Alongside the development of the circular economy and sustainable food supply chains (FSCs), research on food loss and waste (FLW) reduction and prevention has drawn much attention from academia, practitioners, and governments. The significance of FLW has been highlighted in the literature due to its impact on society, economy, and the environment. We propose a conceptual framework to systematically examine FLW issues within FSCs in the field of operations management (OM). We discuss various types and distribution modes of FSCs where FLW occurs, definitions of FLW, the impacts of FLW, and measures to reduce FLW in the OM field. We further introduce the methodologies that have been applied in existing FLW studies. The contribution of this paper is threefold. First, it proposes a conceptual framework to identify FLW problems within FSCs. Second, it helps to comprehensively understand FLW occurrence and thus stimulate research focusing on FLW from different perspectives. Third, it motivates researchers to discuss FLW issues by applying different methodologies.