Coenzyme Q₁₀ enhances dermal elastin expression, inhibits IL‐1α production and melanin synthesis in vitro

Abstract

Coenzyme Q(10) (CoQ(10) ) is a well-known antioxidant and has been used in many skincare products for anti-ageing purpose. However, the molecular mechanisms of CoQ(10) function in skin cells are not fully understood. In this paper, we compared the effects of CoQ(10) on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ(10) treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR-induced matrix metalloproteinases-1 (MMP-1) level in embryonic and adult cells. In addition, CoQ(10) treatment increased elastin gene expression in cultured fibroblasts and significantly decreased UVR-induced IL-1α production in HaCat cells. Taken together, CoQ(10) presented anti-ageing benefits against intrinsic ageing as well as photo damage. Interestingly, CoQ(10) was able to inhibit tyrosinase activity, resulting in reduced melanin content in B16 cells. Thus, CoQ(10) may have potential depigmentation effects for skincare.

A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

“…Furthermore, treatment with coenzyme Q10 increased elastin gene expression in cultured fibroblasts and decreased UV radiation-induced interleukin-1 alpha (IL-1α) production in HaCat cells [56]. This evidence explains the presence of these two compounds into the dietary formulation object of our study.…”

“…Furthermore, pycnogenol improved skin elasticity and hydration in women presenting dry skin [54]. Coenzyme Q10 increased fibroblast proliferation, augmented expression of type IV collagen and reduced UV radiation-induced MMP-1 level in embryonic and adult cells (type IV collagen and MMP-1 have been implicated in photoaging [55]) [56].…”

Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines

“…Instead, we referred to the concentrations of these components found in human plasma following their dietary consumption [13–18]. On the basis of these plasmatic concentrations, most of the authors that previously evaluated in vitro the beneficial effects of such components on keratinocytes or other cells used the ranges of concentrations that are reported in Table 1 [19–38]. Since these components, used within these ranges of concentration, had always showed lack of toxicity and ability to efficiently decrease oxidative stress and/or inflammation in vitro , in the present work concentrations within these ranges were used.…”

Nanoemulsion Gel of Nutraceutical Co-Enzyme Q10 as an Alternative to Conventional Topical Delivery System to Enhance Skin Permeability and Anti-Wrinkle Efficiency

“…Co Q10 can decrease metalloproteinases that induced by UVA and UVB radiation. These metalloproteinase enzymes cleave collagen, basement membrane components, and elastic fibers, leading to wrinkling formation [54,55]. So it was expected the improvement of the efficiency of the Co Q10 action on skin wrinkles with increasing the amount of the drug targeted to the skin.…”