Cohort profile: Risk evaluation of cancers in <scp>C</scp>hinese diabetic individuals: a longitudinal (<scp>REACTION</scp>) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)

Bi, Yufang; Lu, Jieli; Wang, Weiqing; Mu, Yiming; Zhao, Jiajun; Liu, Chao; Chen, Lulu; Shi, Lixin; Li, Qiang; Wan, Qin; Wu, Shengli; Yang, Tao; Yan, Li; Liu, Yan; Wang, Guixia; Luo, Zuojie; Tang, Xulei; Chen, Gang; Huo, Yanan; Gao, Zhengnan; Su, Qing; Ye, Zhen; Wang, Youming; Qin, Guijun; Deng, Hongkuan; Yu, Xuefeng; Shen, Feixia; Chen, Li; Zhao, Liebin; Zhang, Jie; Sun, Jichao; Dai, Meng; Xu, Min; Xu, Yu; Chen, Yuhong; Lai, Shenghan; Bloomgarden, Zachary T.; Li, Donghui; Ning, Guang

doi:10.1111/1753-0407.12108

Cited by 168 publications

(148 citation statements)

References 24 publications

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“…Physical activity was estimated by the Global Physical Activity Questionnaire and was measured by the metabolic equivalent 16. Measurements of anthropometry, including weight, standing height and waist circumference, were carried out by trained nurses according to a standard protocol 17. An electronic sphygmomanometer (OMRON Model HEM‐725FUZZY; Omron Company, Dalian, China) was used to measure blood pressure three times consecutively on the non‐dominant arm with a 3‐min interval after a 5‐min rest.…”

Section: Methodsmentioning

confidence: 99%

Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Liu

Qiu

Yuan

et al. 2018

J of Diabetes Invest

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Aims/IntroductionLimited data are available regarding the performance of non‐high‐density lipoprotein cholesterol (non‐HDL) in predicting incident diabetes. We aimed to analyze the association between non‐HDL and development of diabetes, and to estimate the cut‐off point of non‐HDL for discriminating incident diabetes in people with normal glucose tolerance.Materials and MethodsOf 3,653 middle‐aged and elderly Chinese with normal glucose tolerance at enrollment, 1,025 men and 1,805 women returned to the 3‐year follow up and were involved in the final analysis. Logistic regression analysis was used to test the association between cholesterol indices and incident diabetes, and receiver operating characteristic analyses were used to identify the optimal cut‐off of each cholesterol variable for incident diabetes.ResultsNon‐HDL was an independent risk factor for diabetes for women, but not for men. In women, a 1‐standard deviation increment in non‐HDL was associated with a 1.43‐fold higher risk of diabetes (95% confidence interval 1.14–1.79; P = 0.002), whereas odds ratios for total cholesterol and low‐density lipoprotein cholesterol were 1.33 (95% confidence interval 1.06–1.67; P = 0.015) and 1.30 (95% confidence interval 1.04–1.64; P = 0.024), respectively. The discriminatory power and the optimal cut‐off value of non‐HDL for incident diabetes increased across body mass index categories. For women with obesity, the threshold of non‐HDL for screening of diabetes was estimated as 3.51 mmol/L.ConclusionsNon‐HDL had better performance than traditional cholesterol indices in predicting diabetes in women, but not in men. A body mass index‐specific threshold value for a non‐HDL‐controlling target is required in the prevention of type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Liu

Qiu

Yuan

et al. 2018

J of Diabetes Invest

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“…The methodology of REACTION study has been described previously 14, 15, 16. Eligible study participants were identified from the local residence registration records and must be age 40 years or older.…”

Section: Methodsmentioning

confidence: 99%

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Lu¹,

et al. 2016

JAHA

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BackgroundChronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.Methods and ResultsThis study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration (CKD‐EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m2), those with decreased eGFR (75–89, 60–74, and <60 mL/min per 1.73 m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m2).ConclusionsEven mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.

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“…This study was one part of the baseline survey from the REACTION study, which was a multicenter, prospective cohort study; its primary objective was to demonstrate whether abnormal glucose metabolism was associated with increased risk of cancer in a Chinese population [5, 6]. The study was approved by the ethics committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine.…”

Section: Methodsmentioning

confidence: 99%

Cutoff Point of HbA1c for Diagnosis of Diabetes Mellitus in Chinese Individuals

Wang

Liu

et al. 2016

PLoS ONE

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BackgroundThe purpose of the present study was to find the optimal threshold of glycated hemoglobin (HbA1c) for diagnosis of diabetes mellitus in Chinese individuals.MethodsA total of 8 391 subjects (including 2 133 men and 6 258 women) aged 40–90 years with gradable retinal photographs were recruited. The relationship between HbA1c and diabetic retinopathy (DR) was examined. Receiver operating characteristic (ROC) curves were used to find the optimal threshold of HbA1c in screening DR and diagnosing diabetes.ResultsHbA1c values in patients with DR were significantly higher than in those with no DR. The ROC curve for HbA1c had an area under the curve of 0.881 (95%CI 0.857–0.905; P = 0.000). HbA1c at a cutoff of 6.5% had a high sensitivity (80.6%) and specificity (86.9%) for detecting DR.ConclusionsHbA1c can be used to diagnose diabetes in a Chinese population, and the optimal HbA1c cutoff point for diagnosis is 6.5%.

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Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)

Abstract: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259 657 adults from the general population across the China.

Cited by 168 publications

References 24 publications

Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Cutoff Point of HbA1c for Diagnosis of Diabetes Mellitus in Chinese Individuals

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