funct Materials

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“…The proton sponge method enables lysosomal escape by creating nanocarriers with buffering capacity that rupture endosomes through osmotic swelling. , Endosomal membrane fusion uses cationic liposomes or fusion peptides to evade lysosomes through electrostatic interactions with endosomes or conformational changes in acidic endosomes. − Plasma membrane penetration approach allows lysosomal escape by using features, such as the shape and charge of the nanoparticles to allow them to penetrate directly through the plasma membrane. − Unfortunately, many traditional lysosomal escape strategies face high cytotoxicity, short circulation and little chance of reaching the tumor, making clinical translation difficult. Viruses, as specialized intracellular parasites, have evolved a range of mechanisms for escaping the lysosome to deliver their genetic material to the cytoplasm for replication. − In recent years, inspired by viral infection mechanisms, the virus-mimicking nanoparticles has been developed, which can achieve effective delivery of drugs and has attracted great interest from researchers. − …”

mentioning

confidence: 99%

Inducing Autophagy and Blocking Autophagic Flux via a Virus-Mimicking Nanodrug for Cancer Therapy

Wang

Zhu

et al. 2022

Nano Lett.

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Maximizing the therapeutic capacity of drugs by allowing them to escape lysosomal degradation is a long-term challenge for nanodrug delivery. Japanese encephalitis virus (JEV) has evolved the ability to escape the endosomal region to avoid degradation of internal genetic material by lysosomes and further induce upregulation of cellular autophagy for the purpose of their mass reproduction. In this work, to exploit the lysosome escape and autophagy-inducing properties of JEV for cancer therapy, we constructed a virus-mimicking nanodrug consisting of anti-PDL1 antibody-decorated JEV-mimicking virosome encapsulated with a clinically available autophagy inhibitor, hydroxychloroquine (HCQ). Our study indicated that the nanodrug can upregulate the autophagy level and inhibit the autophagic flux, thereby inducing the apoptosis of tumor cells, and further activating the immune response, which can greatly improve the antitumor and tumor metastasis suppression effects and provide a potential therapeutic strategy for tumor treatment.

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