Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis

Gullo, Hannah; Fleming, Jennifer; Bennett, Sally; Shum, David

doi:10.1016/j.msard.2019.03.024

Cited by 43 publications

(46 citation statements)

References 25 publications

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“…The relation between fatigue and impaired QOL has been found in several other studies as well. 3,4,6–8,18,22 One recent study found a correlation between mental QOL and cognitive fatigue, as well as physical QOL and motor fatigue, supporting our results. 8 Another study found similar results but noted that the different components of fatigue (physical, cognitive, social role and psychological dimension) each correlated equally with all dimensions of QOL.…”

Section: Discussionsupporting

confidence: 89%

“…The knowledge on the different impact of motor and cognitive fatigue may prove helpful for clinicians in predicting potential problems related to areas of QOL among MS-patients and have implications for the choice of treatment and care. 8 For example, mental QOL and cognitive fatigue (but not physical) has shown to correlate to depression, 7,18,23 suggesting early interventions targeted at psychological problems among this group of patients, in order to reduce fatigue and improve QOL. Moreover, Amantadine has shown to have a positive effect on fatigue, but no effect on depression, which might indicate that it is most effective on patients in whom physical fatigue is predominant.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,6,7 However, it is now clear that unidimensional views of fatigue and QOL are obsolete, emphasizing the need for examining cognitive and motor fatigue, as well as mental and physical QOL, separately. 8 This will contribute to a better understanding of the complex nature of fatigue and the role it plays in the daily life of MS patients, which is the first step towards improving current treatment strategies. This has only been examined in a few studies, 9–11 pointing towards the need for further research in this field.…”

Section: Introductionmentioning

confidence: 99%

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Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Ruban

Hilt

Petersen

2021

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Multiple sclerosis is a chronic disease leading to reduced quality of life. Objectives To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability. Methods 79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records. Results All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life. Conclusion Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Ruban

Hilt

Petersen

2021

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…These results are consistent with available studies. Other authors as well confirmed that EDSS score [9], fatigue [9, 19-21, 25, 28], disability [19, 20, 25], and quality of sleeping [9, 21] were found to be more predictive of QoL.…”

Section: Discussionmentioning

confidence: 75%

“…To evaluate the QoL of MS patients, studies use both generic and specific questionnaires. Most frequently, the following generic questionnaires are used: SF-36 [11, 18, 27], WHOQoL-Bref [23, 24], EQ-D-3L [22, 28], and the specific questionnaire Multiple Sclerosis Quality of Life MSQOL-54 [10, 17, 19-21, 26, 27]. In many cases, these specific tools are not culturally acceptable for all countries; thus, it seems more convenient to create a specific questionnaire that would be appropriate for this population.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers

Bužgová

Kozáková

Škutová³

2020

Eur Neurol

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Background: Only a few studies have been done focusing on the quality of life (QoL) of patients with multiple sclerosis (MS) as well as their family members. The aim of our research was to determine the factors that influence the QoL of MS patients in advanced stage of disease and their caregivers. Methods: The sample of the cross-sectional study included 153 patients with MS and 74 caregivers. QoL was measured using the PNDQoL questionnaire (Progressive Neurological Diseases Quality of Life), and the severity of illness was assessed through the following scales: EDSS (Expanded Disability Status scale), PPS (Palliative Performance Scale), and ADL (Activity Daily Living). Results: The following predictors of the global QoL of the MS patients were identified – age, EDSS, symptom burden, daily care, emotional functioning, and spiritual_nonreligion functioning (R2 = 0.569; F = 32.900; p < 0.001). The following predictors of the global QoL of caregivers were identified – age, emotional functioning, spiritual_nonreligion functioning, patient’s QoL, and feeling of care (R2 = 0.431; F = 18.690; p < 0.001). Conclusion: Appropriate intervention should be directed particularly at older patients and caregivers who have faced the disease for longer time and at patients without any partner. Supporting the emotional and social well-being and mitigating the burden caused by symptoms of the patients as well as caregivers can improve the QoL of both groups.

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The feasibility of a flexible exercise participation programme (FEPP) for individuals with multiple sclerosis

Smith

Williams

Jordan

et al. 2022

Physiotherapy Res Intl

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Background and purpose: Individuals with multiple sclerosis (MS) want health advice regarding participation in their choice of exercise. To address this need, a flexible exercise participation programme (FEPP) was developed, underpinned by the MS aerobic exercise guidelines and supported by a physiotherapist using behaviour change techniques. The aim of this study was to investigate the feasibility of the FEPP for individuals with minimal disability from MS. Methods: A feasibility study utilising a single group pre/post-intervention design was conducted. The 12-week FEPP was completed by 10 individuals with MS (EDSS 0-3.5). Exercise progression in duration, intensity or frequency of exercise (in line with MS exercise guidelines) was guided by a self-perceived weekly energy level score, and weekly telephone coaching sessions using behavioural change techniques. Trial feasibility was assessed via measures of process (recruitment and retention), resources/management (communication time; data entry) and scientific feasibility (safety; compliance). Secondary FEPP feasibility outcomes included the Goal Attainment Scale (GAS) T-score, exercise participation (weekly exercise diary), high-level mobility (HiMAT), vitality (Subjective Vitality Scale), biomarkers for inflammation (cytokines levels [IL2, IL4, IL6, IL10, TNF and IFNγ]), and acceptability (participant survey).Results: Process: In total, 11 (85%) of 13 eligible participants enroled at baseline with 10 (91%) completing the study. Resources/management: Coaching sessions included a baseline interview-mean 39 min (SD: 6.6) and telephone coachingmean 10 min (SD: 3.8) per week. Outcome measure data collection time-mean 44 min (SD: 2.1). Scientific feasibility: Two participants experienced a fall during their exercise participation. Self-reported compliance was high (99%). GAS T-scores increased significantly, indicating achievement of exercise participation goals. Secondary outcomes showed trends towards improvement. Discussion:The FEPP was feasible, safe and highly acceptable for use with individuals with MS and warrants a larger trial to explore effectiveness.

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Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis

Abstract: Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis., Multiple Sclerosis and Related Disorders (2019), doi:

Cited by 43 publications

References 25 publications

Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers

The feasibility of a flexible exercise participation programme (FEPP) for individuals with multiple sclerosis

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