CoFe₂O₄@SiO₂‐PA‐CC‐guanidine nanoparticles: A novel, efficient, and recyclable catalyst for the synthesis of 3,5‐disubstituted‐2,6‐dicyanoaniline derivatives

Abstract

A new and efficient procedure for the synthesis of 3,5‐disubstituted‐2,6‐dicyanoaniline derivatives by CoFe2O4@SiO2‐PA‐CC‐guanidine magnetic nanoparticles (MNPs) was reported. 3,5‐Disubstituted‐2,6‐dicyanoaniline derivatives were synthesized from malononitrile, aldehydes, and β‐nitrostyrene derivatives in good yields. MNPs used for the synthesis of aniline derivatives were easy to recover and reuse. The CoFe2O4@SiO2‐PA‐CC‐guanidine MNPs were characterized by Fourier‐transform infrared spectroscopy, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, thermogravimetric analysis, and vibration sample magnetometry techniques.

Nanomagnetic CoFe2O4@SiO2-EA-H3PO4 as a zwitterionic catalyst for the synthesis of bioactive pyrazolopyranopyrimidines and dihydropyrano[2,3-c]pyrazoles

“…The CoFe 2 O 4 @SiO 2 core–shell was synthesized using the method that has been previously documented. 24 In the subsequent step, 1.5 g of nanoparticles obtained from the previous step were dispersed in 50 mL of H 2 O for 10 min. The dispersion was then combined with 2 g of 2-chloroethylamine hydrochloride, followed by the addition of 1.5 g of NaHCO 3 .…”

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

“…In order to consolidate the advantageous features of homogeneous catalysts and heterogeneous catalysts while mitigating their respective drawbacks, researchers have developed a catalyst that incorporates nanoparticles. [50,51] In recent years, there has been a notable increase in the utilization of nanotechnology, particularly in the realm of organic synthesis, spanning a period of around twenty years [45] and specifically nanoparticles possess several notable attributes, including heightened activity, an expansive active surface area, exceptional selectivity, stability, and the potential to be recovered and reused (Figure 3). The separation of nanoparticles from the reaction mixture presents challenges due to their small size, necessitating the use of advanced techniques such as filtering or centrifugation.…”

Review on synthesis of pyrrole derivatives promoted by nanoparticles

“…[52] Nanoparticles are separated from the reaction mixture using filtration or centrifuging, [53] but according to the small size of the nanoparticles, separating them is a tedious work and requires advanced tools. Magnetic nanoparticles (MNPs) [54,55a,b] [56] and separation of these nanoparticles in comparison to other nanoparticles is comfortable and easily separated from the reaction mixture using an external magnet [57] and has the capability of recovery and reusability for several times. In recent years, synthesis of different heterocycle compounds such as pyrroles, pyridopyrimidines, [58] pyranes, [59] pyridines, [59] pyrazolopyranopyrimidines, [60] thiazoles, [61] tetrazoles, [62] quinazolines, [63] polyhydroquinolines [63] derivatives, and some other heterocycles, using nanoparticles due to the advantages of this catalysts in compare to homogeneous and heterogeneous catalysts, is increased.…”