Cognitive Correlates of Cerebral White Matter Lesions and Water Diffusion Tensor Parameters in Community-Dwelling Older People

Shenkin, Susan D.; Bastin, Mark E.; MacGillivray, Tom; Deary, Ian J.; Starr, John M.; Rivers, Carly S.; Wardlaw, Joanna M.

doi:10.1159/000087930

Cited by 87 publications

(81 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There existed a significant association between white matter lesion load and severity of DTI and MTR measures in the normalappearing white matter with the microstructural changes in normal brain tissue being more closely related to the patients' clinical presentation than the volume of visible white matter abnormalities [9,32,52,61,69,70,74,92,93]. These observations clearly indicate that age-related small vessel disease of the brain is a diffuse process affecting the entire brain and that white matter lesions are probably only the tip of the iceberg.…”

Section: Age-related White Matter Changes and Normal-appearing Brain mentioning

confidence: 83%

Heterogeneity in age-related white matter changes

et al. 2011

View full text Add to dashboard Cite

White matter changes occur endemically in routine magnetic resonance imaging (MRI) scans of elderly persons. MRI appearance and histopathological correlates of white matter changes are heterogeneous. Smooth periventricular hyperintensities, including caps around the ventricular horns, periventricular lining and halos are likely to be of non-vascular origin. They relate to a disruption of the ependymal lining with subependymal widening of the extracellular space and have to be differentiated from subcortical and deep white matter abnormalities. For the latter a distinction needs to be made between punctate, early confluent and confluent types. Although punctate white matter lesions often represent widened perivascular spaces without substantial ischemic tissue damage, early confluent and confluent lesions correspond to incomplete ischemic destruction. Punctate abnormalities on MRI show a low tendency for progression, while early confluent and confluent changes progress rapidly. The causative and modifying pathways involved in the occurrence of sporadic age-related white matter changes are still incompletely understood, but recent microarray and genome-wide association approaches increased the notion of pathways that might be considered as targets for therapeutic intervention. The majority of differentially regulated transcripts in white matter lesions encode genes associated with immune function, cell cycle, proteolysis, and ion transport. Genome-wide association studies identified six SNPs mapping to a locus on chromosome 17q25 to be related to white matter lesion load in the general population. We also report first and preliminary data that demonstrate apolipoprotein E (ApoE) immunoreactivity in white matter lesions and support epidemiological findings indicating that ApoE is another factor possibly related to white matter lesion occurrence. Further insights come from modern MRI techniques, such as diffusion tensor and magnetization transfer imaging, as they provide tools for the characterization of

show abstract

Section: Age-related White Matter Changes and Normal-appearing Brain mentioning

confidence: 83%

Heterogeneity in age-related white matter changes

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Shenkin et al [25] Subcortical and periventricular WMLs were not associated with any of the cognitive measurements.…”

Section: Reference Associationmentioning

confidence: 92%

“…Based on their proximity to ventricles, WMLs were classified as subcortical or periventricular in seven studies [24][25][26][27][28]33,34]. The results show that more studies have found an association between periventricular WMLs with the cognitive domain of executive function, than subcortical WMLs.…”

Section: Subcortical Vs Periventricular Wmlsmentioning

confidence: 99%

“…Studies that did not compare subjects based on cognitive status Subcortical vs. periventricular WML Five studies [24][25][26][27][28] -four cross-sectional studies and one prospective study -compared the association of subcortical versus periventricular WMLs with cognitive function. In the first cross-sectional study of 1077 older adults [24], WMLs were defined as T2 and PD hyperintensities that were not T1 hypointensities.…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…Three regions adjacent to frontal horns, lateral ventricles wall, and occipital horns were selected for periventricular WML scoring. The In the second cross-sectional study of 105 older adults [25], WMLs were identified using T2 and FLAIR scans. Results showed that higher periventricular and subcortical WML scores were not significantly associated with reduced memory and executive function/processing speed.…”

Section: Overview Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

P3‐200: The association between cognitive function and white matter lesion location in older adults: A systematic review

Bolandzadeh

Davis

Tam

et al. 2012

Alzheimer's & Dementia

View full text Add to dashboard Cite

Background: Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults. However, whether their anatomical location moderates these associations is not well-established. This review systematically evaluates peer-reviewed evidence on the role of anatomical location in the association between WMLs and cognitive function. Methods: In accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement, databases of EMBASE, PUBMED, MEDLINE, and CINAHL, and reference lists of selected papers were searched. We limited our search results to adults aged 60 years and older, and studies published in the English language from 2000 to 2011. Studies that investigated the association between cognitive function and WML location were included. Two independent reviewers extracted: 1) study characteristics including sample size, sample characteristic, and study design; 2) WML outcomes including WML location, WML quantification method (scoring or volume measurement), strength of the MRI magnet in Tesla, and MRI sequence used for WML detection; and 3) cognitive function outcomes including cognitive tests for two cognitive domains of memory and executive function/processing speed. Results: Of the 14 studies included, seven compared the association of subcortical versus periventricular WMLs with cognitive function. Seven other studies investigated the association between WMLs in specific brain regions (e.g., frontal, parietal lobes) and cognitive function. Overall, the results show that a greater number of studies have found an association between periventricular WMLs and executive function/processing speed, than subcortical WMLs. However, whether WMLs in different brain regions have a differential effect on cognitive function remains unclear. Conclusions: Evidence suggests that periventricular WMLs may have a significant negative impact on cognitive abilities of older adults. This finding may be influenced by study heterogeneity in: 1) MRI sequences, WML quantification methods, and neuropsychological batteries; 2) modifying effect of cardiovascular risk factors; and 3) quality of studies and lack of sample size calculation.

show abstract

White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population

Vernooij¹,

Ikram²,

Vrooman³

et al. 2009

Arch Gen Psychiatry

286

242

View full text Add to dashboard Cite

show abstract

Cognitive Correlates of Cerebral White Matter Lesions and Water Diffusion Tensor Parameters in Community-Dwelling Older People

Abstract: DT-MRI parameters, in particular , are sensitive to early ultrastructural changes underlying cognitive ageing. Executive function may be the cognitive domain most sensitive to age-related decline in white matter tract integrity.

Cited by 87 publications

References 58 publications

Heterogeneity in age-related white matter changes

Heterogeneity in age-related white matter changes

P3‐200: The association between cognitive function and white matter lesion location in older adults: A systematic review

White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population

Contact Info

Product

Resources

About