Coexisting Membranous Nephropathy and IgA Nephropathy

Nishida, Masashi; Kato, Ryuichi; Hamaoka, Kenji

doi:10.3109/15513815.2015.1087607

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…Similarly, Nishida et al . reported a pediatric case of coexisting MN and IgAN and suggested that overlapping MN and IgAN might not lead to deleterious outcomes 21 . The physiological and cellular mechanisms underlying the overlapping IMN and IgAN-associated increase in disease remission remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Chen

Shi

et al. 2017

Sci Rep

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Overlapping idiopathic membranous nephropathy (IMN) and immunoglobulin A nephropathy (IgAN) is rare. This study aims to investigate the unique prognostic, clinical, and renal histopathological characteristics of IMN+IgAN. This retrospective observational study included 73 consecutive cases of IMN+IgAN and 425 cases of IMN treated between September 2006 and November 2015. Prognostic and baseline clinical and histopathological data were compared between the two patient groups. Poor prognostic events included a permanent 50% reduction in eGFR, end-stage renal disease, and all-cause mortality. Renal histopathology demonstrated that the patients with IMN+IgAN presented with significantly increased mesangial cell proliferation and matrix expansion, increased inflammatory cell infiltration, and higher proportions of arteriole hyalinosis and lesions than the patients with IMN (all P < 0.05). Kaplan–Meier analysis showed that the patients with IMN+IgAN had significantly higher cumulative incidence rates of partial or complete remission (PR or CR, P = 0.0085). Multivariate Cox model analysis revealed that old age at biopsy and high baseline serum creatinine and uric acid levels were significantly associated with poor prognosis (all P < 0.05), and increased IgA expression correlated significantly with PR or CR (P < 0.05). The present study found that overlapping IMN and IgAN presents with unique renal histopathology and appears not to cause a poorer prognosis than IMN.

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Section: Discussionmentioning

confidence: 99%

Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Chen

Shi

et al. 2017

Sci Rep

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“…Existe escasa información sobre la GC, especialmente, en pediatría. 1,2,4 Cheong et al encontraron, en 294 niños, 9 casos de GC (3,1%). 1 En adultos, Monga y colaboradores hallaron 9 casos de GC entre 1715 biopsias de pacientes adultos (0,5%), 5 y Bertani, 7 entre 105 biopsias renales (7%).…”

Section: Discussionunclassified

“…1,13,14 No hay evidencia de que la presencia de GC empeore el pronóstico renal de los pacientes más allá de lo que se espera para cada entidad aislada. 2,12,15 Se desconoce si la aparición de un segunda glomerulopatía es coincidencia o se trata de una entidad glomerular única diferente con un mecanismo patogénico común. 2,12 En conclusión, las GC son infrecuentes en los niños y su presentación es muy variable, por lo que es necesaria la biopsia renal para su diagnóstico definitivo.…”

Section: Discussionunclassified

Glomerulopatías combinadas: comunicación de 2 casos pediátricos

Pinto

Balbarrey

Adragna

2018

Arch Argent Pediatr

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“…In this report, SLE and T1DM co-exist more often than expected based on the prevalence of both diseases. Several case reports describe different overlapping auto-immune diseases that affect the kidney, such as MN and IgA nephropathy 29 or MN and further extra-renal autoimmune diseases such as colitis ulcerosa) 30 . More detailed and better powered studies focusing on SNP associations across sub-types of different autoimmune diseases are required to address these important questions in more detail.…”

Section: Discussionmentioning

confidence: 99%

Associations between genetic risk variants for kidney diseases and kidney disease etiology

Wunnenburger

Schultheiss

Walz

et al. 2017

Sci Rep

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Chronic kidney disease (CKD) is a global health problem with a genetic component. Genome-wide association studies have identified variants associated with specific CKD etiologies, but their genetic overlap has not been well studied. This study examined SNP associations across different CKD etiologies and CKD stages using data from 5,034 CKD patients of the German Chronic Kidney Disease study. In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10 −7 ), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10 −6 ), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10 −4 ) and to type 1 diabetes (p = 4.6 × 10 −11 ). Associations were independent of additional risk variants in the respective genetic regions. Evaluation of CKD stage showed a significant association of the UMOD risk variant, previously identified in population-based studies for association with kidney function, for advanced (stage ≥G3b) compared to early-stage CKD (≤stage G2). Shared genetic associations across CKD etiologies and stages highlight the role of the immune response in CKD. Association studies with detailed information on CKD etiology can reveal shared genetic risk variants.The prevalence of chronic kidney disease (CKD) is high with >10% of the adult population affected in many countries 1 . Its genetic architecture is complex and incompletely understood. Genome-wide association studies (GWAS) have helped to gain insight into complex disease genetics 2,3 by identifying single-nucleotide polymorphisms (SNPs) in >70 independent risk loci associated with the estimated glomerular filtration rate (eGFR), CKD disease risk and microalbuminuria (MA) 4-6 as well as specific kidney diseases such as IgA 7,8 or membranous nephropathy 9 in case control studies. Because many of these specific kidney diseases are individually rare, only very few studies have collected sufficient numbers of patients with CKD attributed to various of these specific etiologies using one study design and protocol. Consequently, genetic risk variants identified in association with a specific etiology of CKD have so far not been examined for their association with CKD attributed to other etiologies. Capitalizing on data from the large German Chronic Kidney Disease (GCKD) study, we therefore aimed to systematically examine whether risk loci discovered for specific etiologies of CKD, especially for autoimmune conditions 10 , are associated with other CKD etiologies as well. Additionally, we aimed to examine whether risk loci discovered in the general population are also associated with advanced stages of CKD and with CKD in patients for whom the leading cause of disease was hypertension or diabetes, the most common causes of CKD. Subjects and MethodsThe GCKD study 11,12 is an ongoing prospective ob...

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Coexisting Membranous Nephropathy and IgA Nephropathy

Cited by 5 publications

References 8 publications

Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Glomerulopatías combinadas: comunicación de 2 casos pediátricos

Associations between genetic risk variants for kidney diseases and kidney disease etiology

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