Coconut kernel protein in diet protects the heart by beneficially modulating endothelial nitric oxide synthase, tumor necrosis factor-alpha, and nuclear factor-kappaB expressions in experimental myocardial infarction

Remya, S; Chikku, Anitha Madhusoodhanan; Renjith, R; Sakunthala, Arunima; Rajamohan, Thankappan

doi:10.1016/j.jfda.2013.07.012

Cited by 19 publications

(6 citation statements)

References 40 publications

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“…[ 10 ] Furthermore, lower levels of NO control cardiac function via the endothelial nitric oxide synthase (eNOS) pathway. [ 11 ] But, higher levels of NO, intervened by the inducible nitric oxide synthase (iNOS) can repress myocardial contractility and enhance the production of ROS, thereby causing cardiomyocyte apoptosis. [ 12 ] Thus, LPO, antioxidants, apoptosis, and endothelial dysfunction are strongly allied with the incidence and pathogenesis of MI.…”

Section: Introductionmentioning

confidence: 99%

β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction

Yovas

Ponnian

2021

J Biochem & Molecular Tox

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We planned to appraise the effects of β‐caryophyllene on Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in rats infarcted with isoproterenol. Rats were induced myocardial infarction by using isoproterenol (100 mg/kg body weight [b.w]). Serum creatine kinase‐MB, serum cardiac troponin‐T, heart weight, heart rate, and heart lipid peroxidation were greatly (p < 0.05) augmented, while heart enzymatic antioxidants and plasma nonenzymatic antioxidants were greatly (p < 0.05) lessened in isoproterenol‐treated rats. Reverse transcription‐polymerase chain reaction study revealed augmented expressions of Fas‐receptor and caspases 8, 9, and 3 genes in myocardial infarcted rats. Furthermore, iNOS protein expression was amplified and eNOS protein was lessened in the myocardial infarcted heart. Three weeks pre‐ and cotreatment with β‐caryophyllene (20 mg/kg b.w) greatly (p < 0.05) protected isoproterenol‐treated rats against these altered structural, biochemical, molecular, and immunohistochemical parameters, by its anti‐cardiac hypertrophic, anti‐tachycardial, antioxidant, anti‐apoptotic, and anti‐endothelial dysfunction effects. In conclusion, these findings projected the use of β‐caryophyllene for the therapy of human myocardial infarction after clinical trials.

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Section: Introductionmentioning

confidence: 99%

β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction

Yovas

Ponnian

2021

J Biochem & Molecular Tox

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“…31 The primary protective mechanism of protein hydrolysates may occur due to its anti-oxidative properties, and a similar observation was also demonstrated in many animal food-protein sources in vitro or in vivo. 32 Likewise, CLH supplementation reduced the serum TBARS values; Likewise, CLH supplementation reduced the serum TBARS values; meanwhile, reversed the reduced GSH levels and TEAC values in sera of HFD-fed mice ( Table 2). These findings indicated that CLHs alleviated systemic injury and oxidative stress.…”

Section: Discussionmentioning

confidence: 88%

Cardiac protection of functional chicken‐liver hydrolysates on the high‐fat diet induced cardio‐renal damages via sustaining autophagy homeostasis

Lin

Huang

et al. 2020

J Sci Food Agric

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BACKGROUND Cardio‐renal syndrome (CRS) is an integrative problem related to chronic malnutrition, obesity, etc. Amino acids and peptides are regarded as protective and essential for tissues. Pepsin‐digested chicken liver hydrolysates (CLHs), which are made from the byproducts of the poultry industry, are amino‐acid based and of animal origin, and may be protective against the myocardial and renal damage induced by a high‐fat diet (HFD). RESULTS Our results showed that CLHs contain large quantities of anserine, taurine, and branched‐chain amino acids (BCAAs), and supplementing the diet with CLHs reduced (P < 0.05) weight gain, liver weight, peri‐renal fat mass / adipocyte‐area sizes, serum total cholesterol (TC), aspartate aminotransferase (AST), and low‐density lipoprotein cholesterol (LDLC) levels in HFD‐fed mice but increased (P < 0.05) serum high‐density lipoprotein cholesterol (HDLC) levels. By histological analyses, CLHs alleviated (P < 0.05) renal lipid deposition and fibrosis, as well as cardiac fibrosis and inflammation of HFD‐fed mice. Meanwhile, increased (P < 0.05) inflammatory and fibrotic cytokines levels in the myocardia of the HFD‐fed mice were downregulated (P < 0.05) by CLH supplementation. Regarding autophagy‐related protein levels, protective effects of CLHs on the myocardia against HFD feeding may result from the early blockade of the autophagy pathway to prevent autophagosome accumulation. CONCLUSION Functional CLHs could be a novel food ingredient as a cardio‐renal protective agent against a high‐fat dietary habit in a niche market. © 2020 Society of Chemical Industry

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“…The elevation of ROS in the mitochondria induces ER to release calcium continuously through a channel in the membrane of ER, sending a feedback signal [ 36 ]. The increased ROS triggers inflammatory response through several complex mechanisms, including phosphorylation of JNK and NFκB nuclear translocation [ 37 , 38 ]. Li et al [ 4 ] confirmed that alleviation of ROS-associated ER stress resulted in a reduction in IL-1β secretion.…”

Section: Discussionmentioning

confidence: 99%

Long-chain bases from sea cucumber mitigate endoplasmic reticulum stress and inflammation in obesity mice

Wang

et al. 2017

Journal of Food and Drug Analysis

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Endoplasmic reticulum (ER) stress and inflammation can induce hyperglycemia. Long-chain bases (LCBs) from sea cucumber exhibit antihyperglycemic activities. However, their effects on ER stress and inflammation are unknown. We investigated the effects of LCBs on ER stress and inflammatory response in high-fat, fructose diet-induced obesity mice. Reactive oxygen species and free fatty acids were measured. Inflammatory cytokines in serum and their mRNA expressions in epididymal adipose tissues were investigated. Hepatic ER stress-related key genes were detected. c-Jun NH-terminal kinase and nuclear factor κB inflammatory pathways were also evaluated in the liver. Results showed that LCBs reduced serum and hepatic reactive oxygen species and free fatty acids concentrations. LCBs decreased serum proinflammatory cytokines levels, namely interleukin (IL)-1β, tumor necrosis factor-α, IL-6, macrophage inflammatory protein 1, and c-reactive protein, and increased anti-inflammatory cytokine IL-10 concentration. The mRNA and protein expressions of these cytokines in epididymal adipose tissues were regulated by LCBs as similar to their circulatory contents. LCBs inhibited phosphorylated c-Jun NH-terminal kinase and inhibitor κ kinase β, and nuclear factor κB nuclear translocation. LCBs also inhibited mRNA expression of ER stress markers glucose regulated protein, activating transcription factor 6, double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase, and X-box binding protein 1, and phosphorylation of eukaryotic initiation factor-α and inositol requiring enzyme 1α. These results indicate that LCBs can alleviate ER stress and inflammatory response. Nutritional supplementation with LCBs may offer an adjunctive therapy for RE stress-associated inflammation.

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Coconut kernel protein in diet protects the heart by beneficially modulating endothelial nitric oxide synthase, tumor necrosis factor-alpha, and nuclear factor-kappaB expressions in experimental myocardial infarction

Cited by 19 publications

References 40 publications

β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction

β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction

Cardiac protection of functional chicken‐liver hydrolysates on the high‐fat diet induced cardio‐renal damages via sustaining autophagy homeostasis

Long-chain bases from sea cucumber mitigate endoplasmic reticulum stress and inflammation in obesity mice

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