Coenzyme Q₁₀ Therapy

Abstract

For a number of years, coenzyme Q₁₀ (CoQ₁₀) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ₁₀. Also, at the inner mitochondrial membrane level, CoQ₁₀ is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ₁₀ affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ₁₀ supplementation may be due to this property. CoQ₁₀ deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ₁₀ levels as well as different ataxias and encephalomyopathies. CoQ₁₀ treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ₁₀ absorption and tissue distribution. Oral administration of CoQ₁₀ is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

Guidelines of the Russian scientific medical society of internal medicine on the diagnosis, treatment and rehabilitation of patients with the connective tissue dysplasia (first edition)

“…Курсовой прием лекарственных средств с кардио-энергетическим эффектом (Милдронат, Кудесан, Куде-вит), препаратов магния (Магне В6, Магне В6-форте, Диаспорал магний 300, Магнерот), антиоксидантов (Мексикор) [4][5][6][80][81][82][83][84][85][86][87][88]. Фундаментальные и клини-ческие исследования указывают на принципиальную важность обеспеченности организма омега-3 ПНЖК (Омакор) в комбинации с магнием для поддержания структуры соединительной ткани [4][5][6] [89][90][91][92].…”

Co-enzyme Q10 (Ubiquinone): It's Implication in Improving the Life Style of the Elderly

“…Supplementation of CoQ10 (1) prevented cardiac damage, liver toxicity, diarrhoea and stomatitis without decreasing the therapy effectiveness during chemotherapy with doxorubicin (4) (Figure 3) [43,44]. Chemotherapeutic drugs such as doxorubicin (4), camptothecin (5), etoposide (6), and methotrexate (7) (Figure 3) induced an increase in CoQ10 (1) levels in cancer lines by up regulation of CoQ7, CoQ4 and CoQ8 gene expression to protect from free radical damage [45]. Hence, foods and beverages containing CoQ10 (1) had been proposed for preventing cancer and mitigating the adverse reactions of cancer [46].…”

“…Its omnipresent nature gave the name ubiquinone. CoQ10 (1) supplementation reduced cardiovascular, fibromyalgia, diabetes mellitus, cancer, male infertility, periodontal, mitochondrial and neurodegenerative diseases [6]. Ubiquinol (2) (Figure 1), an electron-rich (reduced) form of CoQ10 (1) with an increased polarity showed improvement in its absorption and bioavailability [7].…”

“…CoQ10 (1) is involved in multiple cellular processes including proper uptake of CoQ10 (1) into cells which is crucial for the improvement of cell activity during aging [6]. The dietary supplementation of CoQ10 (1) can be a key strategy to improve the health in the elderly.…”

Possible Prophylaxes of Aloe Vera Juice with CoQ10 to Enhance Muscle Performance

“…CoQ10 deficiency could result from: (1) impaired CoQ10 synthesis due to nutritional deficiencies (such as vitamin B6 deficiency, a cofactor essential for CoQ10 biosynthesis); (2) a genetic or acquired defect in CoQ10 synthesis or utilization; or (3) increased tissue needs resulting from a particular disease. Since oral administration of CoQ10 can increase tissue levels of the nutrient, it is possible to correct CoQ10 deficiency and is particularly essential in the life-treating infantile encephalopathy [2] . CoQ10 may enhance aerobic capacity and muscle performance making it a great supplement for athletes and people suffering fatigue.…”