Cohort Profile: The Hokkaido Study on Environment and Children's Health in Japan

Kishi, Reiko; Sasaki, Seiko; Yoshioka, Eiji; Yuasa, Motoyuki; Sata, Fumihiro; Saijo, Yasuaki; Kurahashi, Norie; Tamaki, Junko; Endo, Toshiaki; Sengoku, Kazuo; Nonomura, Katsuya; Minakami, Hisanori

doi:10.1093/ije/dyq071

Cited by 109 publications

(76 citation statements)

References 24 publications

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“…The study participants were native Japanese pregnant women recruited from an ongoing birth cohort: The Hokkaido Study on Environment and Children's Health. The cohort was started in February 2003 and recruitment is ongoing; the details of the study have been described previously elsewhere [15]. All pregnant indigenous Japanese women who were booked to receive antenatal care at any of 37 participating health facilities in Hokkaido were considered eligible for the cohort study.…”

Section: Methodsmentioning

confidence: 99%

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Yamada

Morikawa

Yamada

et al. 2012

Arch Gynecol Obstet

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Objectives: To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR). Study design:A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels. Results:The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3,132 ± 321 g; only one infant had FGR. Conclusion:Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.

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Section: Methodsmentioning

confidence: 99%

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Yamada

Morikawa

Yamada

et al. 2012

Arch Gynecol Obstet

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“…Details of the blood sampling have been reported [25]. All samples were stored at −80°C until analysis.…”

Section: Exposure Measurementmentioning

confidence: 99%

“…[25,26]. Ten registered women were dropped from the study because of miscarriage, stillbirth, withdrawal before delivery, or drop-out at the beginning of the follow-up period.…”

Section: Introductionmentioning

confidence: 99%

Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido study

Kobayashi

Sata

Miyashita

et al. 2017

Reproductive Toxicology

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Highlights We examined the association of prenatal dioxins and polymorphism with birth size. Polymorphisms in 3 genes encoding dioxin-metabolizing enzymes were investigated. Polymorphisms were analyzed in 421 healthy pregnant Japanese women. Dioxin TEQ was associated with reduced birth weight reduction in the GSTM1 null genotype. AbbreviationsAHR, aromatic hydrocarbon receptor; CYP, cytochrome P450; CYP1A1, cytochrome P450 1A1; dbSNP, database single nucleotide polymorphism; GSTM1, glutathione S-transferase mu 1; HRGC/HRMS, high-resolution gas chromatography/high-resolution mass spectrometry; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; PenCB, pentachlorinated biphenyl; PenCDD, pentachlorinated dibenzo-p-dioxin; PenCDF, pentachlorinated dibenzofuran; TEQ, toxic equivalency; TetCDD, tetrachlorinated dibenzo-p-dioxin 3 Abstract Objectives: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin-metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. Methods:We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G>A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu 1 (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. Results:In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345 g (95% confidence interval: -584, -105). Conclusions:We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy.

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“…The study participants were Japanese mother-child pairs drawn from the birth cohort of The Hokkaido Study on Environmental and Children's Health begun in February 2003 [36][37]. The study protocol has been described [36][37].…”

Section: Selection Of Participantsmentioning

confidence: 99%

“…The study protocol has been described [36][37]. In brief, this is a prospective ongoing birth cohort study.…”

Section: Selection Of Participantsmentioning

confidence: 99%

Combined effects of AHR , CYP1A1 , and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study

Kobayashi

Sata

Sasaki

et al. 2016

Reproductive Toxicology

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Cohort Profile: The Hokkaido Study on Environment and Children's Health in Japan

Cited by 109 publications

References 24 publications

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido study

Combined effects of AHR , CYP1A1 , and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study

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