Co-treatment with Fermented Black Raspberry and Red Ginseng Extracts Improves Lipid Metabolism and Obesity in Rats Fed with a High-fat and High-cholesterol Diet

이민정,; 최혜란,; 이정현,; 이수정,; 권지웅,; 최경민,; 차정단,; 황승미,; 박종혁,; 이상천,; 박필재,; 이태범,

doi:10.9721/kjfst.2015.47.3.364

Cited by 6 publications

(8 citation statements)

References 36 publications

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“…Recently, based on the information of health beneficial effects of bokbunja, the growth area and the harvest quantity in South Korea have rapidly increased resulting in various bokbunja products, such as juices and concentrates, rice cakes, vinegar, and dietary supplements. Several studies have shown that bokbunja fruit and wine are positively related with various physiological functions, including antioxidative , anti-inflammatory (Lim, Hwang, & Shin, 2012;Yang et al, 2007), anticancer (Jung et al, 2009), anti-high cholesterol (Lee et al, 2015), and prevention of the memory impairment (Choi, Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Yang

Choi

2016

CyTA - Journal of Food

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Bokbunja (Rubus coreanus Miquel) and six other berries were analyzed for physico-chemical properties and antioxidant activities, using four different methods (DPPH • , ABTS •+ , FRAP, and reducing power). The total polyphenol, total flavonoid, and total anthocyanin contents of bokbunja were significantly higher than those of other berries, followed by mulberry, blackberry, cranberry, raspberry, wild strawberry, and strawberry. Antioxidant activity assays also showed that bokbunja's antioxidant activity exceeded that of the other berries. Bokbunja had not only significantly higher levels of kaempferol, quercetin, and ellagic acid but also the highest ellagic acid content (408.57 mg kg −1 fresh weight). The potential antioxidant activities of bokbunja might be ascribed to its high total polyphenol, total flavonoid, and total anthocyanin contents. Ellagic acid may also affect antioxidant activity, although the concentrations of other phenolic compounds such as kaempferol, quercetin, and quercetin-3-O-rutinoside were high in other berries such as blackberry, cranberry, and mulberry.Comparación de la composición fenólica y la actividad antioxidante de la frambuesa negra coreana Bokbunja, (Rubus coreanus Miquel) con otros seis tipos de frutos del bosque RESUMEN Se analizaron la bokbunja (Rubus coreanus Miquel) y otros seis frutos del bosque para determinar sus propiedades fisicoquímicas y su actividad antioxidante utilizando cuatro métodos diferentes (DPPH • , ABTS •+ , FRAP y poder reductor). El contenido total de polifenoles, flavonoides y antocianina de la bokbunja fue significativamente más alto que aquel de otros frutos del bosque, seguido por el de las moras de Morus, las moras de Rubus, los arándanos rojos, las frambuesas, las fresas silvestres y las fresas. Los ensayos de actividad antioxidante mostraron también que la actividad antioxidante de la bokbunja excedió a aquella de los otros frutos del bosque. La bokbunja no solamente obtuvo unos niveles significativamente más altos de kaempferol, quercetina y ácido elágico, sino que también el mayor contenido de ácido elágico (408.57 mg kg −1 peso fresco). La potencial actividad antioxidante de la bokbunja podría ser atribuida a sus alto contenido total de polifenoles, flavonoides y antocianina. El ácido elágico también podría afectar a la actividad antioxidante, aunque las concentraciones de otros compuestos fenólicos como el kaempferol, la quercetina y la quercetina-3-O-rutinósido fueron más altas en otros frutos del bosque como las moras de Rubus, los arándanos rojos y las moras de Morus. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Yang

Choi

2016

CyTA - Journal of Food

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“…In vivo, Rats, fed high-fat/ high-cholesterol diet Cotreatment GBR and GE, 250 mg kg −1 day −1 , for 12 weeks ↓ Obesity Lee et al, (2015) In vivo, Obese female db/db mice GE, 4.5 g /kg/day, for 13 weeks ↓ BW ↓Adipose tissue mass ↓ Size of adipocytes in visceral adipose tissues In vivo, Mice, fed HFD Ginseng, 0.5 g kg −1 day −1 , for 15 weeks ↓ Body fat mass gain ↓ obesity Li et al, (2014) In vivo, Obese mice, Fed HFD Cotreatment Veratrum nigrum 0.75g kg day −1 and PG 0.75g kg day −1 , for 16 week ↓ fat weight, ↓ BW, ↓ LA Park et al, (2013) In vivo, Obese C57BL/6J mice, fed HFD GE,0.5 and 5 (w/w) daily for 8 weeks ↓ Adipose tissue mass ↓ Obesity…”

Section: Study Design Constituents Results Referencesmentioning

confidence: 99%

The effects of ginseng on the metabolic syndrome: An updated review

Aminifard

Razavi

Hosseinzadeh

2021

Food Science & Nutrition

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Metabolic syndrome or syndrome X is the name given to the collection of clinical conditions including overweight, high blood pressure, high blood glucose (or type 2 diabetes mellitus), and hyperlipidemia (Chen et al., 2017).Metabolic syndrome is the most important risk factor for atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction. Metabolic syndrome increases the risk of cardiovascular diseases. Cardiovascular diseases are the main reasons for mortality around the world . The metabolic syndrome is rising due to a sedentary lifestyle. Children, adolescents, and young women with polycystic ovary syndrome are at risk for metabolic syndrome (Vassallo et al., 2016).Medicine herbs, because of their potential efficacy in improving and holding human health, low cost, and adverse effects, have been the focus of attention. Studies have been shown that several plants and their active constituents can exert beneficial effects on metabolic syndrome. For example, grapes (Vitis vinifera), a source of polyphenol antioxidants, is useful for preventing the risk factors involved in metabolic syndromes such as hyperlipidemia, hypertension, and hyperglycemia (Akaberi & Hosseinzadeh, 2016). Garlic (Allium sativum) has been documented in the treatment of metabolic syndrome as it showed hypoglycemic, hypotensive, and hypolipidemic activities (Hosseini & Hosseinzadeh, 2015). Rosemary (Rosmarinus officinalis L.) is a source of phenolic phytochemicals having considerable anti-inflammatory, antioxidant, hypoglycemic, hypolipidemic, and hypotensive effects (Hassani et al., 2016).

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“…It was postulated that the high dietary fiber level and functional components of green tea powder improve the serum lipid profile by inhibiting the absorption of cholesterol and stimulate the excretion of bile acids ( Russell and Setchell, 1992 ). Many studies reported that vegetables and fruits by fermented LAB improved the serum lipid profiles ( Lee et al , 2015a ; Park et al , 2015 ). Moreover, the bioactive compounds of ML were increased by fermentation of LAB, and these results also indicated that the improvement of serum lipid profile was shown.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, fermentation is used to improve the nutrition values and increase the production and extraction yields of bioactive compounds in the vegetables and fruits. Many studies have reported that vegetables and fruits fermented by LAB exhibited high levels of polyphenolic and flavonoid compounds, and radical scavenging activity ( Lee et al , 2015a ; Lee et al , 2015b ; Lee and Paik, 2017 ; Park et al , 2015 ; Yang et al , 2014 ). Therefore, the fermented mulberry leaf using LAB are expected to have increased functionality due to increased content of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lactic Acid Bacteria-Fermented Mulberry Leaf Extract on the Improvement of Intestinal Function in Rats

Lee

Choi

et al. 2017

Korean Journal for Food Science of Animal Resources

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This study examined the laxative effects of mulberry leaf extract (MLE) fermented by lactic acid bacteria (LAB), which contains high levels of polyphenolic and flavonoid compounds, against loperamide-induced constipation in rats. Sprague-Dawley rats were divided into a normal group (N) and three experimental groups; loperamide treated group (C), loperamide and LAB-fermented MLE 300 mg/kg treated group (MLEL), and loperamide and LAB-fermented MLE 600 mg/kg treated group (MLEH). After 33 d, fecal pellet amount, fecal weight, water content of fecal, gastrointestinal transit time and length, and serum lipid profiles were measured. Constipation was induced via subcutaneous injection of loperamide (2.0 mg/kg b.w., twice a day) for the final 5 d of the experiment. After loperamide administration, the LAB-fermented MLE groups showed a significantly increase in the fecal pellets number, wet weight, and water content in rats compared with the C group. Moreover, increases in the intestinal length and viable Lactobacillus numbers in the feces were observed in the LAB-fermented MLE groups. The intestinal transit time was shorter in the LAB-fermented MLE groups than in the C group. In addition, the LAB-fermented MLE groups showed a significant decrease in triglyceride and total cholesterol levels and an increase in HDL-cholesterol level. These results indicated that oral administration of LAB-fermented MLE shows laxative effect in loperamide-induced constipated rats.

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Co-treatment with Fermented Black Raspberry and Red Ginseng Extracts Improves Lipid Metabolism and Obesity in Rats Fed with a High-fat and High-cholesterol Diet

Cited by 6 publications

References 36 publications

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

The effects of ginseng on the metabolic syndrome: An updated review

Effect of Lactic Acid Bacteria-Fermented Mulberry Leaf Extract on the Improvement of Intestinal Function in Rats

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