Coagulation in Sepsis

Jagneaux, Tonya; Taylor, David E.; Kantrow, Stephen P.

doi:10.1097/00000441-200410000-00002

Cited by 32 publications

(19 citation statements)

References 76 publications

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“…Proinflammatory cytokines act at various sites in hemostasis control, turning to a procoagulant state. [2,4,33] and have great importance in sepsis, being responsible for expression of tissue factor (TF). TF is a potent platelet aggregator and coagulation cascade activator.…”

Section: Coagulationmentioning

confidence: 99%

“…Many investigators have reported the intimate relationship between procoagulant and proinflammatory activities [3]. Coagulation abnormalities are a common occurrence in critically ill patients and have been associated with increased mortality [4]. Almost every patient with sepsis presents abnormalities in the coagulation system, ranging from a small decrease in platelet count and subclinical prolongation of clotting times to full-blown disseminated intravascular coagulation (DIC).…”

Section: Introductionmentioning

confidence: 99%

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Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats

Oliveira

Pires

Magrisso

et al. 2009

J Thromb Thrombolysis

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Sepsis is a systemic response to an infection that leads to a generalized inflammatory reaction. There is an intimate relationship between procoagulant and proinflammatory activities, and coagulation abnormalities are common in septic patients. Pharmaceutical studies have focused to the development of substances that act on coagulation abnormalities and on the link between coagulation and inflammation. Fructose-1,6-bisphosphate (FBP) is a high-energy glycolitic metabolite that in the past two decades has been shown therapeutic effects in great number of pathological situations, including sepsis. The aims of this study were to assess the effects of FBP on platelet aggregation in vitro and ex vivo in healthy and septic rats and evaluate the use of FBP as a treatment for thrombocytopenia and coagulation abnormalities in abdominal sepsis in rat. FBP inhibited platelet aggregation (P < 0.001) in vitro in healthy rats from the smallest dose tested, 2.5 mM, in a dose-dependent manner. The mean effective dose calculated was 10.6 mM. The highest dose tested, 40 mM, completely inhibited platelet aggregation (P < 0.001) induced by ADP. Platelet aggregation in plasma from septic rats was inhibited only with higher doses of FBP, starting from 20 mM (P < 0.001). The calculated mean effective dose was 19.3 mM. Ex vivo platelet aggregation in septic rats was significantly lower (P < 0.05) than healthy rats and the treatment with FBP, at the dose of 2 g/kg, diminished the platelet aggregation at the extension of 27% (P < 0.001), suggesting that FBP is a potent platelet aggregation inhibitor in vivo. Moreover, treatment with FBP 2 g/kg prevented thrombocytopenia (P < 0.001), prolongation of prothrombin and partial thromboplastin time (P < 0.001), but not fibrinogen, in septic rats. The most important findings in this study are that FBP is a potent platelet aggregation inhibitor, in vitro and ex vivo. It presents protective effects on coagulation abnormalities, which can represent a treatment against DIC. The mechanisms for these effects remain under investigation.

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Section: Coagulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats

Oliveira

Pires

Magrisso

et al. 2009

J Thromb Thrombolysis

View full text Add to dashboard Cite

show abstract

“…Two host responses proposed to play significant roles in tissue damage after sepsis are the inflammatory (Strassheim et al, 2002) and the hemostatic responses (Jagneaux et al, 2004). Sepsis is associated with a proinflammatory response characterized by an increase of proinflammatory cytokines such as interleukin (IL)-1␤, IL-6, or tumor necrosis factor (TNF)-␣.…”

mentioning

confidence: 99%

Metformin Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy

Bergheim

Luyendyk

Steele

et al. 2005

J Pharmacol Exp Ther

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Metformin [2-(N,N-dimethylcarbamimidoyl)guanidine] is a drug used in the treatment of type 2 diabetes. Recent studies have suggested that metformin may have effects in addition to lowering serum glucose concentrations (e.g., anti-inflammatory). The aim of the present study was to determine whether metformin prevents the inflammatory reaction and liver damage in a model of postsurgical sepsis. Accordingly, rats underwent 2/3 partial hepatectomy (PH; or sham surgery); 48 h after surgery, animals were administered endotoxin (LPS; 1.5 mg/kg i.v.). Both PH and LPS alone caused some minor liver damage. However, their combined effect (PH/LPS) was synergistic, leading to robust hepatic damage, as indicated by plasma enzymes and histological assessment. Although metformin treatment did not alter changes caused by PH alone, it almost completely blunted the effects of LPS in the PH/LPS group. Increases in biomarkers of inflammation (e.g., interleukin 6, interferon ␥, and neutrophil number) were also blunted by metformin treatment. Furthermore, PH/LPS caused a Ͼ200ϫ increase in hepatic plasminogen activator inhibitor 1 (PAI-1) mRNA expression and plasma PAI-1 protein. These increases were associated with inhibition of hepatic urokinase plasminogen activator activity and an increase in fibrin deposition, indicative of local thrombosis. These effects were markedly reduced by metformin treatment. In conclusion, these data demonstrate that metformin prevents liver damage in a model of postsurgical sepsis in rats by decreasing proinflammatory and hemostatic responses.

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“…[23] Numbers of observational reviews have indicated diminished levels of APC in fundamentally ill-patients that may have an immediate relationship with the mortality. [24] The danger of thromboembolism in the perioperative period is all around perceived. In this way, patients with hereditary thrombophilia ought to be given thromboprophylaxis.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Marine Polysachharides Used in the Treatment of Beleeding Disorder-a Review

Borah¹

2017

WJPPS

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Coagulation is the procedure by which blood changes from a fluid to a gel, framing a blood coagulation. It conceivably brings about haemostasis, the discontinuance of blood misfortune from a harmed vessel, trailed by repair. Ordinary coagulation pathway speaks to a harmony between the expert coagulant pathway that is in charge of clump development and the components that repress the same past the damage site. Unevenness of the coagulation framework may happen in the perioperative period or amid basic sickness, which might be optional to various variables prompting a propensity of either thrombosis or dying. Nature is dependably end up being the huge wellspring of medication for the humanity. Marine creatures are potential hotspot for medication disclosure. Life has begun from the seas that cover more than 70% of the surface of earth and contain exceedingly natural, concoction and natural assorted qualities beginning from miniaturized scale living beings to vertebrates. This differing qualities has been explanation behind remarkable substance mixes having pharmacological exercises. So this survey for the most part clarifies about the distinctive polysaccharides acquire from marine sources or its subsidiaries which influences the blood coagulation and instrument of activity of them on the coagulation of the blood framework.

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Coagulation in Sepsis

Cited by 32 publications

References 76 publications

Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats

Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats

Metformin Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy

Marine Polysachharides Used in the Treatment of Beleeding Disorder-a Review

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