2013
DOI: 10.1007/s10953-013-0036-4
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Co-solubilization of the Hydrophobic Drugs Carbamazepine and Nifedipine in Aqueous Nonionic Surfactant Media

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Cited by 11 publications
(16 citation statements)
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“…Aqueous solubilization of water-insoluble materials is highly important for pharmaceuticals, detergency, emulsion polymerization, enhanced oil recovery, and textile dyeing. Among colloidal Self-assembled structures, micelles/vesicles are efficient solubilizers but the solubilization properties of bilayers of vesicles are superior [83,84]. A series of double-chained surfactants, with increasing chain length (C12-18) mixed with single chained dodecylethyldimethylammonium bromide (DODABB) solubilized curcumin thanks to hydrophobic-hydrophobic and electrostatic interactions with preservation of curcumin antioxidant activity in food [85].…”
Section: Novel Applications For Dodab Hybrid Assembliesmentioning
confidence: 99%
“…Aqueous solubilization of water-insoluble materials is highly important for pharmaceuticals, detergency, emulsion polymerization, enhanced oil recovery, and textile dyeing. Among colloidal Self-assembled structures, micelles/vesicles are efficient solubilizers but the solubilization properties of bilayers of vesicles are superior [83,84]. A series of double-chained surfactants, with increasing chain length (C12-18) mixed with single chained dodecylethyldimethylammonium bromide (DODABB) solubilized curcumin thanks to hydrophobic-hydrophobic and electrostatic interactions with preservation of curcumin antioxidant activity in food [85].…”
Section: Novel Applications For Dodab Hybrid Assembliesmentioning
confidence: 99%
“…Solubility of the pesticides was investigated at 298 K using visual examination and ultraviolet spectrophotometry according to the method reported by Masrat Maswal et al [23] Solubility of the pesticides was measured at 298 K in 25 wt% IL water solution prepared using a weighing balance (Sartorius, Germany) with an accuracy of ± 0.0001 g. The 5 mL sample vials containing 3 mL of IL solutions were saturated with pesticide. The solutions were agitated by vortex mixing for 10 min, and then placed in an ultrasonic bath (Crest Ultrasonics, USA) for 15 min.…”
Section: Solubility Studiesmentioning
confidence: 99%
“…Carbamazepine (CBZ) is an antiepileptic drug used in the treatment of epilepsy, trigeminal neuralgia and bipolar disorders, and Nifedipine (NFD) is a calcium channel blocker used for the treatment of hypertension and angina pectoris. 29 CBZ and NFD have low aqueous solubility and hence irregular and delayed absorption. An abnormal and excessive hypersynchronous ring within a group of epileptic neurons in the brain results in sudden alteration in motor activity and behavior.…”
Section: Introductionmentioning
confidence: 99%
“…37 There are reports where a patient with classical pattern of bipolar disorder with cycles of mania and depression responds to a combination of CBZ and NFD. 38 In our earlier work 29 we demonstrated that the single and simultaneous solubilization of CBZ and NFD in a single surfactant based micellar media is highly sensitive to the hydrophilic-lipophilic balance (HLB) value and the concentration of surfactants. The present study aims to enhance the micellar solubilization/co-solubilization of these drugs with simultaneous reduction in the amount of surfactant used by employing technologically more efficient surfactant mixtures.…”
Section: Introductionmentioning
confidence: 99%
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