Co-Existence of Hepatocellular Carcinoma and Hepatic Tuberculosis

Limaïem, Faten; Gargouri, Faten; Bouraoui, Saâdia; Lahmar, Ahlem; Mzabi, Sabeh

doi:10.1089/sur.2012.177

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Currently, there have only been four other known cases of such synchronous presentations in the same patient. 5 , 6 More often, HTB is diagnosed during the work-up for a suspected HCC during histological evaluation. It also seems unlikely for tuberculosis to contribute to the pathogenesis of HCC.…”

Section: Discussionmentioning

confidence: 99%

A single hepatic mass with two tales: hepatic tuberculosis and hepatocellular carcinoma

Koh,

Leow

2023

JLC

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Hepatic tuberculosis (HTB) is an uncommon manifestation of tuberculous infections, and there has been no proven causal link between HTB and hepatocellular carcinoma (HCC). We herein present a rare case of a synchronous presentation of HTB and HCC within a single hepatic mass. A 57-year-old Chinese gentleman with recently diagnosed sigmoid adenocarcinoma was found to have a left lower lobe pulmonary nodule and solitary hepatic mass on staging computed tomography. Biopsies showed the hepatic mass to have both HTB and HCC components. This serves as a reminder that HTB is an important differential to consider for space-occupying lesions in the liver. Histological evaluation of suspected hepatic malignancies is recommended to exclude the presence of HTB in appropriate clinical settings.

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Section: Discussionmentioning

confidence: 99%

A single hepatic mass with two tales: hepatic tuberculosis and hepatocellular carcinoma

Koh,

Leow

2023

JLC

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“…Previous studies have implicated AFP in the regulation of cell growth, differentiation, apoptosis, angiogenesis, and immune regulation [47]. A few previous studies reported normal AFP in TB patients, but increased AFP in TB patients with hepatocellular carcinoma [48,49]. Monocytes can undergo homotypic fusion to produce different types of multinucleated giant cells in response to M. tuberculosis infection.…”

Section: Discussionmentioning

confidence: 99%

Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes

et al. 2020

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Background: Tuberculosis is a leading cause of death worldwide. BCG is an effective vaccine, but not widely used in many parts of the world due to a variety of issues. Mycobacterium vaccae (M. vaccae) is another vaccine used in human subjects to prevent tuberculosis. In the current study, we investigated the potential mechanisms of M. vaccae vaccination by determining differentially expressed genes in mice infected with M. tuberculosis before and after M. vaccae vaccination. Methods: Three days after exposure to M. tuberculosis H37Rv strain (5 × 10 5 CFU), adult BALB/c mice randomly received either M. vaccae vaccine (22.5 μg) or vehicle via intramuscular injection (n = 8). Booster immunization was conducted 14 and 28 days after the primary immunization. Differentially expressed genes were identified by microarray followed by standard bioinformatics analysis. Results: M. vaccae vaccination provided protection against M. tuberculosis infection (most prominent in the lungs). We identified 2326 upregulated and 2221 downregulated genes in vaccinated mice. These changes could be mapped to a total of 123 signaling pathways (68 upregulated and 55 downregulated). Further analysis pinpointed to the MyD88dependent TLR signaling pathway and PI3K-Akt signaling pathway as most likely to be functional. Conclusions: M. vaccae vaccine provided good protection in mice against M. tuberculosis infection, via a highly complex set of molecular changes. Our findings may provide clue to guide development of more effective vaccine against tuberculosis.

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“…The simultaneous occurrence of TB with HCC on the background of hepatitis C virus (HCV) has been rarely reported owing to potent anti-tubercular treatment nowadays. 5–7 We hereby report such a case.…”

Section: Introductionmentioning

confidence: 87%

Synchronous presentation of tuberculosis and hepatocellular carcinoma in a cirrhotic patient: a case report

et al. 2019

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Tuberculosis (TB) is a common opportunistic infection which may be reactivated in immunocompromised patients. The incidence of hepatocellular carcinoma (HCC) is on the rise with healthcare resulting in increased longevity of people. Reactivation of TB has been reported with liver-directed therapies for HCC like transarterial chemoembolisation (TACE) and transarterial radio-embolisation (TARE). However, the co-occurrence of both TB and HCC in the same patient without any such history is rarely found. Only three isolated case reports have been published previously. We report the case of an elderly hepatitis C virus-related chronic liver disease patient who developed two different nodular liver lesions with multiple intra-abdominal lymphadenopathy, one such nodule being confirmed as HCC and another as TB along with nodal TB.

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Co-Existence of Hepatocellular Carcinoma and Hepatic Tuberculosis

Cited by 5 publications

References 12 publications

A single hepatic mass with two tales: hepatic tuberculosis and hepatocellular carcinoma

A single hepatic mass with two tales: hepatic tuberculosis and hepatocellular carcinoma

Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes

Synchronous presentation of tuberculosis and hepatocellular carcinoma in a cirrhotic patient: a case report

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