CO2-rich atmosphere strongly affects the degradation of Fe-21Mn-1C for biodegradable metallic implants

Essowe, Mouzou; Paternoster, Carlo; Tolouei, R.; Chevallier, Pascale; Biffi, Carlo Alberto; Tuissi, A.; Mantovani, Diego

doi:10.1016/j.matlet.2016.06.017

Cited by 26 publications

(23 citation statements)

References 19 publications

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“…Moreover, the addition of FBS to cell culture media always slows down the degradation of Mg alloys [ 7 , 50 , 51 , 63 , 64 ]. Similar results were obtained for iron-based materials, where the introduction of CO 2 in the presence of HBSS lead to different degradation products and patterns [ 65 ]. Therefore, cell culture media with FBS, such as, DMEM; MEM, Alpha-MEM, combined with the CO 2 /HCO 3 − buffering, are proposed to use for in vitro investigation for Mg and other biodegradable materials.…”

Section: Simulated or Not? The Question Of Appropriate Conditionssupporting

confidence: 78%

Magnesium degradation under physiological conditions – Best practice

González

Hou

Nidadavolu

et al. 2018

Bioactive Materials

202

130

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This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation. Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes, realistic and predictive in vitro setups are needed. Due to the complexity of these systems, the review gives an overview about technical measures, defines some caveats and can be used as a guideline for the establishment of harmonized laboratory approaches.

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Section: Simulated or Not? The Question Of Appropriate Conditionssupporting

confidence: 78%

Magnesium degradation under physiological conditions – Best practice

González

Hou

Nidadavolu

et al. 2018

Bioactive Materials

202

130

View full text Add to dashboard Cite

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“…In this work, the pH was adjusted to 7.4 by a bicarbonate buffer system which includes a CO 2 inlet. Mouzou et al [ 56 , 69 ] showed that the type of degradation products of in vitro corrosion measurements strongly depends on the exact composition of the used electrolyte. Furthermore, they demonstrated that the CO 2 content plays a key role.…”

Section: Discussionmentioning

confidence: 99%

“…The corrosion current density was determined by tafel extrapolation [ 53 , 54 ] in order to calculate the corrosion rates ( CR ) using Equation (1):

where j c = corrosion current density (Am −2 ), ρ = density 7690 kg/m 3 , M = molar mass 55 g/mol, n = 2 (number of elementary charges per reaction step), and F = Faraday constant. Based on investigations regarding the degradation mechanisms of Fe [ 55 ] and FeMn based alloys, [ 56 ] the anodic dissolution reaction follows Equations (2) and (3).

…”

Section: Methodsmentioning

confidence: 99%

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

2017

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Biodegradable metals are a topic of great interest and Fe-based materials are prominent examples. The research task is to find a suitable compromise between mechanical, corrosion, and magnetic properties. For this purpose, investigations regarding alternative fabrication processes are important. In the present study, magnetron sputtering technology in combination with UV-lithography was used in order to fabricate freestanding, microstructured Fe32Mn films. To adjust the microstructure and crystalline phase composition with respect to the requirements, the foils were post-deposition annealed under a reducing atmosphere. The microstructure and crystalline phase composition were investigated by scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Furthermore, for mechanical characterization, uniaxial tensile tests were performed. The in vitro corrosion rates were determined by electrochemical polarization measurements in pseudo-physiological solution. Additionally, the magnetic properties were measured via vibrating sample magnetometry. The foils showed a fine-grained structure and a tensile strength of 712 MPa, which is approximately a factor of two higher compared to the sputtered pure Fe reference material. The yield strength was observed to be even higher than values reported in literature for alloys with similar composition. Against expectations, the corrosion rates were found to be lower in comparison to pure Fe. Since the annealed foils exist in the austenitic, and antiferromagnetic γ-phase, an additional advantage of the FeMn foils is the low magnetic saturation polarization of 0.003 T, compared to Fe with 1.978 T. This value is even lower compared to the SS 316L steel acting as a gold standard for implants, and thus enhances the MRI compatibility of the material. The study demonstrates that magnetron sputtering in combination with UV-lithography is a new concept for the fabrication of already in situ geometrically structured FeMn-based foils with promising mechanical and magnetic properties.

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“…Furthermore, owing to including a high concentration of CO 2 gas in blood causing to create a uniform, compact and dense manganese carbonate crystals the degradation rate of Fe in vivo is slower than in vitro [50] and in most of the cases is longer than clinical needs [51]. Additionally, because of the low rate of blood circulation near the implants, utilization of Fe and its alloys for bone reconstruction purposes would be definitely lower than their corrosion rate.…”

Section: Disadvantages Of Fe and Its Alloysmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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CO2-rich atmosphere strongly affects the degradation of Fe-21Mn-1C for biodegradable metallic implants

Cited by 26 publications

References 19 publications

Magnesium degradation under physiological conditions – Best practice

Magnesium degradation under physiological conditions – Best practice

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

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