Co-Infection of Dengue Virus by Serotypes 1 and 4 in Patient From Medium Sized City From Brazil

Colombo, Tatiana Elias; Vedovello, Danila; Reis, Andrea Francesli Negri; Cury, Amena Alcantara Ferras; Oliveira, Frank Hulder; Cruz, Lilian Elisa Arão Antônio; Bronzoni, Roberta Vieira de Morais; Nogueira, Maurício Lacerda

doi:10.1590/s0036-46652013000400009

Cited by 17 publications

(13 citation statements)

References 42 publications

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“…Some authors have noticed that concurrent infections by different DENV serotypes may increase severity due to increased virus titers and other factors 24 . The absence of a clinical correlation between co-infections and disease outcome has already been reported 8 .…”

Section: Discussionmentioning

confidence: 93%

“…Co-infections occur naturally and are not necessarily associated with increased disease severity. In Brazil, co-infections by DENV-2/DENV-3 were reported in Taua, in the state of Ceara 2 ; by DENV-2/DENV-4, DENV-1/DENV-2, DENV-1/DENV-4, and DENV-3/DENV-4 in Manaus AM 4 , 24 ; and by DENV-1/DENV-4 in Sao Jose do Rio Preto, SP 8 . Because clinical follow up was not performed in this study, it is not possible to determine whether co-infections resulted in increased disease severity.…”

Section: Discussionmentioning

confidence: 99%

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Dengue Outbreak in Mato Grosso State, Midwestern Brazil

Heinen

Zuchi

Cardoso

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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Dengue virus (DENV) is the most frequent arbovirus worldwide. In this study, we report a large outbreak in Mato Grosso State (MT). Serum samples from 604 patients with acute febrile illness for less than five days were inoculated in C6/36 cells, then infected cells were subjected to an indirect immunofluorescence test for DENV serotypes and yellow fever virus. Serum samples were submitted to a multiplex-semi-nested-RT-PCR for 11 flaviviruses. DENV-4 was isolated in 150/604 (24.8%) and DENV-1 in 19/604 (3.1%) specimens. By RT-PCR, 331 (54.8%) samples tested positive for DENV; 321 had single infections (DENV-4 n = 305; DENV-1 n = 15; DENV-3 n = 1), nine had co-infections of DENV-1/DENV-4, and one of DENV-2/DENV-4. DENV-4 was detected in 315/331 (95.2%) positive patients from 17 municipalities, and DENV-1 in 24/331 (7.2%) patients from five cities in north-central MT and the city of Cuiaba. The incidence of infection was higher in patients aged 20-39 (142/331; 42.9%). The NS5 partial nucleotide sequence of DENV-1 was most similar to that of genotype V, DENV-2 to Southeast Asian/American, DENV-3 to genotype III, and DENV-4 to genotype II strains, considered the most frequent strains in Brazil. This outbreak coincided with the introduction of DENV-4 in the state. Cuiaba was hyperendemic for the four DENV serotypes, highlighting the necessity for arbovirus surveillance in MT.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Dengue Outbreak in Mato Grosso State, Midwestern Brazil

Heinen

Zuchi

Cardoso

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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“…Co-infection with the serotypes DENV-1/-4 and DENV-2/-4 were observed in Mato Grosso state 41 ; co-infection with DENV-1/-4, in São José do Rio Preto, São Paulo state 42 ; co-infection with DENV-1/-4, DENV-2/-4, DENV-1/-2, and DENV-3/-4, in Manaus, Amazonas state11, 43, 44; co-infection with DENV-2/-3, in Tauá, Ceará state 45 ; co-infection with DENV-1/-2, in Barretos, São Paulo state 46 ; and co-infection with DENV-1/-2, in Cuiabá, Mato Grosso state 47, 48. Co-infections with more than one serotype were also detected in Ae.…”

Section: Denv-4mentioning

confidence: 94%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus.In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced clinical knowledge and improved general awareness about these arboviruses are indispensable to tackle diagnostic inadequacies.

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“…DENV-2, DENV-3, and DENV-4 were detected in 1998, 2005, and 2011, respectively (Mondini et al, 2009;Rocco et al, 2012). Colombo et al (2013) reported the first case of DENV-4 in 2011, simultaneously with the public health authority of the State, which detected this serotype in the same patient. In 2011, DENV-4 was detected co-circulating with the DENV-1 and DENV-2 (Souza et al, 2011), and caused major outbreaks in the next two years.…”

Section: Study Area and Timeframementioning

confidence: 99%