Cognitive effects of diphenyl diselenide and estradiol treatments in ovariectomized mice

Rocha, Juliana Trevisan da; Sampaio, Tuane Bazanella; Neto, José S. S.; Nogueira, Cristina W.; Zeni, Gilson

doi:10.1016/j.nlm.2012.10.005

Cited by 10 publications

(5 citation statements)

References 60 publications

(87 reference statements)

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“… 20 However, there is little information regarding the role of ovarian hormones in infections by Gram-positive bacteria, such as S. aureus . Ovariectomy significantly reduces the level of ovarian hormones, and the success of this surgery can be confirmed by uterine atrophy 21 and by reduction of serum estradiol levels, as was seen in all ovariectomized females compared to shams of this study. In the present study, there was no difference in bacterial load in blood between shams and ovariectomized females.…”

Section: Discussionsupporting

confidence: 73%

Ovarian hormones influence immune response to Staphylococcus aureus infection

Souza

Oliveira

Júnior

et al. 2020

The Brazilian Journal of Infectious Diseases

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Section: Discussionsupporting

confidence: 73%

Ovarian hormones influence immune response to Staphylococcus aureus infection

Souza

Oliveira

Júnior

et al. 2020

The Brazilian Journal of Infectious Diseases

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“…Given the array of cellular, morphological, and structural changes associated with declining E2 levels, reduced dendritic spines, decreased synaptic density, decreased numbers of specific synapses, changes in connectivity, and increases or reductions in gray matter volume in specific areas, it is unsurprising that there are associated cognitive changes. In preclinical models of menopause, ovariectomizing young rodents produced a reduction in performance in a spatial learning tasks, including the radial arm maze and the morris water maze [51][52][53]. In young and middle aged ovarectomised rodents, E2 supplementation has been shown to normalize these deficits [51,54].…”

Section: Effects On Cognition Of E2 Loss or Replacementmentioning

confidence: 99%

The Role of Estrogen in Brain and Cognitive Aging

2019

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There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline rapidly over the menopausal transition. This decline in E2 has been associated with a number of changes in the brain, including cognitive changes, effects on sleep, and effects on mood. These effects have been demonstrated in both rodent and non-human preclinical models. Furthermore, E2 interactions have been indicated in a number of neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. In normal brain aging, there are a number of systems that undergo changes and a number of these show interactions with E2, particularly the cholinergic system, the dopaminergic system, and mitochondrial function. E2 treatment has been shown to ameliorate some of the behavioral and morphological changes seen in preclinical models of menopause; however, in clinical populations, the effects of E2 treatment on cognitive changes after menopause are mixed. The future use of sex hormone treatment will likely focus on personalized or precision medicine for the prevention or treatment of cognitive disturbances during aging, with a better understanding of who may benefit from such treatment.

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“…We used spontaneous alternation T-maze test to evaluate cognitive function in TBI mice as performed previously [36,37]. A T-maze was made of black plastic and consisted of a central arm (50 cm × 10 cm, walls 15 cm height) and two lateral arms (32 cm × 10 cm, walls 15 cm height).…”

Section: T-maze Testmentioning

confidence: 99%

Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice

Chen

Man

Yao

et al. 2022

Preprint

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Traumatic brain injury (TBI) is a major risk factor to develop epilepsy and cognitive impairments. Neuropeptide oxytocin has been previously evidenced to produce antiepileptic effects. However, the involvement of central oxytocin in TBI-induced epileptic status and cognitive dysfunctions is not fully elucidated. In this study, we aim to investigate the role of oxytocin on a TBI model followed by seizure induction to clarify whether the epilepsy and cognitive deficits could be mitigated by oxytocin. TBI was established by weight drop and epileptic behaviors were induced by pentylenetetrazole (PTZ) injection in mice. Moreover, oxytocin was microinjected into the medial prefrontal cortex (mPFC) to observe the effects on the epilepsy and cognition. The blood-brain barrier (BBB) function and the neuroinflammation were measured by Evans Blue staining and enzyme-linked immunosorbent assays, respectively. Mice exposed to TBI demonstrate increased vulnerability to PTZ-mediated seizures and cognitive disturbances with a decrease in peripheral and brain oxytocin levels. Additionally, TBI reduces oxytocin, disrupts the BBB permeability and triggers neuroinflammation in mPFC in PTZ-treated mice. Intra-mPFC oxytocin simultaneously mitigates epilepsy and cognitive impairments. Finally, oxytocin restores BBB integrity and reduces mPFC inflammation in PTZ-treated TBI mice. These findings showed that intra-mPFC oxytocin suppressed the seizure vulnerability and cognitive deficits in TBI mice. The normalization of BBB integrity and inhibition of neuroinflammation may be involved in the antiepileptic and cognition-improved effects of oxytocin, suggesting that targeting inflammatory procedure in mPFC may decrease the risk to develop epilepsy and cognitive impairments in individuals previously experienced TBI.

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Cognitive effects of diphenyl diselenide and estradiol treatments in ovariectomized mice

Cited by 10 publications

References 60 publications

Ovarian hormones influence immune response to Staphylococcus aureus infection

Ovarian hormones influence immune response to Staphylococcus aureus infection

The Role of Estrogen in Brain and Cognitive Aging

Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice

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